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Viruses, Volume 15, Issue 11

November 2023 - 144 articles

Cover Story: Influenza A virus (IAV) causes severe respiratory infections and substantial global morbidity and mortality. Innate immunity, cell death, and inflammation are key in driving severe disease in response to IAV. ZBP1 is an innate immune sensor for IAV infection that triggers NLRP3 inflammasome activation and formation of a PANoptosome complex. Activation of the PANoptosome leads to inflammatory cell death, PANoptosis. However, the role of specific pore-forming molecules downstream of the PANoptosome and potential redundancies between them remain unclear. In this issue, Malireddi et al. show that IAV-induced lytic cell death, PANoptosis, activates MLKL but is not dependent on MLKL. These findings suggest that functional redundancies in pore-forming molecules drive IAV-induced PANoptosis. View this paper
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Articles (144)

  • Article
  • Open Access
2,372 Views
16 Pages

A Novel Subcluster of Closely Related Bacillus Phages with Distinct Tail Fiber/Lysin Gene Combinations

  • Rachel E. Loney,
  • Véronique A. Delesalle,
  • Brianne E. Chaudry,
  • Megan Czerpak,
  • Alexandra A. Guffey,
  • Leo Goubet-McCall,
  • Michael McCarty,
  • Madison S. Strine,
  • Natalie T. Tanke and
  • Albert C. Vill
  • + 1 author

17 November 2023

Bacteriophages (phages) are the most numerous entities on Earth, but we have only scratched the surface of describing phage diversity. We isolated seven Bacillus subtilis phages from desert soil in the southwest United States and then sequenced and c...

  • Article
  • Open Access
4 Citations
2,764 Views
11 Pages

Presence and Persistence of Andes Virus RNA in Human Semen

  • Roland Züst,
  • Rahel Ackermann-Gäumann,
  • Nicole Liechti,
  • Denise Siegrist,
  • Sarah Ryter,
  • Jasmine Portmann,
  • Nicole Lenz,
  • Christian Beuret,
  • Roger Koller and
  • Cornelia Staehelin
  • + 4 authors

17 November 2023

When infecting humans, Andes orthohantavirus (ANDV) may cause a severe disease called hantavirus cardiopulmonary syndrome (HCPS). Following non-specific symptoms, the infection may progress to a syndrome of hemorrhagic fever combined with hyper-acute...

  • Article
  • Open Access
2 Citations
2,833 Views
12 Pages

The Prevalence, Seroprevalence, and Risk Factors of Tick-Borne Encephalitis Virus in Dogs in Lithuania, a Highly Endemic State

  • Evelina Simkute,
  • Arnoldas Pautienius,
  • Juozas Grigas,
  • Paulina Urbute and
  • Arunas Stankevicius

17 November 2023

The rising awareness and increasing number of case reports of tick-borne encephalitis (TBE) in dogs indicate that the virus might be an important tick-borne pathogen in dogs, especially in endemic areas. Therefore, the aim of the present study was to...

  • Article
  • Open Access
3 Citations
2,767 Views
13 Pages

Prophylactic Treatment with Baloxavir Protects Mice from Lethal Infection with Influenza A and B Viruses

  • Keita Fukao,
  • Takeshi Noshi,
  • Shinya Shano,
  • Kaoru Baba,
  • Kenji Sato,
  • Masashi Sakuramoto,
  • Naohisa Kitade,
  • Hideki Tanioka,
  • Shinji Kusakabe and
  • Takao Shishido

16 November 2023

Influenza remains a worldwide health concern. Antiviral drugs are considered as one of the useful options for its prevention as a complementary measure to vaccination. Baloxavir acid selectively inhibits the cap-dependent endonuclease of influenza vi...

  • Article
  • Open Access
2 Citations
1,822 Views
16 Pages

Phenotypic Characterization of Recombinant Marek’s Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence

  • Taejoong Kim,
  • Cari J. Hearn,
  • Jody Mays,
  • Deborah Velez-Irizarry,
  • Sanjay M. Reddy,
  • Stephen J. Spatz,
  • Hans H. Cheng and
  • John R. Dunn

16 November 2023

Marek’s disease (MD) is a highly infectious lymphoproliferative disease in chickens with a significant economic impact. Mardivirus gallidalpha 2, also known as Marek’s disease virus (MDV), is the causative pathogen and has been categorize...

  • Review
  • Open Access
14 Citations
3,884 Views
17 Pages

Tumor Tropism of DNA Viruses for Oncolytic Virotherapy

  • Junior A. Enow,
  • Hummad I. Sheikh and
  • Masmudur M. Rahman

16 November 2023

Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA ge...

  • Article
  • Open Access
22 Citations
4,726 Views
12 Pages

An Outbreak of Parvovirus B19 in Israel

  • Tal Patalon,
  • Yaki Saciuk,
  • Daniel Trotzky,
  • Gal Pachys,
  • Amir Ben-Tov,
  • Yaakov Segal and
  • Sivan Gazit

16 November 2023

Human parvovirus B19 (B19V) has a wide clinical spectrum, ranging from an asymptomatic infection to a life threatening one. During pregnancy, it can lead to fetal loss and hydrops fetalis. This retrospective study examined the incidence rates of B19V...

  • Article
  • Open Access
8 Citations
2,320 Views
11 Pages

Association between Pulmonary Aspergillosis and Cytomegalovirus Reactivation in Critically Ill COVID-19 Patients: A Prospective Observational Cohort Study

  • Valeria Caciagli,
  • Irene Coloretti,
  • Marta Talamonti,
  • Carlotta Farinelli,
  • Ilenia Gatto,
  • Emanuela Biagioni,
  • Mario Sarti,
  • Erica Franceschini,
  • Marianna Meschiari and
  • Cristina Mussini
  • + 5 authors

15 November 2023

COVID-19-associated invasive pulmonary aspergillosis (CAPA) is common and is associated with poor outcomes in critically ill patients. This prospective observational study aimed to explore the association between CAPA development and the incidence an...

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Viruses - ISSN 1999-4915