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Article

Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line

by
Taiko Oda
1,*,
Michio Namikoshi
4,
Kyoko Akano
4,
Hisayoshi Kobayashi
5,
Yoshio Honma
3 and
Tadashi Kasahara
2
1
Department of Basic Biological Sciences, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan
2
Department of Biochemistry, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan
3
Institute of Radiopharmaceutical Chemistry, Kyoritsu College of Pharmacy, Shibakoen 1-chome, 5-30, Minato-ku, Tokyo, 105-8512, Japan
4
Department of Ocean Sciences, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan
5
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113- 0032, Japan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2005, 3(2), 64-73; https://doi.org/10.3390/md302064
Submission received: 4 March 2005 / Accepted: 2 June 2005 / Published: 2 June 2005
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Abstract

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at noncytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.
Keywords: verrucarin A; MAP kinase; HL-60; p38-phosphorylation; JNKphosphorylation verrucarin A; MAP kinase; HL-60; p38-phosphorylation; JNKphosphorylation

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MDPI and ACS Style

Oda, T.; Namikoshi, M.; Akano, K.; Kobayashi, H.; Honma, Y.; Kasahara, T. Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line. Mar. Drugs 2005, 3, 64-73. https://doi.org/10.3390/md302064

AMA Style

Oda T, Namikoshi M, Akano K, Kobayashi H, Honma Y, Kasahara T. Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line. Marine Drugs. 2005; 3(2):64-73. https://doi.org/10.3390/md302064

Chicago/Turabian Style

Oda, Taiko, Michio Namikoshi, Kyoko Akano, Hisayoshi Kobayashi, Yoshio Honma, and Tadashi Kasahara. 2005. "Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line" Marine Drugs 3, no. 2: 64-73. https://doi.org/10.3390/md302064

APA Style

Oda, T., Namikoshi, M., Akano, K., Kobayashi, H., Honma, Y., & Kasahara, T. (2005). Verrucarin A Inhibition of MAP Kinase Activation in a PMA-stimulated Promyelocytic Leukemia Cell Line. Marine Drugs, 3(2), 64-73. https://doi.org/10.3390/md302064

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