Table of Contents
Viruses, Volume 12, Issue 6 (June 2020) – 110 articles
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Cover Story (view full-size image) Human cytomegalovirus (HCMV) encodes the G protein-coupled receptor (GPCR) homologs US28 and UL33. [...] Read more. Human cytomegalovirus (HCMV) encodes the G protein-coupled receptor (GPCR) homologs US28 and UL33. In this issue of Viruses, van Senten and colleagues describe the role of these receptors in virus dissemination of the clinical HCMV strain Merlin. They observed that both US28 and UL33 contribute to cell-associated virus spread. Moreover, UL33 facilitates cell-free HCMV Merlin transmission. The microscopy image shows the expression of UL33 (green) and US28 (red) in HCMV-infected fibroblasts (cell nuclei in blue). The graph shows the effect of US28 and UL33 deletion on HCMV dissemination in a multistep viral growth experiment. View this paper