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Viruses, Volume 15, Issue 11

November 2023 - 144 articles

Cover Story: Influenza A virus (IAV) causes severe respiratory infections and substantial global morbidity and mortality. Innate immunity, cell death, and inflammation are key in driving severe disease in response to IAV. ZBP1 is an innate immune sensor for IAV infection that triggers NLRP3 inflammasome activation and formation of a PANoptosome complex. Activation of the PANoptosome leads to inflammatory cell death, PANoptosis. However, the role of specific pore-forming molecules downstream of the PANoptosome and potential redundancies between them remain unclear. In this issue, Malireddi et al. show that IAV-induced lytic cell death, PANoptosis, activates MLKL but is not dependent on MLKL. These findings suggest that functional redundancies in pore-forming molecules drive IAV-induced PANoptosis. View this paper
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Articles (144)

  • Article
  • Open Access
6 Citations
3,636 Views
13 Pages

Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin Gene

  • Yuancheng Zhang,
  • Pengfei Cui,
  • Jianzhong Shi,
  • Yuan Chen,
  • Xianying Zeng,
  • Yongping Jiang,
  • Guobin Tian,
  • Chengjun Li,
  • Hualan Chen and
  • Huihui Kong
  • + 1 author

13 November 2023

The H5 subtype highly pathogenic avian influenza viruses bearing the clade 2.3.4.4 HA gene have been pervasive among domestic poultry and wild birds worldwide since 2014, presenting substantial risks to human and animal health. Continued circulation...

  • Brief Report
  • Open Access
2,054 Views
10 Pages

Evolutionary Insight into the Association between New Jersey Polyomavirus and Humans

  • Aref-Abdolllah Aghebatrafat,
  • Chris Lauber,
  • Kevin Merkel,
  • Barbara Fruth,
  • Kevin Langergraber,
  • Martha M. Robbins,
  • Roman M. Wittig,
  • Fabian H. Leendertz and
  • Sébastien Calvignac-Spencer

13 November 2023

Advances in viral discovery techniques have led to the identification of numerous novel viruses in human samples. However, the low prevalence of certain viruses in humans raises doubts about their association with our species. To ascertain the authen...

  • Article
  • Open Access
14 Citations
3,041 Views
14 Pages

11 November 2023

The porcine reproductive and respiratory syndrome virus (PRRSV) has caused significant economic losses to the swine industry. The U.S., China, and Peru have reported NADC30-like or NADC34-like PRRSV-infected piglets, which have been identified as the...

  • Article
  • Open Access
46 Citations
6,818 Views
13 Pages

A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups

  • Edward Spinard,
  • Mark Dinhobl,
  • Nicolas Tesler,
  • Hillary Birtley,
  • Anthony V. Signore,
  • Aruna Ambagala,
  • Charles Masembe,
  • Manuel V. Borca and
  • Douglas P. Gladue

11 November 2023

The African swine fever virus (ASFV) is currently causing a world-wide pandemic of a highly lethal disease in domestic swine and wild boar. Currently, recombinant ASF live-attenuated vaccines based on a genotype II virus strain are commercially avail...

  • Brief Report
  • Open Access
3 Citations
1,996 Views
7 Pages

Does the Presence or a High Titer of Yellow Fever Virus Antibodies Interfere with Pregnancy Outcomes in Women with Zika Virus Infection?

  • Isa Cristina Ribeiro Piauilino,
  • Raillon Keven dos Santos Souza,
  • Maurício Teixeira Lima,
  • Yanka Karolinna Batista Rodrigues,
  • Luís Felipe Alho da Silva,
  • Ayrton Sena Gouveia,
  • Alexandre Vilhena da Silva Neto,
  • Bárbara Aparecida Chaves,
  • Maria das Graças Costa Alecrim and
  • Camila Helena Aguiar Bôtto de Menezes
  • + 3 authors

11 November 2023

Zika virus (ZIKV) and yellow fever virus (YFV) originated in Africa and expanded to the Americas, where both are co-circulated. It is hypothesized that in areas of high circulation and vaccination coverage against YFV, children of pregnant women have...

  • Article
  • Open Access
8 Citations
2,724 Views
14 Pages

Web Service for HIV Drug Resistance Prediction Based on Analysis of Amino Acid Substitutions in Main Drug Targets

  • Anastasiia Iu. Paremskaia,
  • Anastassia V. Rudik,
  • Dmitry A. Filimonov,
  • Alexey A. Lagunin,
  • Vladimir V. Poroikov and
  • Olga A. Tarasova

11 November 2023

Predicting viral drug resistance is a significant medical concern. The importance of this problem stimulates the continuous development of experimental and new computational approaches. The use of computational approaches allows researchers to increa...

  • Article
  • Open Access
1 Citations
2,242 Views
12 Pages

Neutralizing Antibody Response to Genotypically Diverse Measles Viruses in Clinically Suspected Measles Cases

  • Sunil R. Vaidya,
  • Neelakshi S. Kumbhar,
  • Gargi K. Andhare,
  • Nilesh Pawar,
  • Atul M. Walimbe,
  • Meenal Kinikar,
  • Sunitha M. Kasibhatla and
  • Urmila Kulkarni-Kale

10 November 2023

The neutralizing antibody (Nt-Ab) response to vaccine and wild-type measles viruses (MeV) was studied in suspected measles cases reported during the years 2012–2016. The neutralization activity against MeV A, D4 and D8 genotypes was studied on...

  • Article
  • Open Access
3 Citations
2,290 Views
12 Pages

10 November 2023

South Africa has a dual high burden of HIV and drug-resistant TB (DR-TB). We sought to understand the association of HIV and antiretroviral therapy status with TB treatment outcomes. This was a retrospective chart review of 246 patients who began tre...

  • Systematic Review
  • Open Access
11 Citations
3,045 Views
13 Pages

Lamivudine and Entecavir for Acute Hepatitis B: A Systematic Review and Meta-Analysis

  • Cesar Henriquez-Camacho,
  • Ana Isabel Hijas-Gomez,
  • Carlos Risco Risco,
  • Maria Angeles Ruiz Lapuente,
  • Rosa Escudero-Sanchez and
  • Victor Moreno Cuerda

10 November 2023

Background. Acute hepatitis B infection is associated with severe liver disease and chronic sequelae in some cases. The purpose of this review was to determine the efficacy of nucleoside analogues (NA) (lamivudine versus entecavir) compared to placeb...

  • Article
  • Open Access
4 Citations
4,000 Views
23 Pages

Development, Evaluation, and Clinical Application of PRRSV-2 Vaccine-like Real-Time RT-PCR Assays

  • Gaurav Rawal,
  • Karen M. Krueger,
  • Wannarat Yim-im,
  • Ganwu Li,
  • Phillip C. Gauger,
  • Marcelo N. Almeida,
  • Ethan K. Aljets and
  • Jianqiang Zhang

10 November 2023

In this study, we developed and validated (1) singleplex real-time RT-PCR assays for specific detection of five PRRSV-2 MLV vaccine viruses (Ingelvac MLV, Ingelvac ATP, Fostera, Prime Pac, and Prevacent) and (2) a four-plex real-time RT-PCR assay (In...

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Viruses - ISSN 1999-4915