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Current Issues in Molecular Biology, Volume 47, Issue 9

September 2025 - 111 articles

Cover Story: Mis-localization of modified RNA and non-coding RNA molecules within cell compartments is emerging as a critical driver of hematologic malignancies. The best-known example of intracellular mis-localized molecule is the mutated nucleophosmin 1 in AML, which shuttles in the cytoplasm and disrupts cellular homeostasis. In a similar way, aberrantly settled RNAs carrying regulatory modifications and misrouted non-coding RNAs compromise essential networks for hematopoiesis, favoring malignant transformation. Recent technological advances in epitranscriptomic mapping and discovery of inhibitors targeting RNA-modifying enzymes aiming to correct pathogenic marks enable unprecedented insights into RNA localization dynamics and promote the design of novel therapeutic strategies in the field. View this paper
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Articles (111)

  • Article
  • Open Access
682 Views
17 Pages

Geniposide Inhibits Oral Squamous Cell Carcinoma by Regulating PI3K-Akt Signaling-Mediated Apoptosis: A Multi-Method Validation Study

  • Xue Wang,
  • Jianbo Wang,
  • Hua Hua,
  • Ping Wei,
  • Xue Chen,
  • Yusheng Peng,
  • Li Liu,
  • Dongmei Yu,
  • Xiaozhou You and
  • Siye Yang

Gardenia jasminoides J.Ellis is an important medicinal and edible resource. The fruit of Gardenia jasminoides J.Ellis contains a natural iridoid called geniposide, which has the ability to dramatically suppress the growth of a number of cancer cell l...

  • Article
  • Open Access
641 Views
20 Pages

The increasing resistance to chemotherapeutic agents in lung cancer significantly contributes to its high mortality. Natural compounds such as acetyl-11-keto-β-boswellic acid (AKBA) have emerged as promising adjuncts to standard therapies. This...

  • Article
  • Open Access
656 Views
28 Pages

Proteomic Analysis of Low-Temperature Stress Response in Maize (Zea mays L.) at the Seedling Stage

  • Tao Yu,
  • Jianguo Zhang,
  • Xuena Ma,
  • Shiliang Cao,
  • Wenyue Li and
  • Gengbin Yang

Low temperature severely restricts maize seedling establishment and yield in northern China, but the proteomic basis of low-temperature tolerance in maize remains unclear. This study used TMT-labeled quantitative proteomics combined with data-indepen...

  • Article
  • Open Access
665 Views
10 Pages

miR-145-5p and miR-148b-3p Expression Is Inversely Associated with Pten Expression in Prostate Pathologies

  • Karla Lizbeth Morales Hernández,
  • Noemí García Magallanes,
  • Marco Alvarez Arrazola,
  • Fred Luque Ortega,
  • Martín Irigoyen Arredondo,
  • Fernando Bergez Hernandez and
  • Eliakym Arambula Meraz

Prostate cancer (PCa) represents a significant cause of cancer-associated mortality in the male population worldwide and constitutes a multifactorial disease influenced by genetic and epigenetic factors. Deregulation of genes such as AR and PTEN, as...

  • Article
  • Open Access
647 Views
19 Pages

Introduction: The ability of salt-processed Alismatis Rhizoma (SAR) (Alisma plantago-aquqtica L.) to nourish Yin and promote urination is stronger than that of Alismatis Rhizoma (AR). However, there are few studies focused on evaluating the quality o...

  • Retraction
  • Open Access
588 Views
2 Pages

RETRACTED: Haghmorad et al. Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses. Curr. Issues Mol. Biol. 2022, 44, 5728–5740

  • Dariush Haghmorad,
  • Bahman Yousefi,
  • Majid Eslami,
  • Ali Rashidy-Pour,
  • Mahdieh Tarahomi,
  • Maryam Jadid Tavaf,
  • Azita Soltanmohammadi,
  • Simin Zargarani,
  • Aleksandr Kamyshnyi and
  • Valentyn Oksenych

The journal retracts the article “Oral Administration of Myelin Oligodendrocyte Glycoprotein Attenuates Experimental Autoimmune Encephalomyelitis through Induction of Th2/Treg Cells and Suppression of Th1/Th17 Immune Responses” [...]

  • Review
  • Open Access
3,409 Views
22 Pages

Natural Products Targeting the Androgen Receptor Signaling Pathway: Therapeutic Potential and Mechanisms

  • Sitong Wu,
  • Esveidy Isabel Oceguera Nava,
  • Dennis Ashong,
  • Guanglin Chen and
  • Qiao-Hong Chen

The androgen receptor (AR) signaling pathway is the primary driver of prostate cancer initiation and progression, including the development of castration-resistant prostate cancer (CRPC). Because current AR-targeted therapies inevitably encounter dru...

  • Article
  • Open Access
1 Citations
720 Views
22 Pages

Bioactive Component Screening and Mechanistic Study of the Anti-Diabetic Activity of Lophatherum gracile Brongn Extract

  • Rong Wang,
  • Xuefeng Liu,
  • Kuan Yang,
  • Shaojing Liu,
  • Lili Yu,
  • Yunmei Chen,
  • Nana Wang,
  • Yaqi Hu and
  • Bei Qin

Type 2 diabetes mellitus (T2DM), a metabolic disorder defined by glucose and lipid metabolism dysregulation, has become a major global health issue. Hence, effective measures to prevent T2DM are urgently required. Lophatherum gracile Brongn (LGB) has...

  • Article
  • Open Access
751 Views
17 Pages

Pharmacological Potential of Arthrospira platensis in Mitigating Sub-Chronic Colitis: Redox Homeostasis and Gut Microbiota Modulation

  • Meriem Aziez,
  • Betitera Yanat,
  • Cristina Rodriguez-Diaz,
  • Ramona Suharoschi,
  • Romana Vulturar,
  • Simona-Codruta Heghes,
  • Nawel Guenaoui,
  • Awadh M. Ali,
  • Eduardo Garcia-Fuentes and
  • Noureddine Bribi

Inflammatory bowel diseases (IBDs) are complex disorders involving interconnected immune, oxidative, and microbial dysregulations. Arthrospira platensis (Spirulina) is a rich source of bioactive compounds with antioxidant, anti-inflammatory, and immu...

  • Article
  • Open Access
910 Views
15 Pages

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder described by the deposition of triglycerides in the liver, which primarily occurs due to insulin resistance and obesity. Thyroid hormone receptor alpha (THRA) is involved in metabolic...

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Curr. Issues Mol. Biol. - ISSN 1467-3045