Special Issue "RNA Viruses: Structure, Adaptation, and Evolution"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editors

Dr. Hironori Sato

Guest Editor
Center for Pathogen Genomics, National Institute of Infectious Diseases, Tokyo, Japan
Interests: Mutational and structural basis of survival strategies of RNA viruses or emerging/re-emerging viruses; structural basis of order of assembly and disassembly of viral molecules in cells; protein structure, dynamics, allosteric regulation, structural/functional constraints, and evolvability
Dr. Akio Adachi
Guest Editor
Kansai Medical University, Osaka, Japan
Interests: Human/animal RNA viruses; HIV/SIV; viral pathogenesis; viral mutation/adaptation/evolution; molecular genetics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In an increasingly globalized world, emerging/re-emerging infectious diseases caused by RNA viruses are becoming a very important issue in public health. RNA viruses are generally highly mutable and adaptable. These characteristics allow them to rapidly change structure and biological phenotype via natural selection under a changing environment, sometimes leading to persistent infection in a host or to outbreaks of emerging/re-emerging infectious diseases in populations. Owing to rapid advances in genomics, we now know much more than before on how RNA viruses maintain and alter genetic information for survival in nature. However, we still do not know much about how these genetic changes impact viral phenotypes, and thus, we are insufficiently ready to understand emerging/re-emerging infectious diseases.

In this Special Issue, we welcome a wide range of articles, including original research, short communications, and reviews, that focus on the structure, adaptation, and evolution of RNA viruses. Studies with animal/plant models or computational approaches are also welcome. Topics of interest include observations and/or underlying mechanisms of (i) viral genetic changes in nature, (ii) phenotypical changes with biological/epidemiological/clinical relevance (e.g., drug resistance, immune escape, changes in cell/tissue-tropism or host range, transmissibility, and pathogenesis), (iii) persistent infection in a host or populations, (iv) structural and functional constraints of viral molecules against changes, (v) the allosteric network of viral proteins, (vi) fitness trade-offs and adaptation under antivirals/vaccines/immune pressures, (vii) the co-evolution of viral genes or proteins, and (viii) emerging/re-emerging zoonoses and infectious diseases.

We look forward to receiving your submissions for this Special Issue.

Dr. Hironori Sato
Dr. Akio Adachi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • RNA viruses
  • structure
  • function
  • mutation
  • adaptation
  • evolution
  • animal model
  • computational science
  • persistent infection
  • emerging/re-emerging infectious diseases

Published Papers

This special issue is now open for submission.
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