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Medicina, Volume 58, Issue 7

July 2022 - 138 articles

Cover Story: Biomarkers are necessary for the diagnosis of Alzheimer’s disease (AD) and for advancing clinical trials for AD. The United States Food and Drug Administration (US FDA) has provided guidance for the definition of biomarkers and their contexts of use in drug development, qualitification, and implementation in clinical practice. The Common Alzheimer’s Disease Research Ontology (CADRO) defines known disease processes that comprise therapeutic targets for AD therapies and establishes a framework for AD treatment and biomarker development. Advances in biomarker development promise to provide key foundational information for progress toward new treatments for patients with AD. View this paper
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Articles (138)

  • Case Report
  • Open Access
4 Citations
2,982 Views
5 Pages

Scar-Free Laparoscopy in BRCA-Mutated Women

  • Stefano Restaino,
  • Angelo Finelli,
  • Giulia Pellecchia,
  • Anna Biasioli,
  • Jessica Mauro,
  • Carlo Ronsini,
  • Monica della Martina,
  • Martina Arcieri,
  • Luigi Della Corte and
  • Felice Sorrentino
  • + 2 authors

17 July 2022

Background and Objectives: BRCA 1 and 2 mutations have a cumulative risk of developing ovarian cancer at 70 years of 41% and 15%, respectively, while a cumulative risk of breast cancer by 80 years of age was 72% for BRCA1 mutation carriers and 69% fo...

  • Article
  • Open Access
32 Citations
11,668 Views
14 Pages

Anxiety and Depression in Women with Polycystic Ovary Syndrome

  • Paweł Dybciak,
  • Ewa Humeniuk,
  • Dorota Raczkiewicz,
  • Jan Krakowiak,
  • Artur Wdowiak and
  • Iwona Bojar

16 July 2022

Background and Objectives: Mental health disorders are often the consequence of hormonal disorders such as those accompanying polycystic ovary syndrome (PCOS), where changes in appearance and having to deal with a number of other problems occur due t...

  • Systematic Review
  • Open Access
17 Citations
4,084 Views
15 Pages

Vitamins C and D and COVID-19 Susceptibility, Severity and Progression: An Evidence Based Systematic Review

  • Filippo Migliorini,
  • Raju Vaishya,
  • Jörg Eschweiler,
  • Francesco Oliva,
  • Frank Hildebrand and
  • Nicola Maffulli

15 July 2022

Background and Objectives: Starting in early December 2019, the novel Coronavirus Disease (COVID-19) from infection with COVID-19 has caused a global pandemic. Many aspects of its pathogenesis and related clinical consequences are still unclear. Earl...

  • Article
  • Open Access
2 Citations
2,311 Views
11 Pages

Effects of Positive End-Expiratory Pressure on Intraocular Pressure during One-Lung Ventilation in the Lateral Decubitus Position—A Prospective Randomized Trial

  • Yong Shin Kim,
  • Kwon Hui Seo,
  • Yeon Soo Jeon,
  • Jang Hyeok In,
  • Hong Soo Jung,
  • Yoo Jung Park,
  • Eun Hwa Jun and
  • Eunju Yu

15 July 2022

Background and Objectives: The effect of positive end-expiratory pressure (PEEP) on intraocular pressure (IOP) is debatable. There have been no studies investigating the effects of PEEP on IOP during one-lung ventilation (OLV). We aimed to investigat...

  • Article
  • Open Access
16 Citations
3,977 Views
12 Pages

Emphysema Quantification Using Ultra-Low-Dose Chest CT: Efficacy of Deep Learning-Based Image Reconstruction

  • Jeong-A Yeom,
  • Ki-Uk Kim,
  • Minhee Hwang,
  • Ji-Won Lee,
  • Kun-Il Kim,
  • You-Seon Song,
  • In-Sook Lee and
  • Yeon-Joo Jeong

15 July 2022

Background and Objectives: Although reducing the radiation dose level is important during diagnostic computed tomography (CT) applications, effective image quality enhancement strategies are crucial to compensate for the degradation that is caused by...

  • Review
  • Open Access
13 Citations
4,678 Views
6 Pages

Mini-Review on the Harlequin Syndrome—A Rare Dysautonomic Manifestation Requiring Attention

  • Ioannis Mavroudis,
  • Ioana-Miruna Balmus,
  • Alin Ciobica,
  • Alina-Costina Luca,
  • Rumana Chowdhury,
  • Alin-Constantin Iordache,
  • Dragos Lucian Gorgan and
  • Iulian Radu

15 July 2022

Harlequin syndrome (HS) is a rare autonomic disorder. The causes and risk factors of the disease are not fully understood. Some cases of HS are associated with traumatic injuries, tumors, or vascular impairments of the head. Symptoms of HS can also o...

  • Case Report
  • Open Access
5 Citations
2,472 Views
6 Pages

Surgical Treatment Following Failed Medical Treatment of an Interstitial Pregnancy

  • Stefano Restaino,
  • Elena De Gennaro,
  • Stefano Floris,
  • Guglielmo Stabile,
  • Giulia Zinicola,
  • Felice Sorrentino,
  • Giuseppe Vizzielli and
  • Lorenza Driul

15 July 2022

Interstitial pregnancy (IP) is a type of ectopic pregnancy in which the embryo implants in the interstitial part of the Fallopian tube. It accounts for 2% of all ectopic pregnancies. Signs and symptoms appear later than the other forms of ectopic pre...

  • Systematic Review
  • Open Access
23 Citations
12,818 Views
34 Pages

The Low-Fluence Q-Switched Nd:YAG Laser Treatment for Melasma: A Systematic Review

  • Yeon Seok Lee,
  • Yu Jin Lee,
  • Jung Min Lee,
  • Tae Young Han,
  • June Hyunkyung Lee and
  • Jae Eun Choi

14 July 2022

Melasma is a common pigmentary disorder with a complex pathogenesis, of which the treatment is challenging. Conventional treatment often leads to inconsistent results with unexpected pigmentary side effects and high recurrence rates. Recently, the lo...

  • Communication
  • Open Access
2 Citations
2,666 Views
9 Pages

14 July 2022

Recently, it was demonstrated that copper complexes and 3,4-diaminopyridine can effectively reduce the activity of the botulinum neurotoxin light chain. The aim of the present study was to indicate that treatment with an antidote may have a major inf...

  • Article
  • Open Access
3 Citations
2,329 Views
6 Pages

Trends in the Incidence and Severity of Injuries Sustained by Riders of Electric Bikes and Powered Scooters: A Retrospective Cross-Sectional Study

  • Bahaa Haj Yahya,
  • Helena Demetriou,
  • Adi Zelnik,
  • Nir Cohen,
  • Michael J. Drescher,
  • Gavriel Chaushu and
  • Yafit Hamzani

14 July 2022

Background and Objectives: The worldwide increase in electric bike (E-bike) and powered scooter (P-scooter) use in recent years has been accompanied by an increase in associated injuries to riders. The aim of this study was to evaluate trends in the...

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Medicina - ISSN 1648-9144