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Marine Drugs, Volume 15, Issue 11

November 2017 - 34 articles

Cover Story: Shown on the cover is Agelas clathrodes, also known as the orange elephant ear sponge. This organism is representative of the 18 other species covered in our review. Agelas sponges have been popular for scientific study because, as can be seen in the cover photo, they stand out in their environment. Agelas species can be found on coral reefs throughout Oceania. Remarkably, there has been sustained study, spanning last 47 years, of their structurally diverse metabolites. We believe that the biosynthetic products isolated from Agelas are truly fascinating and while perusing our review you will be able to scan more than 291 structures, many of which possess hetero atom diversity along with powerful bioactivity properties. (Cover photo by Clay Wiseman, all rights reserved) View this paper
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Articles (34)

  • Short Note
  • Open Access
30 Citations
5,294 Views
8 Pages

Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

  • Xue-Mei Hou,
  • Ya-Hui Zhang,
  • Yang Hai,
  • Ji-Yong Zheng,
  • Yu-Cheng Gu,
  • Chang-Yun Wang and
  • Chang-Lun Shao

22 November 2017

A new centrosymmetric cyclohexapeptide, aspersymmetide A (1), together with a known peptide, asperphenamate (2), was isolated from the fungus Aspergillus versicolor isolated from a gorgonian coral Carijoa sp., collected from the South China Sea. The...

  • Article
  • Open Access
32 Citations
5,878 Views
18 Pages

High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers

  • Yunhai Yi,
  • Xinxin You,
  • Chao Bian,
  • Shixi Chen,
  • Zhao Lv,
  • Limei Qiu and
  • Qiong Shi

22 November 2017

Widespread existence of antimicrobial peptides (AMPs) has been reported in various animals with comprehensive biological activities, which is consistent with the important roles of AMPs as the first line of host defense system. However, no big-data-b...

  • Article
  • Open Access
17 Citations
6,693 Views
11 Pages

16 November 2017

The cationic antimicrobial peptide epinecidin-1 was identified from Epinephelus coioides and possesses multiple biological functions, including antibacterial, antifungal, anti-tumor, and immunomodulatory effects. In addition, epinecidin-1 suppresses...

  • Article
  • Open Access
178 Citations
14,005 Views
11 Pages

Proximate Composition and Nutritional Value of Three Macroalgae: Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcata

  • José M. Lorenzo,
  • Rubén Agregán,
  • Paulo E. S. Munekata,
  • Daniel Franco,
  • Javier Carballo,
  • Selin Şahin,
  • Ramón Lacomba and
  • Francisco J. Barba

15 November 2017

Proximate composition (moisture, protein, lipid and ash content) and nutritional value (fatty acid, amino acid and mineral profile) of three macroalgae (Ascophyllum nodosum, Fucus vesiculosus and Bifurcaria bifurcate) were studied. Chemical compositi...

  • Feature Paper
  • Review
  • Open Access
32 Citations
10,408 Views
34 Pages

The Oxepane Motif in Marine Drugs

  • Héctor Barbero,
  • Carlos Díez-Poza and
  • Asunción Barbero

15 November 2017

Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are p...

  • Article
  • Open Access
40 Citations
7,218 Views
16 Pages

Lactones from the Sponge-Derived Fungus Talaromyces rugulosus

  • Lisa Küppers,
  • Weaam Ebrahim,
  • Mona El-Neketi,
  • Ferhat C. Özkaya,
  • Attila Mándi,
  • Tibor Kurtán,
  • Raha S. Orfali,
  • Werner E. G. Müller,
  • Rudolf Hartmann and
  • Wenhan Lin
  • + 3 authors

14 November 2017

The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1–5), seven (3S)-resorcylide derivatives (6–...

  • Article
  • Open Access
45 Citations
6,255 Views
12 Pages

Asperlin Inhibits LPS-Evoked Foam Cell Formation and Prevents Atherosclerosis in ApoE−/− Mice

  • Yue Zhou,
  • Ran Chen,
  • Dong Liu,
  • Chongming Wu,
  • Peng Guo and
  • Wenhan Lin

14 November 2017

Asperlin is a marine-derived natural product with antifungal and anti-inflammatory activities in vitro. In the present study, we isolated asperlin from a marine Aspergillus versicolor LZD4403 fungus and investigated its anti-atherosclerotic effects i...

  • Article
  • Open Access
6 Citations
4,636 Views
12 Pages

12 November 2017

The marine microalgae Isochrysis are a good producer of natural docosahexaenoic acid (DHA). To better understand the patterns of DHA accumulation and distribution, two Isochrysis strains, CL153180 and CCMP462, were evaluated in this study. In a batch...

  • Feature Paper
  • Article
  • Open Access
18 Citations
5,591 Views
10 Pages

New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

  • Amin Mokhlesi,
  • Rudolf Hartmann,
  • Tibor Kurtán,
  • Horst Weber,
  • Wenhan Lin,
  • Chaidir Chaidir,
  • Werner E. G. Müller,
  • Georgios Daletos and
  • Peter Proksch

11 November 2017

Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported...

  • Article
  • Open Access
20 Citations
4,957 Views
9 Pages

Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59

  • Yang-Mei Zhang,
  • Bai-Lian Liu,
  • Xin-Heng Zheng,
  • Xiao-Jun Huang,
  • Hong-Yu Li,
  • Ying Zhang,
  • Ting-Ting Zhang,
  • Da-Yuan Sun,
  • Bi-Run Lin and
  • Guang-Xiong Zhou

10 November 2017

Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-...

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Mar. Drugs - ISSN 1660-3397