Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale
Abstract
:Introduction
Results and Discussion
Conclusion
Experimental
General
Extraction and Isolation
Preparation of Proteasome-enriched Fraction
Assay for Proteasome Activity
position | δH |
---|---|
2 | 2.60 m, 2.70 m |
3 | 4.22 m |
4 | 2.50 m, 2.50 m |
5 | 7.00 dt (16.8, 6.6) |
6 | 6.25 d (16.8) |
8 | 3.50 m |
8-Me | 0.93 d (6.6) |
9 | 4.34 d (9.0) |
9-OMe | 3.19 s |
11 | 7.77 s |
14 | 8.50 s |
18-OMe | 4.05 s |
19 | 5.98 d (16.2) |
20 | 6.84 ddd (16.2, 7.5, 6.0) |
21 | 2.50 m, 2.75 m |
22 | 3.58 m |
22-OMe | 3.45 s |
23 | 1.92 m |
23-Me | 0.94 d (6.6) |
24 | 5.22 m |
25 | 1.55m, 1.60 m |
26 | 2.99 m |
26-OMe | 3.30 s |
27 | 1.74 m |
27-Me | 0.84 d (6.6) |
28 | 1.25 m, 1.74 m |
29 | 2.47 m, 2.47 m |
31 | 2.77 m |
31-Me | 1.07 d (6.6) |
32 | 5.16 dd (9.7, 2.9) |
32-OAc | 2.01 s |
33 | 2.50 m |
33-Me | 1.05 d (6.6) |
34 | 4.97 dd (14.1, 9.4) [5.00 dd (14.1, 9.4)]a |
35 | 6.50 d (14.1) [7.16 d (14.1)] a |
35-NMe | 3.03 s [3.08 s] a |
35-NCHO | 8.30 s [8.08 s] a |
Acknowledgments
- Samples Availability: Not available.
References and Notes
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- Since secomycalolide A (1) decomposed during storage, 13C NMR spectra could not be measured.
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Tsukamoto, S.; Koimaru, K.; Ohta, T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Mar. Drugs 2005, 3, 29-35. https://doi.org/10.3390/md302029
Tsukamoto S, Koimaru K, Ohta T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Marine Drugs. 2005; 3(2):29-35. https://doi.org/10.3390/md302029
Chicago/Turabian StyleTsukamoto, Sachiko, Keiichirou Koimaru, and Tomihisa Ohta. 2005. "Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale" Marine Drugs 3, no. 2: 29-35. https://doi.org/10.3390/md302029