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Viruses, Volume 12, Issue 1

January 2020 - 125 articles

Cover Story: Presenting antigen as a repetitive array in a multivalent fashion on virus-like particles (VLP) or nanoparticles (NP) drives a stronger immune response than free antigen. This effect mainly derives from stronger B cell activation through antigen-driven cross-linking of B cell receptors (BCRs) and potentially modified antigen trafficking. In this issue of Viruses, Perotti and Perez review several VLP and NP technologies that could enhance efficacy against the human cytomegalovirus (HCMV).View this paper.
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Articles (125)

  • Communication
  • Open Access
17 Citations
5,472 Views
9 Pages

5,6-Dichloro-2-Phenyl-Benzotriazoles: New Potent Inhibitors of Orthohantavirus

  • Giuseppina Sanna,
  • Sandra Piras,
  • Silvia Madeddu,
  • Bernardetta Busonera,
  • Boris Klempa,
  • Paola Corona,
  • Roberta Ibba,
  • Gabriele Murineddu,
  • Antonio Carta and
  • Roberta Loddo

20 January 2020

Orthohantaviruses, previously known as hantaviruses (family Hantaviridae, order Bunyavirales), are emerging zoonoses hosted by different rodent and insectivore species. Orthohantaviruses are transmitted by aerosolized excreta (urine, saliva and feces...

  • Brief Report
  • Open Access
14 Citations
7,449 Views
12 Pages

Multi-Approach Investigation Regarding the West Nile Virus Situation in Hungary, 2018

  • Brigitta Zana,
  • Károly Erdélyi,
  • Anna Nagy,
  • Eszter Mezei,
  • Orsolya Nagy,
  • Mária Takács,
  • Tamás Bakonyi,
  • Petra Forgách,
  • Orsolya Korbacska-Kutasi and
  • Orsolya Fehér
  • + 12 authors

20 January 2020

The West Nile virus is endemic in multiple European countries and responsible for several epidemics throughout the European region. Its evolution into local or even widespread epidemics is driven by multiple factors from genetic diversification of th...

  • Article
  • Open Access
27 Citations
14,502 Views
9 Pages

Identification of a Novel Papillomavirus Associated with Squamous Cell Carcinoma in a Domestic Cat

  • Maura Carrai,
  • Kate Van Brussel,
  • Mang Shi,
  • Ci-Xiu Li,
  • Wei-Shan Chang,
  • John S. Munday,
  • Katja Voss,
  • Alicia McLuckie,
  • David Taylor and
  • Andrew Laws
  • + 3 authors

20 January 2020

Papillomaviruses infect the skin and mucosal surfaces of diverse animal hosts with consequences ranging from asymptomatic colonization to highly malignant epithelial cancers. Increasing evidence suggests a role for papillomaviruses in the most common...

  • Article
  • Open Access
32 Citations
8,488 Views
12 Pages

Characterization of the Immune Response of MERS-CoV Vaccine Candidates Derived from Two Different Vectors in Mice

  • Entao Li,
  • Feihu Yan,
  • Pei Huang,
  • Hang Chi,
  • Shengnan Xu,
  • Guohua Li,
  • Chuanyu Liu,
  • Na Feng,
  • Hualei Wang and
  • Yongkun Zhao
  • + 2 authors

20 January 2020

Middle East respiratory syndrome (MERS) is an acute, high-mortality-rate, severe infectious disease caused by an emerging MERS coronavirus (MERS-CoV) that causes severe respiratory diseases. The continuous spread and great pandemic potential of MERS-...

  • Case Report
  • Open Access
16 Citations
5,393 Views
11 Pages

Using the LN34 Pan-Lyssavirus Real-Time RT-PCR Assay for Rabies Diagnosis and Rapid Genetic Typing from Formalin-Fixed Human Brain Tissue

  • Rene Edgar Condori,
  • Michael Niezgoda,
  • Griselda Lopez,
  • Carmen Acosta Matos,
  • Elinna Diaz Mateo,
  • Crystal Gigante,
  • Claire Hartloge,
  • Altagracia Pereira Filpo,
  • Joseph Haim and
  • Panayampalli Subbian Satheshkumar
  • + 4 authors

18 January 2020

Human rabies post mortem diagnostic samples are often preserved in formalin. While immunohistochemistry (IHC) has been routinely used for rabies antigen detection in formalin-fixed tissue, the formalin fixation process causes nucleic acid fragmentati...

  • Review
  • Open Access
14 Citations
5,009 Views
19 Pages

Microtubules in Polyomavirus Infection

  • Lenka Horníková,
  • Kateřina Bruštíková and
  • Jitka Forstová

18 January 2020

Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection. In this review, we summarize the role o...

  • Article
  • Open Access
9 Citations
3,868 Views
12 Pages

Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns

  • Sten Calvelage,
  • Marcin Smreczak,
  • Anna Orłowska,
  • Conrad Martin Freuling,
  • Thomas Müller,
  • Christine Fehlner-Gardiner,
  • Susan Nadin-Davis,
  • Dirk Höper and
  • Paweł Trębas

17 January 2020

Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induce...

  • Article
  • Open Access
13 Citations
5,433 Views
13 Pages

Real Time Analysis of Bovine Viral Diarrhea Virus (BVDV) Infection and Its Dependence on Bovine CD46

  • Christiane Riedel,
  • Hann-Wei Chen,
  • Ursula Reichart,
  • Benjamin Lamp,
  • Vibor Laketa and
  • Till Rümenapf

17 January 2020

Virus attachment and entry is a complex interplay of viral and cellular interaction partners. Employing bovine viral diarrhea virus (BVDV) encoding an mCherry-E2 fusion protein (BVDVE2-mCherry), being the first genetically labelled member of the fami...

  • Review
  • Open Access
42 Citations
16,794 Views
20 Pages

Microtubules in Influenza Virus Entry and Egress

  • Caitlin Simpson and
  • Yohei Yamauchi

17 January 2020

Influenza viruses are respiratory pathogens that represent a significant threat to public health, despite the large-scale implementation of vaccination programs. It is necessary to understand the detailed and complex interactions between influenza vi...

  • Article
  • Open Access
14 Citations
4,446 Views
18 Pages

Integrated Analysis of Differentially Expressed miRNAs and mRNAs in Goat Skin Fibroblast Cells in Response to Orf Virus Infection Reveals That cfa-let-7a Regulates Thrombospondin 1 Expression

  • Feng Pang,
  • Xinying Wang,
  • Zhen Chen,
  • Zhenxing Zhang,
  • Mengmeng Zhang,
  • Chengqiang Wang,
  • Xiaohong Yang,
  • Qi An,
  • Li Du and
  • Fengyang Wang

17 January 2020

Orf is a zoonotic disease that has caused huge economic losses globally. Systematical analysis of dysregulated cellular micro RNAs (miRNAs) in response to Orf virus (ORFV) infection has not been reported. In the current study, miRNA sequencing and RN...

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Viruses - ISSN 1999-4915