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Viruses 2019, 11(2), 150;

Genetic Determinants of the Re-Emergence of Arboviral Diseases

Department of Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA
Department of Immunology, School of Medicine, The University of Connecticut Health Center, Farmington, CT 06030, USA
Author to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 3 February 2019 / Accepted: 6 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Chikungunya Virus and (Re-) Emerging Alphaviruses)
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Mosquito-borne diseases constitute a large portion of infectious diseases, causing more than 700,000 deaths annually. Mosquito-transmitted viruses, such as yellow fever, dengue, West Nile, chikungunya, and Zika viruses, have re-emerged recently and remain a public health threat worldwide. Global climate change, rapid urbanization, burgeoning international travel, expansion of mosquito populations, vector competence, and host and viral genetics may all together contribute to the re-emergence of arboviruses. In this brief review, we summarize the host and viral genetic determinants that may enhance infectivity in the host, viral fitness in mosquitoes and viral transmission by mosquitoes. View Full-Text
Keywords: Arbovirus; host; genetic; evolution; vector; re-emergence Arbovirus; host; genetic; evolution; vector; re-emergence

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Ketkar, H.; Herman, D.; Wang, P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses 2019, 11, 150.

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