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Marine Drugs, Volume 3, Issue 2

June 2005 - 5 articles

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Articles (5)

  • Article
  • Open Access
30 Citations
9,805 Views
10 Pages

Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line

  • Taiko Oda,
  • Michio Namikoshi,
  • Kyoko Akano,
  • Hisayoshi Kobayashi,
  • Yoshio Honma and
  • Tadashi Kasahara

2 June 2005

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60...

  • Article
  • Open Access
35 Citations
8,353 Views
7 Pages

1 June 2005

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-4...

  • Article
  • Open Access
28 Citations
14,085 Views
28 Pages

1 June 2005

Reverse chemical proteomics combines affinity chromatography with phage display and promises to be a powerful new platform technology for the isolation of natural product receptors, facilitating the drug discovery process by rapidly linking biologica...

  • Article
  • Open Access
18 Citations
8,882 Views
7 Pages

16 April 2005

The extract of the sea hare, Aplysia kurodai, showed cytotoxicity against HeLa cells and antibacterial activity against Staphylococcus aureus. Bioassay-guided purification afforded four active compounds, which were identified to be laurinterol, lauri...

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Mar. Drugs - ISSN 1660-3397