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Marine Drugs, Volume 21, Issue 9

September 2023 - 43 articles

Cover Story: Miniaturized cultivation profiling (MATRIX) and molecular network analysis of an Australian marine-derived fungus, Talaromyces sp. CMB-TU011, yielded the cycloheptapeptide hydroxamate talarolide A (1) together with three new analogues 24. Refinement of Marfey’s methodology allowed differentiation of N-Me-l-Ala from N-Me-d-Ala, and l-allo-Ile from l-Ile and l-Leu, and together with detailed spectroscopic analysis and chemical synthesis, permitted unambiguous re-assignment of the structure for 1 and assignment of structures to 24. Knowledge of talarolide cross-ring H-bond hydroxamate bridging revealed a nature-inspired approach to stabilizing and defining the conformation of cyclic peptides, and a potential means to enhance the chemical and biological properties including the oral bioavailability of bioactive peptides. View this paper
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Articles (43)

  • Article
  • Open Access
2 Citations
2,843 Views
13 Pages

Identification of a Shewanella halifaxensis Strain with Algicidal Effects on Red Tide Dinoflagellate Prorocentrum triestinum in Culture

  • Victoria Cruz-Balladares,
  • Vladimir Avalos,
  • Hernán Vera-Villalobos,
  • Henry Cameron,
  • Leonel Gonzalez,
  • Yanett Leyton and
  • Carlos Riquelme

21 September 2023

The dinoflagellate Prorocentrum triestinum forms high biomass blooms that discolor the water (red tides), which may pose a serious threat to marine fauna and aquaculture exploitations. In this study, the algicidal effect of a bacterial strain (0YLH)...

  • Article
  • Open Access
1 Citations
2,604 Views
15 Pages

Tandocyclinones A and B, Ether Bridged C-Glycosyl Benz[a]anthracenes from an Intertidal Zone Streptomyces sp.

  • Thanh-Hau Huynh,
  • Eun Seo Bae,
  • Bo Eun Heo,
  • Jayho Lee,
  • Joon Soo An,
  • Yun Kwon,
  • Sang-Jip Nam,
  • Ki-Bong Oh,
  • Jichan Jang and
  • Sang Kook Lee
  • + 1 author

21 September 2023

Two new proton-deficient metabolites, tandocyclinones A and B (1 and 2), were discovered via the chemical profiling of the Streptomyces sp. strain TDH03, which was isolated from a marine sediment sample collected from the intertidal mudflat in Tando...

  • Article
  • Open Access
4 Citations
2,362 Views
20 Pages

19 September 2023

Marine sponges usually host a wide array of secondary metabolites that play crucial roles in their biological interactions. The factors that influence the intraspecific variability in the metabolic profile of organisms, their production or ecological...

  • Article
  • Open Access
4 Citations
3,070 Views
13 Pages

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches

  • Tiago Ribeiro,
  • Kristín Jónsdóttir,
  • Rene Hernandez-Bautista,
  • Natália Gonçalves Silva,
  • Begoña Sánchez-Astráin,
  • Afshin Samadi,
  • Finnur F. Eiriksson,
  • Margrét Thorsteinsdóttir,
  • Siegfried Ussar and
  • Ralph Urbatzka

19 September 2023

Cyanobacteria have demonstrated their therapeutic potential for many human diseases. In this work, cyanobacterial extracts were screened for lipid reducing activity in zebrafish larvae and in fatty-acid-overloaded human hepatocytes, as well as for gl...

  • Article
  • Open Access
5 Citations
2,876 Views
18 Pages

Nutrient Deficiencies Impact on the Cellular and Metabolic Responses of Saxitoxin Producing Alexandrium minutum: A Transcriptomic Perspective

  • Muhamad Afiq Akbar,
  • Nurul Yuziana Mohd Yusof,
  • Gires Usup,
  • Asmat Ahmad,
  • Syarul Nataqain Baharum and
  • Hamidun Bunawan

18 September 2023

Dinoflagellate Alexandrium minutum Halim is commonly associated with harmful algal blooms (HABs) in tropical marine waters due to its saxitoxin production. However, limited information is available regarding the cellular and metabolic changes of A. m...

  • Review
  • Open Access
13 Citations
6,800 Views
19 Pages

Shark IgNAR: The Next Broad Application Antibody in Clinical Diagnoses and Tumor Therapies?

  • Xiaofeng Jiang,
  • Ling Sun,
  • Chengwu Hu,
  • Feijian Zheng,
  • Zhengbing Lyu and
  • Jianzhong Shao

16 September 2023

Antibodies represent a relatively mature detection means and serve as therapeutic drug carriers in the clinical diagnosis and treatment of cancer—among which monoclonal antibodies (mAbs) currently occupy a dominant position. However, the emerge...

  • Article
  • Open Access
6 Citations
2,709 Views
13 Pages

Effects of Temperature, Light and Salt on the Production of Fucoxanthin from Conticribra weissflogii

  • Feng Li,
  • Xiangyu Rui,
  • David Kwame Amenorfenyo,
  • Yao Pan,
  • Xianghu Huang and
  • Changling Li

16 September 2023

Fucoxanthin is a natural active substance derived from diatoms that is beneficial to the growth and immunity of humans and aquatic animals. Temperature, light and salinity are important environmental factors affecting the accumulation of diatom activ...

  • Article
  • Open Access
4 Citations
2,714 Views
13 Pages

Rifamycin-Related Polyketides from a Marine-Derived Bacterium Salinispora arenicola and Their Cytotoxic Activity

  • Cao Van Anh,
  • Jong Soon Kang,
  • Jeong-Wook Yang,
  • Joo-Hee Kwon,
  • Chang-Su Heo,
  • Hwa-Sun Lee and
  • Hee Jae Shin

15 September 2023

Eight rifamycin-related polyketides were isolated from the culture broth of a marine-derived bacterium Salinispora arenicola, including five known (2–5 and 8) and three new derivatives (1, 6, and 7). The structures of the new compounds were det...

  • Article
  • Open Access
8 Citations
2,883 Views
11 Pages

Anti-Inflammatory Halogenated Monoterpenes from the Red Alga Portieria hornemannii

  • Yuan-Jhong Wu,
  • Tzu-Yin Huang,
  • Chiung-Yao Huang,
  • Chi-Chen Lin,
  • Wei-Lung Wang,
  • Hui-Chi Huang,
  • Shang-Yin Vanson Liu,
  • Chih-Hua Chao and
  • Jyh-Horng Sheu

14 September 2023

The chemical investigation of a red alga Portieria hornemannii enabled the identification of three new halogenated monoterpenes (1–3) along with two previously identified metabolites (4 and 5). Their structures were determined by spectroscopic...

  • Article
  • Open Access
5 Citations
2,693 Views
16 Pages

14 September 2023

The incidence of diseases brought on by resistant strains of micro-organisms, including tuberculosis, is rising globally as a result of the rapid rise in pathogenic micro-organism resistance to antimicrobial treatments. Secondary metabolites with pot...

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Mar. Drugs - ISSN 1660-3397