The Oxepane Motif in Marine Drugs
1
GIR MIOMeT, IU CINQUIMA/Inorganic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, Spain
2
Department of Organic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Mar. Drugs 2017, 15(11), 361; https://doi.org/10.3390/md15110361
Received: 29 September 2017
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Revised: 3 November 2017
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Accepted: 8 November 2017
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Published: 15 November 2017
(This article belongs to the Special Issue Bioactive Marine Natural Compounds with Heterocyclic Motifs in their Structure)
Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and show very important biological activities, many of them possessing remarkable cytotoxic properties against a wide range of cancer cell lines. Their rich chemical structures have attracted the attention of many researchers who have reported interesting synthetic approaches to these targets. This review covers the most prominent examples of these types of compounds, focusing the discussion on the isolation, structure determination, medicinal properties and total synthesis of these products.
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Keywords:
marine drugs; oxepanes; total synthesis; biological activity
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MDPI and ACS Style
Barbero, H.; Díez-Poza, C.; Barbero, A. The Oxepane Motif in Marine Drugs. Mar. Drugs 2017, 15, 361. https://doi.org/10.3390/md15110361
AMA Style
Barbero H, Díez-Poza C, Barbero A. The Oxepane Motif in Marine Drugs. Marine Drugs. 2017; 15(11):361. https://doi.org/10.3390/md15110361
Chicago/Turabian StyleBarbero, Héctor, Carlos Díez-Poza, and Asunción Barbero. 2017. "The Oxepane Motif in Marine Drugs" Marine Drugs 15, no. 11: 361. https://doi.org/10.3390/md15110361
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