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Int. J. Environ. Res. Public Health, Volume 16, Issue 17 (September-1 2019)
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Cover Story (view full-size image) Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatopathy in Western [...] Read more. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatopathy in Western countries. New evidence suggests that NAFLD has a multifaceted relationship with diabetes and metabolic syndrome and is associated with increased risk of cardiovascular events, regardless of traditional risk factors. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolism are some of the mechanisms by which NAFLD increases the risk of cardiovascular disease. Given the pandemic-level rise of NAFLD—in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome—we provided a critical review of the literature relevant to the clinical conundrum of NAFLD with cardiovascular morbidity and mortality. View this paper