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Pharmaceuticals, Volume 18, Issue 9

September 2025 - 183 articles

Cover Story: The 1,3,4-thiadiazole scaffold has emerged as a privileged structure in medicinal chemistry due to its unique electronic features, balanced physicochemical properties, and broad pharmacological potential. Its ability to modulate enzymes, interact with receptors, and disrupt microbial pathways underlies diverse antibacterial and antifungal effects. In recent years, numerous 1,3,4-thiadiazole derivatives have been synthesized and evaluated, demonstrating high levels of activity against Gram-positive and Gram-negative bacteria as well as a wide range of fungal species. This review highlights recent advances in the design, synthesis, and biological evaluation of such compounds. View this paper
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Articles (183)

  • Article
  • Open Access
483 Views
27 Pages

17 September 2025

Background/Objectives: Magnetic drug targeting (MDT) using polyethene glycol (PEG)-coated magnetoresponsive nanoclusters (MNCs) can localize therapeutics, but washout from high-shear arterial flow limits efficacy. This study assesses how PEG molecula...

  • Article
  • Open Access
909 Views
15 Pages

Site-Specific Microparticle Inhalation Therapy: A New Approach to Nasopharyngeal Symptoms

  • Eride Quarta,
  • Fabio Sonvico,
  • Ignazio La Mantia,
  • Antonio Varricchio,
  • Lucia Gloria,
  • Massimiliano Minale,
  • Niccola Funel,
  • Francesca Buttini and
  • Attilio Varricchio

17 September 2025

Background/Objectives: Inhalable Microparticles (IMPs) are part of a currently invading field of medicine. In fact, the anatomical district of Rhinopharynx represents a bed for many different pathologies and infections, where the dimension of drug ae...

  • Review
  • Open Access
3 Citations
3,187 Views
27 Pages

Mesoporous Silica Nanoparticles as Drug Delivery Systems

  • Flórián Benkő,
  • Katalin Kristó and
  • Tamás Sovány

17 September 2025

Mesoporous silica nanocarriers (MSNs) have emerged as significant candidates in the pharmaceutical industry for drug delivery systems, suitable for a wide variety of drugs. Absorbing the active pharmaceutical ingredients (APIs) into the pores can be...

  • Article
  • Open Access
1 Citations
902 Views
25 Pages

Baicalin–Myricetin-Coated Selenium Nanoparticles Mitigate Pathology in an Aβ1-42 Mice Model of Alzheimer’s Disease

  • Rosa Martha Pérez Gutiérrez,
  • Julio Téllez Gómez,
  • José María Mota Flores,
  • Mónica Corea Téllez and
  • Alethia Muñiz Ramírez

17 September 2025

Background: Current Alzheimer’s disease (AD) treatments primarily focus on symptom management and offer limited potential to arrest disease progression. To address this limitation, we developed baicalin–myricetin (BM) functionalized selen...

  • Article
  • Open Access
1 Citations
1,067 Views
14 Pages

17 September 2025

Objective: This article investigated the structural characteristics, powder properties, and performance variations of co-processed pregelatinized starch (PS) and microcrystalline cellulose (MCC) at varying ratios. Methods: Scanning Electron Microscop...

  • Systematic Review
  • Open Access
903 Views
18 Pages

17 September 2025

Background: It remains unclear whether metformin, a widely used antidiabetic medication, has any influence on the survival outcomes or treatment-related toxicities of radiotherapy in cancer patients. Given metformin’s potential anti-cancer prop...

  • Article
  • Open Access
724 Views
15 Pages

17 September 2025

Background/Objective: Gallstone disease (cholelithiasis) is a prevalent hepatobiliary disorder with limited non-surgical therapeutic options. Sinapic acid (SINAP), a phenolic compound found in various dietary sources, has demonstrated anti-inflammato...

  • Review
  • Open Access
579 Views
28 Pages

Hybrid and Chimeric Heterocycles for the Inhibition of Carbonic Anhydrases

  • Niccolò Paoletti,
  • Simone Giovannuzzi and
  • Claudiu T. Supuran

16 September 2025

The design of multitarget drugs is a growing strategy to address complex and multifactorial diseases, and heterocycles play a major role in this approach. This review aims to critically analyze the role of heterocyclic scaffolds in the development of...

  • Article
  • Open Access
784 Views
19 Pages

The Senotherapeutic Effects of APPA (Apocynin [AP] and Paeonol [PA]) on Senescent Human Chondrocytes

  • Mercedes Fernández-Moreno,
  • Tamara Hermida-Gómez,
  • Carlos Vaamonde-Garcia,
  • Sara Paniagua-Barro,
  • Nicholas Larkins,
  • Alan Reynolds and
  • Francisco J. Blanco

16 September 2025

Background/Objectives: Osteoarthritis (OA) is a complex joint disease involving chronic inflammation, aging, and obesity, affecting nearly 6 million people worldwide. Senescent cells in OA are linked to increased inflammation, oxidative stress, and D...

  • Article
  • Open Access
779 Views
25 Pages

Lipoprotein(a)/CD36 Interaction Drives IL-6/RhoA-GTP Signaling and miRNA Epigenetic Regulation in Coronary Artery Spasm

  • Yen-Kuang Lin,
  • Tsung-Han Hsieh,
  • Chi-Tai Yeh,
  • Vijesh Kumar Yadav,
  • Iat-Hang Fong,
  • Kuang-Tai Kuo,
  • Nicholas G. Kounis,
  • Patrick Hu and
  • Ming-Yow Hung

16 September 2025

Background: Lipoprotein(a) [Lp(a)]-induced inflammation contributes to coronary artery spasm (CAS) by the contraction of vascular smooth muscle cells. However, the interaction between Lp(a) and soluble CD36 (sCD36)/interleukin (IL)-6/RAS Homolog Fami...

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Pharmaceuticals - ISSN 1424-8247