Advances in Pharmacotherapeutic Strategies to Prevent Tumor Development, Progression and Treatment Resistance, 2nd Edition

Dear Colleagues,

Recent advances in our understanding of molecular mechanisms underlying cancer progression have promoted the de novo development of novel small molecules and facilitated drug repositioning, complementing contemporary therapeutic approaches for enhancing patient survival. Pharmacotherapeutics that target nonredundant pathways in tumor cells required for proliferation, survival, and unchecked self-renewal capacity have provided additional strategies for improving the standard of care in treating many forms of cancer. Moreover, appreciating the importance of targeting the stromal compartment (e.g., immune cells, fibroblasts, and adipocytes) has further exposed therapeutic liabilities in the tumor microenvironment, which may present additional options for preventing tumor cell growth and suppressing cancer cell resistance to therapeutics. Further identification and elaboration of necessary intracellular pathways and cell–cell signaling mechanisms may improve new pharmacotherapeutic approaches for preventing tumor development, progression, and treatment resistance.

This Special Issue of Current Issues in Molecular Biology is open for the submission of both original research articles and review articles focused on the advances in our understanding of actionable pharmacologic mechanisms for preventing cancer development and progression. Identifying and elaborating on these mechanisms may provide a path forward in improving patient care and outcomes.

Dr. Peter C. Hart
Guest Editor

Manuscript Submission Information

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