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Review

The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients

1
Department of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland
2
Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
These authors contribute equally to this work and share the first authorship.
Academic Editors: Elizabeth M. Anderson and Sigrid Gouma
Viruses 2021, 13(9), 1879; https://doi.org/10.3390/v13091879
Received: 31 July 2021 / Revised: 13 September 2021 / Accepted: 17 September 2021 / Published: 20 September 2021
(This article belongs to the Special Issue Pre-existing Immunity Effects on Viral Infections and Vaccinations)
Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. It was postulated that the hyperinflammatory state due to cytokine release syndrome during severe COVID-19 could be alleviated by immunosuppressive therapy in SOT patients. On the other hand, it was previously established that T cell-mediated immunity, which is significantly weakened in SOT recipients, is the main component of antiviral immune responses. In this paper, we present the current state of science on COVID-19 immunology in relation to solid organ transplantation with prospective therapeutic and vaccination strategies in this population. View Full-Text
Keywords: solid organ transplant recipients; COVID-19; cellular immunity; humoral immunity; vaccination solid organ transplant recipients; COVID-19; cellular immunity; humoral immunity; vaccination
MDPI and ACS Style

Dęborska-Materkowska, D.; Kamińska, D. The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients. Viruses 2021, 13, 1879. https://doi.org/10.3390/v13091879

AMA Style

Dęborska-Materkowska D, Kamińska D. The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients. Viruses. 2021; 13(9):1879. https://doi.org/10.3390/v13091879

Chicago/Turabian Style

Dęborska-Materkowska, Dominika, and Dorota Kamińska. 2021. "The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients" Viruses 13, no. 9: 1879. https://doi.org/10.3390/v13091879

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