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Viruses, Volume 17, Issue 4

April 2025 - 136 articles

Cover Story: Persistent infection with HPV causes nearly 5% of all cancers worldwide, including cervical and oropharyngeal cancers. Compared to HPV− head and neck squamous-cell carcinomas (HNSCCs), HPV+ HNSCCs exhibit a significantly improved treatment response; however, the established treatment regimens were largely developed for HPV− disease. Effectively de-escalating therapy and optimizing treatment protocols to minimize toxicity for both HPV+ and HPV− tumors has seen varying success, in part due to the heterogeneity of cellular subpopulations. To address this by means of an exploration of the underlying biology, we analyzed published single-cell RNA sequencing data of HPV+ and HPV− HNSCCs to distinguish epithelial tumor cell populations as a function of HPV status. View this paper
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Articles (136)

  • Review
  • Open Access
1 Citations
1,799 Views
12 Pages

Clinical Manifestations of Hemorrhagic Fever with Renal Syndrome, Various Nosologic Forms and Issues of Hantavirus Infections Terminology

  • Evgeniy Tkachenko,
  • Tamara Dzagurova,
  • Guzel Galieva,
  • Victoria Ivanis,
  • Svetlana Kurashova,
  • Petr Tkachenko,
  • Alexandra Balkina,
  • Dmitriy Trankvilevsky and
  • Aydar Ishmukhametov

17 April 2025

Hemorrhagic fever with renal syndrome (HFRS) is the result of acute, zoonotic, natural foci hantavirus infections. It has serious social and medical importance due to its widespread distribution and the disease’s severity. There is a lack of ef...

  • Article
  • Open Access
2,290 Views
19 Pages

Molecular Epidemiology of Human Adenovirus from Acute Gastroenteritis Cases in Brazil After the COVID-19 Pandemic Period, 2021–2023

  • Mateus de Souza Mello,
  • Fábio Correia Malta,
  • Alexandre Madi Fialho,
  • Fernanda Marcicano Burlandy and
  • Tulio Machado Fumian

17 April 2025

Human enteric adenoviruses (HAdV-F40/41) play a crucial role as causative agents of acute gastroenteritis (AGE), particularly affecting children in low-and middle-income countries. This study investigated the prevalence, genetic diversity, and molecu...

  • Article
  • Open Access
1,149 Views
17 Pages

Transmission and Characterization of Creutzfeldt–Jakob Disease and Chronic Wasting Disease in the North American Deer Mouse

  • Jennifer Myskiw,
  • Lise Lamoureux,
  • Kathy Frost,
  • Rebecca Fox,
  • Jessy A. Slota,
  • Gordon Mitchell,
  • Ben A. Bailey-Elkin and
  • Stephanie A. Booth

16 April 2025

Prion transmission into rodents is essential for understanding prion strains. However, it is often limited by a “species barrier” that makes transmission challenging and complicates the study of animal and human prion diseases. Here, we r...

  • Article
  • Open Access
1,285 Views
19 Pages

16 April 2025

Flow virometry (FVM) offers a promising approach for monitoring viruses and virus-like particles (VLPs) in environmental samples. This study compares levels of non-specific VLPs across a wastewater treatment plant (WWTP) with levels of somatic coliph...

  • Article
  • Open Access
1,717 Views
13 Pages

Environmental Suitability of Kazakhstan to Highly Pathogenic Avian Influenza Using Data on Eurasian Outbreaks, 2020–2024

  • Asem Zh. Abenova,
  • Yersyn Y. Mukhanbetkaliyev,
  • Ablaikhan S. Kadyrov,
  • Igor I. Sytnik,
  • Alexander B. Shevtsov,
  • Fedor I. Korennoy,
  • Irene Iglesias Martin,
  • Andres M. Perez and
  • Sarsenbay K. Abdrakhmanov

16 April 2025

Highly pathogenic avian influenza (HPAI) is a highly contagious disease of domestic, synanthropic, and wild birds that has demonstrated a sharp rise globally since 2020. This study intends to examine environmental and demographic factors most signifi...

  • Article
  • Open Access
1,139 Views
20 Pages

Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells

  • Lea Lenhard,
  • Martin Müller,
  • Sandra Diederich,
  • Lisa Loerzer,
  • Virginia Friedrichs,
  • Bernd Köllner,
  • Stefan Finke,
  • Anca Dorhoi and
  • Gang Pei

16 April 2025

Cedar virus (CedV), closely related to the Hendra and Nipah viruses, is a novel Henipavirus that was originally isolated from flying foxes in Australia in 2012. Although its glycoprotein G exhibits relatively low sequence similarity with its counterp...

  • Review
  • Open Access
1 Citations
3,831 Views
26 Pages

16 April 2025

Despite the success of antiretroviral therapy (ART) in suppressing viral replication in the blood, HIV persists in the central nervous system (CNS) and causes chronic neurocognitive impairment, a hallmark of HIV-associated neurocognitive disorders (H...

  • Article
  • Open Access
1,379 Views
17 Pages

Characterization of Nanobody Binding to Distinct Regions of the SARS-CoV-2 Spike Protein by Flow Virometry

  • Mariam Maltseva,
  • Martin A. Rossotti,
  • Jamshid Tanha and
  • Marc-André Langlois

15 April 2025

Nanobodies, or single-domain antibodies (VHHs) from camelid heavy-chain-only antibodies, offer significant advantages in therapeutic and diagnostic applications due to their small size and ability to bind cryptic protein epitopes inaccessible to conv...

  • Article
  • Open Access
1,803 Views
13 Pages

First Report of Paralytic Rabies in a Lowland Tapir (Tapirus terrestris) in Argentina

  • Matías Castillo Giraudo,
  • María Marcela Orozco,
  • Marcelo Juan Zabalza,
  • Leonardo Minatel,
  • Laura Patricia Novaro,
  • Gabriela Alejandra Centurión,
  • Marcos Adolfo Fabeiro,
  • Luciano Coppola,
  • Vanina Daniela Marchione and
  • María Carolina Artuso
  • + 2 authors

15 April 2025

As a significant zoonotic disease, rabies poses substantial economic challenges for the livestock sector, highlighting the need for effective wildlife monitoring as part of a One Health approach. This study documents the first case of paralytic rabie...

  • Article
  • Open Access
1,265 Views
26 Pages

15 April 2025

SARS-CoV-2 has demonstrated a remarkable capacity for immune evasion. While initial studies focused on the Wuhan variant and adaptive immunity, later emerging strains such as Omicron exhibit mutations that may alter their immune-modulatory properties...

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Viruses - ISSN 1999-4915Creative Common CC BY license