2026 June - 27 articles
One unreported eremophilane sesquiterpenoid, 1α-methoxy-3-oxo-8α-hydroxy-10αH- eremophila-7(11)-en-12,8β-olide (1), was isolated from Ligularia fischeri. The structure of 1 was identified by detailed 1D and 2D NMR and HRMS anal...
4-Methyl-N-(4-methylbenzyl)-N’-(4-methylbenzylidene)benzenesulfonohydrazide was synthesized via N-alkylation. The compound was characterized by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). Its molecular structure wa...
This short note presents a new molecule isolated and characterized from the reaction of uranyl nitrate with the PCP-type pincer ligand 1,3-bis(ditertbutylphosphinomethyl)benzene in the presence of UV light under ambient conditions. The new dinuclear...
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We report the synthesis of the new compound 2-chloro-4,5,6,7-tetrafluoro-2-(methylthio)-1H-indene-1,3(2H)-dione (Compound 3), which presents an important type of fluoro-containing heterocycles and is a useful intermediate product in organic synthesis...
The Saudi Arabian Red Sea has been a focus of ongoing scientific exploration due to its extensive, largely untapped marine biodiversity, particularly marine sponges. Marine sponges have long been recognised as a valuable source of unique compounds. I...
The Delphinium albocoeruleum Maxim is a perennial herbaceous plant of the Ranunculaceae family, genus Delphinium. It typically grows in well-drained alpine meadows or shrublands at elevations of 2500–4000 m, which shapes the species’ uniq...
We report a highly chemoselective N-sulfonylation of 3-(methylthio)-1H-1,2,4-triazol-5-amine with 4-nitrobenzenesulfonyl chloride promoted by N,N-diisopropylethylamine in acetonitrile under mild conditions. This transformation selectively affords N-(...
Imidazolidin-2-thiones are versatile sulfur-containing heterocycles with broad biological relevance. The synthesis of (3aR,7aR)-1,3-bis(4-aminobenzyl)octahydro-2H-benzo[d]imidazole-2-thione (an imidazolidin-2-thione derivative) from trans-(R, R)-diam...
In this report, we describe the synthesis of two new celastrol derivatives featuring aryl-substituted 1,2,3-triazole fragments attached to the celastrol scaffold via an ester linkage. The target compounds, incorporating 4-methoxyphenyl and p-tert-but...
Fluoroalkyl-substituted organoboron compounds are valuable building blocks for organic synthesis and for the development of functional molecules in medicinal chemistry, agrochemicals, and materials science. Building on our previous work on difluorome...
The title compound, 3-(diphenylamino)-4-ethoxycyclobut-3-ene-1,2-dione (6), was prepared by reaction of diphenylamine (2) with diethyl squarate (DES; 5) as part of our ongoing studies on monosquarate-amides. Following purification and recrystallisati...
A novel bio-capable method has been implemented for the synthesis of newly substituted derivatives of perimidine using Fe3O4@nano-cellulose/Ti(IV) as a magnetic, sustainable, and eco-friendly Lewis acid nanocatalyst. The catalyst was thoroughly chara...
In the present work, we synthesize 2-(4-allyl-2-methoxyphenoxy)-1-(4-phenylpiperazin-1-yl)ethan-1-one, a semisynthetic derivative of the natural product eugenol. The compound was synthesized via a three-step synthetic pathway involving esterification...
Rhodamine 110 (R110) peptide conjugates are widely used fluorogenic substrates in proteolytic assays; however, their inherent symmetry results in two identical hydrolysis sites, complicating their application as well-defined substrates. Here, we repo...
This study addresses the synthesis of a new liquid crystalline compound featuring a 3,5-disubstituted isoxazoline and a 1,3-dioxolan-2-one ring, and renewable aromatic building blocks derived from vanilin and benzoic acid. The target compound was syn...
The formation of side products is often unavoidable in organic synthesis; however, analyzing these secondary species provides practical insights into reaction pathways, mechanisms, and competing processes. This understanding is essential for optimizi...
4-Methyl- (1) and 4-ethyl-8-hydroxyquinoline (2) crystallize from a mixture of diethyl ether and chloroform in the triclinic space group P
A new tert-butyldimethylsilyl-protected polyoxygenated chalcone was prepared by Claisen–Schmidt condensation of suitably protected acetophenone and benzaldehyde derivatives. Treatment of this chalcone with m-chloroperbenzoic acid (mCPBA) afford...
The conversion of 2,5-difluorobenzylamine to N-(2,5-difluorobenzylidene)-1-(2,5-difluorobenzyl)methanimine using an oxoammonium salt bearing the nitrate anion is reported. The reaction is operationally simple, and the product is obtained with good yi...
The BODIPY core has emerged as a versatile scaffold for the design of photoremovable protecting groups (PPGs). Herein, we report the synthesis of a novel BODIPY–epinephrine conjugate linked via a carbamate moiety, enabling light-triggered relea...
A novel nitrogen-containing heterocyclic compound, 4-(6-Chloropyridin-3-yl)-6-cyclopropylpyrimidin-2-amine, was designed and synthesized using 6-chloropyridin-3-aldehyde and cyclopropyl methyl ketone as starting materials. The structure of the target...
The compound (Z)-6-heneicosen-11-one, a possible pheromone component of the hickory tussock moth, Lophocampa caryae, and a known pheromone component of the Douglas fir tussock moth, Orgyia pseudotsugata, was synthesized by a new four-step procedure w...
The ferrocidiphenol family brings together anticancer molecules featuring a [ferrocene-alkene-(p-phenol)2] motif that can form upon oxidation a quinone methide metabolite targeting cellular proteins. Adding an imide group (imido-ferrocidiphenol) dram...
The synthesis of three novel, valuable bioconjugates obtained by coupling cholesterol bromoacetate with pyridine derivatives via an SN2 reaction was successfully carried out. Each of the products was fully characterized by magnetic nuclear resonance...
A new compound, 2-(2-methoxyphenyl)-4-methyl-6-nitroquinoline, was obtained via Suzuki reaction. An unexpected side product, 2-(2-methoxyphenyl)-4-methylquinolin-6-amine, was isolated. The structures of the novel compounds were confirmed by 1H, 13C a...
Herein, starting from (R)-(+)-α-methylbenzylamine, we report an efficient synthesis and full characterization of a new (R)-3-(1-hydroxyethylidene)-1-(1-phenylethyl)piperidine-2,4-dione, a new tetramic acid analog. The key steps involved a non-c...
