Special Issue "Chaperones and Viral-Host Interactions"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Jaquelin Dudley
E-Mail Website
Guest Editor
The University of Texas at Austin; Department of Molecular Biosciences, Center for Infectious Disease, and Institute for Cellular and Molecular Biology, Austin, TX 78712, USA
Interests: pathogenesis and molecular biology of retroviruses
Special Issues and Collections in MDPI journals

Special Issue Information

Viruses are obligate intracellular parasites that are dependent on host factors for their propagation and survival. Interactions between viral and host proteins have continued to co-evolve to shape and maximize virus transmission. Study of virus-host interactions is important for determining the final outcome of viral infections. Chaperones are critical host proteins that promote multiple aspects of viral replication.  For example, one host protein that plays multiple roles in different stages of the viral life cycle is valosin-containing protein (VCP), also known as p97 in mammals or Cdc48 in yeast. This highly conserved AAA ATPase participates in virtually every stage of virus replication from entry, trafficking, nucleic acid replication, and maturation.  Furthermore, viral proteins, such as SV40 T antigen, have their own chaperone activities.  Both RNA-containing and DNA-containing viruses use chaperone functions for multiple aspects of their life cycles. Better understanding of the molecular details of viral and host chaperones will provide important information about normal cellular processes and how viruses manipulate them.  Continued studies are predicted to have clinical importance for the design of antiviral and vaccine strategies.

Prof. Dr. Jaquelin Dudley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chaperones
  • p97
  • valosin-containing protein
  • protein folding
  • ATPase
  • ERAD
  • viral replication
  • trafficking
  • viral entry
  • transcription
  • subcellular localization
  • proteostasis
  • assembly
  • viral-host interactions

Published Papers (1 paper)

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Review

Review
How DNA and RNA Viruses Exploit Host Chaperones to Promote Infection
Viruses 2021, 13(6), 958; https://doi.org/10.3390/v13060958 - 21 May 2021
Viewed by 798
Abstract
To initiate infection, a virus enters a host cell typically via receptor-dependent endocytosis. It then penetrates a subcellular membrane, reaching a destination that supports transcription, translation, and replication of the viral genome. These steps lead to assembly and morphogenesis of the new viral [...] Read more.
To initiate infection, a virus enters a host cell typically via receptor-dependent endocytosis. It then penetrates a subcellular membrane, reaching a destination that supports transcription, translation, and replication of the viral genome. These steps lead to assembly and morphogenesis of the new viral progeny. The mature virus finally exits the host cell to begin the next infection cycle. Strikingly, viruses hijack host molecular chaperones to accomplish these distinct entry steps. Here we highlight how DNA viruses, including polyomavirus and the human papillomavirus, exploit soluble and membrane-associated chaperones to enter a cell, penetrating and escaping an intracellular membrane en route for infection. We also describe the mechanism by which RNA viruses—including flavivirus and coronavirus—co-opt cytosolic and organelle-selective chaperones to promote viral endocytosis, protein biosynthesis, replication, and assembly. These examples underscore the importance of host chaperones during virus infection, potentially revealing novel antiviral strategies to combat virus-induced diseases. Full article
(This article belongs to the Special Issue Chaperones and Viral-Host Interactions)
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