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Viruses, Volume 13, Issue 9

September 2021 - 214 articles

Cover Story: Cell-to-cell spread is an important mechanism of herpesvirus for their dissemination and to evade the host immune response. The molecular tweezer, CLR01, exhibits broad-spectrum antiviral activity against enveloped viruses, which is based on its affinity for viral envelopes and their rapid disruption. CLR01 not only inhibits infection by cell-free viruses but also prevents cell-to-cell spread of herpesviruses, providing valuable mechanistic insights. Furthermore, it marks the viral envelope as an interesting and promising target for future drug development. View this paper.
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Articles (214)

  • Review
  • Open Access
16 Citations
6,449 Views
20 Pages

21 September 2021

Viruses are obligate intracellular parasites that are dependent on host factors for their replication. One such host protein, p97 or the valosin-containing protein (VCP), is a highly conserved AAA ATPase that facilitates replication of diverse RNA- a...

  • Review
  • Open Access
19 Citations
5,304 Views
23 Pages

Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies

  • Huyen Tran Ho,
  • Stefan Peischard,
  • Nathalie Strutz-Seebohm,
  • Karin Klingel and
  • Guiscard Seebohm

21 September 2021

Evidence is emerging that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect various organs of the body, including cardiomyocytes and cardiac endothelial cells in the heart. This review focuses on the effects of SARS-CoV-2 in the...

  • Review
  • Open Access
100 Citations
14,966 Views
15 Pages

Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics

  • Esteban Domingo,
  • Carlos García-Crespo,
  • Rebeca Lobo-Vega and
  • Celia Perales

21 September 2021

The error rate displayed during template copying to produce viral RNA progeny is a biologically relevant parameter of the replication complexes of viruses. It has consequences for virus–host interactions, and it represents the first step in the diver...

  • Review
  • Open Access
14 Citations
5,925 Views
21 Pages

21 September 2021

The neurovascular units (NVU) are the minimal functional units of the blood–brain barrier (BBB), composed of endothelial cells, pericytes, astrocytes, microglia, neurons, and the basement membrane. The BBB serves as an important interface for immune...

  • Review
  • Open Access
26 Citations
7,194 Views
18 Pages

Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults

  • Giovanni Battista Biserni,
  • Sara Scarpini,
  • Arianna Dondi,
  • Carlotta Biagi,
  • Luca Pierantoni,
  • Riccardo Masetti,
  • Sugitha Sureshkumar,
  • Alessandro Rocca and
  • Marcello Lanari

21 September 2021

Human Adenoviruses (HAdV) are known to be potentially associated with strong inflammatory responses and morbidity in pediatric patients. Although most of the primary infections are self-limiting, the severity of clinical presentation, the elevation o...

  • Article
  • Open Access
16 Citations
5,839 Views
16 Pages

COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes

  • Estibalitz Laresgoiti-Servitje,
  • Jorge Arturo Cardona-Pérez,
  • Rosa Gabriela Hernández-Cruz,
  • Addy Cecilia Helguera-Repetto,
  • María Yolotzin Valdespino-Vázquez,
  • Elsa Romelia Moreno-Verduzco,
  • Isabel Villegas-Mota,
  • Sandra Acevedo-Gallegos,
  • Mario Rodríguez-Bosch and
  • Moisés León-Juárez
  • + 14 authors

21 September 2021

(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control...

  • Article
  • Open Access
14 Citations
3,929 Views
13 Pages

21 September 2021

Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals with serious economic consequences. FMD is endemic in Southeast Asia (SEA) and East Asia (EA) with the circulation of multiple serotypes, posing a threat to Australi...

  • Review
  • Open Access
16 Citations
5,389 Views
27 Pages

21 September 2021

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has expanded into a global pandemic, with more than 220 million affected persons and almost 4.6 million deaths by 8 September 2021. In particular, Europe and the Americas have bee...

  • Review
  • Open Access
75 Citations
12,266 Views
18 Pages

Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

  • Zijing Guo,
  • Zhidong Zhang,
  • Meera Prajapati and
  • Yanmin Li

20 September 2021

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Det...

  • Review
  • Open Access
43 Citations
6,718 Views
20 Pages

Vertical Transmission of SARS-CoV-2: A Systematic Review of Systematic Reviews

  • Salihu S. Musa,
  • Umar M. Bello,
  • Shi Zhao,
  • Zainab U. Abdullahi,
  • Muhammad A. Lawan and
  • Daihai He

20 September 2021

The COVID-19 pandemic has hugely impacted global public health and economy. The COVID-19 has also shown potential impacts on maternal perinatal and neonatal outcomes. This systematic review aimed to summarize the evidence from existing systematic rev...

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Viruses - ISSN 1999-4915Creative Common CC BY license