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Viruses, Volume 12, Issue 1 (January 2020) – 125 articles
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Cover Story (view full-size image) Presenting antigen as a repetitive array in a multivalent fashion on virus-like particles (VLP) or [...] Read more. Presenting antigen as a repetitive array in a multivalent fashion on virus-like particles (VLP) or nanoparticles (NP) drives a stronger immune response than free antigen. This effect mainly derives from stronger B cell activation through antigen-driven cross-linking of B cell receptors (BCRs) and potentially modified antigen trafficking. In this issue of Viruses, Perotti and Perez review several VLP and NP technologies that could enhance efficacy against the human cytomegalovirus (HCMV).View this paper.