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Marine Drugs, Volume 22, Issue 4

April 2024 - 50 articles

Cover Story: Sea anemones are rich sources of bioactive molecules that are vital for therapeutic research due to their varied toxins and antimicrobial peptides. Acid extracts from Actinia equina were tested for antibacterial and antifungal activity, showing promising results with peptide fractions. Further purification via chromatography revealed peptides with broad-spectrum antimicrobial activity, which are effective against various pathogens, including multidrug-resistant strains. These peptides, Equinin A and B, were synthesized and tested in vitro, with Equinin B demonstrating significant antibacterial activity. Its gene structure suggests potential for applied research. Overall, sea anemones offer valuable resources for the development of novel antimicrobial agents with therapeutic potential. View this paper
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Articles (50)

  • Article
  • Open Access
4 Citations
3,221 Views
14 Pages

10 April 2024

Lumpfish (Cyclopterus lumpus) is an underutilized marine resource that is currently only being exploited for roe. Lumpfish skin was pre-treated with alkali (0.1M NaOH) and acid (0.1M HCl) at a skin to chemical ratio of 1:10 for 24 h at 5 °C to re...

  • Review
  • Open Access
14 Citations
6,822 Views
22 Pages

Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives

  • João Cotas,
  • Silvia Lomartire,
  • Leonel Pereira,
  • Ana Valado,
  • João Carlos Marques and
  • Ana M. M. Gonçalves

10 April 2024

Diabetes mellitus is a chronic metabolic condition marked by high blood glucose levels caused by inadequate insulin synthesis or poor insulin use. This condition affects millions of individuals worldwide and is linked to a variety of consequences, in...

  • Review
  • Open Access
27 Citations
4,840 Views
12 Pages

9 April 2024

Halophilic archaea, also termed haloarchaea, are a group of moderate and extreme halophilic microorganisms that constitute the major microbial populations in hypersaline environments. In these ecosystems, mainly aquatic, haloarchaea are constantly ex...

  • Article
  • Open Access
9 Citations
3,156 Views
14 Pages

9 April 2024

The nutritional and bioactive value of seaweeds is widely recognized, making them a valuable food source. To use seaweeds as food, drying and thermal treatments are required, but these treatments may have a negative impact on valuable bioactive compo...

  • Article
  • Open Access
6 Citations
2,841 Views
24 Pages

8 April 2024

(−)-Doliculide, a marine cyclodepsipeptide derived from the Japanese sea hare, Dolabella auricularia, exhibits potent cytotoxic properties, sparking interest in the field of synthetic chemistry. It is comprised of a peptide segment and a polyke...

  • Article
  • Open Access
1 Citations
2,370 Views
23 Pages

Tunable Oxidized-Chitin Hydrogels with Customizable Mechanical Properties by Metal or Hydrogen Ion Exposure

  • Angelica Mucaria,
  • Demetra Giuri,
  • Claudia Tomasini,
  • Giuseppe Falini and
  • Devis Montroni

3 April 2024

This study focuses on the optimization of chitin oxidation in C6 to carboxylic acid and its use to obtain a hydrogel with tunable resistance. After the optimization, water-soluble crystalline β-chitin fibrils (β-chitOx) with a degree of fun...

  • Article
  • Open Access
11 Citations
3,622 Views
21 Pages

Sea Urchin Food Waste into Bioactives: Collagen and Polyhydroxynaphtoquinones from P. lividus and S. granularis

  • Margherita Roncoroni,
  • Giordana Martinelli,
  • Stefano Farris,
  • Stefania Marzorati and
  • Michela Sugni

3 April 2024

Approximately 75,000 tons of different sea urchin species are globally harvested for their edible gonads. Applying a circular economy approach, we have recently demonstrated that non-edible parts of the Mediterranean Sea urchin Paracentrotus lividus...

  • Article
  • Open Access
7 Citations
3,460 Views
11 Pages

Content and Bioaccessibility of Minerals and Proteins in Fish-Bone Containing Side-Streams from Seafood Industries

  • Marie Bagge Jensen,
  • Jette Jakobsen,
  • Charlotte Jacobsen,
  • Jens J. Sloth,
  • Jone Ibarruri,
  • Carlos Bald,
  • Bruno Iñarra,
  • Niels Bøknæs and
  • Ann-Dorit Moltke Sørensen

3 April 2024

With the aim to upcycle fish side-streams, enzymatic hydrolysis is often applied to produce protein hydrolysates with bioactive properties or just as a protein source for food and feed. However, the production of hydrolysates generates a side-stream....

  • Article
  • Open Access
7 Citations
3,154 Views
14 Pages

31 March 2024

Bacillus cereus, a common food-borne pathogen, forms biofilms and generates virulence factors through a quorum sensing (QS) mechanism. In this study, six compounds (dankasterone A, demethylincisterol A3, zinnimidine, cyclo-(L-Val-L-Pro), cyclo-(L-Ile...

  • Article
  • Open Access
3 Citations
2,562 Views
12 Pages

Porous Nano-Fiber Structure of Modified Electrospun Chitosan GBR Membranes Improve Osteoblast Calcium Phosphate Deposition in Osteoblast-Fibroblast Co-Cultures

  • Hengjie Su,
  • Tomoko Fujiwara,
  • Omar Skalli,
  • Gretchen Schreyack Selders,
  • Ting Li,
  • Linna Mao and
  • Joel D. Bumgardner

30 March 2024

Desirable characteristics of electrospun chitosan membranes (ESCM) for guided bone regeneration are their nanofiber structure that mimics the extracellular fiber matrix and porosity for the exchange of signals between bone and soft tissue compartment...

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Mar. Drugs - ISSN 1660-3397