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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals

by
Aurelio Nieto-Trujillo
1,
Rosendo Luria-Pérez
2,
Francisco Cruz-Sosa
3,
Carmen Zepeda-Gómez
4,
María G. González-Pedroza
4,
Cristina Burrola-Aguilar
1,
Armando Sunny
5,
José Correa-Basurto
6,
José A. Guerrero-Analco
7,
Juan L. Monribot-Villanueva
7 and
María Elena Estrada-Zúñiga
1,*
1
Centro de Investigación en Recursos Bióticos, Facultad de Ciencias, Universidad Autónoma del Estado de México, Carretera Toluca-Ixtlahuaca km 14.5, San Cayetano, Toluca 50295, Mexico
2
Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de México Federico Gómez, Dr. Márquez No 162, Col. Doctores, Cuauhtémoc, Mexico City 06720, Mexico
3
Departamento de Biotecnología, Universidad Autónoma Metropolitana-Unidad Iztapalapa, Av. Ferrocarril San Rafael Atlixco No 186, Leyes de Reforma 1ra Sección, Iztapalapa, Mexico City 09310, Mexico
4
Facultad de Ciencias, Universidad Autónoma del Estado de México, Campus El Cerrillo, Piedras Blancas, Carretera Toluca-Ixtlahuaca km. 15.5, Toluca 50200, Mexico
5
Centro de Investigación en Ciencias Biológicas Aplicadas, Facultad de Ciencias, Universidad Autónoma del Estado de México, Carretera Toluca-Ixtlahuaca km 14.5, San Cayetano, Toluca 50295, Mexico
6
Laboratorio de Modelado Molecular, Bioinformática y Diseño de Fármacos, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón S/N, Casco de Santo Tomás, Mexico City 11340, Mexico
7
Laboratorio de Química de Productos Naturales, Red de Estudios Moleculares Avanzados, Instituto de Ecología, A.C., Carretera Antigua a Coatepec 351, El Haya, Xalapa 91073, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(15), 7209; https://doi.org/10.3390/ijms26157209
Submission received: 20 June 2025 / Revised: 17 July 2025 / Accepted: 21 July 2025 / Published: 25 July 2025
(This article belongs to the Special Issue Plant Phenolic Accumulation and Application in Human Diseases)
Versions Notes

Abstract

Tanacetum parthenium (Asteraceae) has been traditionally used worldwide for medicinal purposes, and some of its therapeutic uses have been attributed to the pharmacological effects of its secondary metabolites. The root culture of this species might represent a sustainable source of several pharmacologically active compounds. The biomass of a root T. parthenium culture was extracted with methanol and fractionated using column chromatography. Three selected fractions (4TP, 5TP, and 8TP) were analyzed via spectrophotometric, chromatographic, and mass spectrometry techniques and in vitro pharmacological assays. The greatest values for total phenolic and phenolic acid contents and antibacterial activity against Escherichia coli were determined for 4TP. The highest values for total flavonoid and sesquiterpene lactone contents, antioxidant potential, and α-amylase inhibitory effect were determined for 8TP. The antibacterial effect against Staphylococcus aureus was not significantly different among the three fractions. The root culture of T. parthenium is a potential source of several metabolites, such as phenolic acids, fatty acids, coumarins, sesquiterpenoids, and triterpenoids, which are capable of exerting α-amylase inhibition and antioxidant, antibacterial, and cytotoxic effects. Among eight phenolic compounds detected and quantified in the fractions, chlorogenic acid was the most abundant.
Keywords: antioxidant; antibacterial; cytotoxic; α-amylase inhibition; secondary metabolites; targeted metabolomics; untargeted metabolomics antioxidant; antibacterial; cytotoxic; α-amylase inhibition; secondary metabolites; targeted metabolomics; untargeted metabolomics

Share and Cite

MDPI and ACS Style

Nieto-Trujillo, A.; Luria-Pérez, R.; Cruz-Sosa, F.; Zepeda-Gómez, C.; González-Pedroza, M.G.; Burrola-Aguilar, C.; Sunny, A.; Correa-Basurto, J.; Guerrero-Analco, J.A.; Monribot-Villanueva, J.L.; et al. Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals. Int. J. Mol. Sci. 2025, 26, 7209. https://doi.org/10.3390/ijms26157209

AMA Style

Nieto-Trujillo A, Luria-Pérez R, Cruz-Sosa F, Zepeda-Gómez C, González-Pedroza MG, Burrola-Aguilar C, Sunny A, Correa-Basurto J, Guerrero-Analco JA, Monribot-Villanueva JL, et al. Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals. International Journal of Molecular Sciences. 2025; 26(15):7209. https://doi.org/10.3390/ijms26157209

Chicago/Turabian Style

Nieto-Trujillo, Aurelio, Rosendo Luria-Pérez, Francisco Cruz-Sosa, Carmen Zepeda-Gómez, María G. González-Pedroza, Cristina Burrola-Aguilar, Armando Sunny, José Correa-Basurto, José A. Guerrero-Analco, Juan L. Monribot-Villanueva, and et al. 2025. "Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals" International Journal of Molecular Sciences 26, no. 15: 7209. https://doi.org/10.3390/ijms26157209

APA Style

Nieto-Trujillo, A., Luria-Pérez, R., Cruz-Sosa, F., Zepeda-Gómez, C., González-Pedroza, M. G., Burrola-Aguilar, C., Sunny, A., Correa-Basurto, J., Guerrero-Analco, J. A., Monribot-Villanueva, J. L., & Estrada-Zúñiga, M. E. (2025). Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals. International Journal of Molecular Sciences, 26(15), 7209. https://doi.org/10.3390/ijms26157209

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