COVID-19, Neuroinflammation and Therapeutics, 2nd Edition

A special issue of Neurology International (ISSN 2035-8377).

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1593

Special Issue Editor


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Guest Editor
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
Interests: anatomy; physiology; pathology; neuromuscular examination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are living in the throes of COVID-19, with new variants and complications emerging regularly. With a continuously growing knowledge base due to information gathered from epidemiological studies, randomized controlled trials (RCTs), observational studies, case reports, and meta-analytical reviews, new light has been shed on different aspects of the direct and indirect disease burden associated with COVID-19. Although primarily a disease of the respiratory system, systematic inflammatory and immune responses have also emerged as a result of COVID-19; this indicates that its manifestations are diverse and affect multiple systems, including the nervous system.

This Special Issue aims to fill knowledge gaps on COVID-19. We are inviting research papers, including reports, observational studies, RCTs, reviews (including narrative reviews), and meta-analytical reviews, that provide novel insights into the clinical features, treatments, therapeutics, and inflammatory biomarkers of COVID-19 (e.g., through laboratory-, neuroimaging-, or neurophysiology-based approaches).

Bringing this new research to the forefront of the scientific community will enhance our understanding of this virus and its effects, especially those related to its neurological complications.

Dr. Yasir Rehman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neurology International is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • SARS-CoV-2 infection
  • neuroinflammation
  • neuroimaging
  • neurophysiology

Published Papers (1 paper)

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Review

14 pages, 969 KiB  
Review
Decoding Post-Viral Fatigue: The Basal Ganglia’s Complex Role in Long-COVID
by Thorsten Rudroff
Neurol. Int. 2024, 16(2), 380-393; https://doi.org/10.3390/neurolint16020028 - 28 Mar 2024
Viewed by 1302
Abstract
Long-COVID afflicts millions with relentless fatigue, disrupting daily life. The objective of this narrative review is to synthesize current evidence on the role of the basal ganglia in long-COVID fatigue, discuss potential mechanisms, and highlight promising therapeutic interventions. A comprehensive literature search was [...] Read more.
Long-COVID afflicts millions with relentless fatigue, disrupting daily life. The objective of this narrative review is to synthesize current evidence on the role of the basal ganglia in long-COVID fatigue, discuss potential mechanisms, and highlight promising therapeutic interventions. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases. Mounting evidence from PET, MRI, and functional connectivity data reveals basal ganglia disturbances in long-COVID exhaustion, including inflammation, metabolic disruption, volume changes, and network alterations focused on striatal dopamine circuitry regulating motivation. Theories suggest inflammation-induced signaling disturbances could impede effort/reward valuation, disrupt cortical–subcortical motivational pathways, or diminish excitatory input to arousal centers, attenuating drive initiation. Recent therapeutic pilots targeting basal ganglia abnormalities show provisional efficacy. However, heterogeneous outcomes, inconsistent metrics, and perceived versus objective fatigue discrepancies temper insights. Despite the growing research, gaps remain in understanding the precise pathways linking basal ganglia dysfunction to fatigue and validating treatment efficacy. Further research is needed to advance understanding of the basal ganglia’s contribution to long-COVID neurological sequelae and offer hope for improving function across the expanding affected population. Full article
(This article belongs to the Special Issue COVID-19, Neuroinflammation and Therapeutics, 2nd Edition)
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