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International Journal of Molecular Sciences, Volume 25, Issue 8

2024 April-2 - 443 articles

Cover Story: Iron is an essential element in human brain physiology but is detrimental upon abnormal accumulation, which is observed in the brains of patients with neurodegenerative proteinopathies, including Alzheimer’s disease, progressive supranuclear palsy, Parkinson’s disease, and multiple system atrophy. The comprehensive involvement of iron in multiple disease pathomechanisms challenges the current understanding of its functions in disease pathogenesis. Relevant disease-specific observations are deconstructed and summarized under four distinct hypotheses: 1) iron deposition is a consequence of protein pathology, 2) iron promotes protein pathology, 3) iron protects from or hinders protein pathology, and 4) the deposition of iron and protein pathology contribute parallelly to the pathogenesis. View this paper
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Articles (443)

  • Review
  • Open Access
3 Citations
3,464 Views
13 Pages

The biologically significant phenomenon that the fetus can survive immune attacks from the mother has been demonstrated in mammals. The survival mechanism depends on the fetus and placenta actively defending themselves against attacks by maternal T c...

  • Review
  • Open Access
8 Citations
20,962 Views
18 Pages

Coenzyme Q10 and Autoimmune Disorders: An Overview

  • David Mantle and
  • Iain P. Hargreaves

Some 90 autoimmune disorders have been described in medical literature, affecting most of the tissues within the body. Autoimmune disorders may be difficult to treat, and there is a need to develop novel therapeutic strategies for these disorders. Au...

  • Article
  • Open Access
2,105 Views
13 Pages

K+-Driven Cl/HCO3 Exchange Mediated by Slc4a8 and Slc4a10

  • Gaspar Peña-Münzenmayer,
  • Alvin T. George,
  • Nuria Llontop,
  • Yuliet Mazola,
  • Natalia Apablaza,
  • Carlos Spichiger,
  • Sebastián Brauchi,
  • José Sarmiento,
  • Leandro Zúñiga and
  • Marcelo A. Catalán
  • + 1 author

Slc4a genes encode various types of transporters, including Na+-HCO3− cotransporters, Cl−/HCO3− exchangers, or Na+-driven Cl−/HCO3− exchangers. Previous research has revealed that Slc4a9 (Ae4) functions as a Cl−/HC...

  • Article
  • Open Access
2,310 Views
13 Pages

Free Radical–Associated Gene Signature Predicts Survival in Sepsis Patients

  • Anlin Feng,
  • Marissa D. Pokharel,
  • Ying Liang,
  • Wenli Ma,
  • Saurabh Aggarwal,
  • Stephen M. Black and
  • Ting Wang

Sepsis continues to overwhelm hospital systems with its high mortality rate and prevalence. A strategy to reduce the strain of sepsis on hospital systems is to develop a diagnostic/prognostic measure that identifies patients who are more susceptible...

  • Article
  • Open Access
9 Citations
2,709 Views
14 Pages

With the continuous rise of the sea cucumber aquaculture industry in China, the tropical sea cucumber aquaculture industry is also improving. However, research on the gut microorganisms of tropical sea cucumbers in captivity is scarce. In this study,...

  • Article
  • Open Access
3 Citations
2,562 Views
21 Pages

Role of Protein Tyrosine Phosphatase Receptor Type E (PTPRE) in Chemoresistant Retinoblastoma

  • Lars Mohren,
  • Annika Doege,
  • Natalia Miroschnikov,
  • Oliver Dräger,
  • Maike Anna Busch and
  • Nicole Dünker

Protein tyrosine phosphatase receptor type E (PTPRE) is a member of the “classical” protein tyrosine phosphatase subfamily and regulates a variety of cellular processes in a tissue-specific manner by antagonizing the function of protein t...

  • Article
  • Open Access
2 Citations
2,622 Views
13 Pages

APOE ε2-Carriers Are Associated with an Increased Risk of Primary Angle-Closure Glaucoma in Patients of Saudi Origin

  • Altaf A. Kondkar,
  • Taif A. Azad,
  • Tahira Sultan,
  • Tanvir Khatlani,
  • Abdulaziz A. Alshehri,
  • Rakesh Radhakrishnan,
  • Glenn P. Lobo,
  • Ehab Alsirhy,
  • Faisal A. Almobarak and
  • Saleh A. Al-Obeidan
  • + 1 author

This study investigated the association between apolipoprotein E (APOE) gene polymorphisms (rs429358 and rs7412) and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG) in a Saudi cohort. Genotyping of 437 DNA samples (251 cont...

  • Article
  • Open Access
5 Citations
2,058 Views
17 Pages

EspP2 Regulates the Adhesion of Glaesserella parasuis via Rap1 Signaling Pathway

  • Xinwei Tang,
  • Shiyu Xu,
  • Zhen Yang,
  • Kang Wang,
  • Ke Dai,
  • Yiwen Zhang,
  • Bangdi Hu,
  • Yu Wang,
  • Sanjie Cao and
  • Yiping Wen
  • + 6 authors

Different levels of EspP2 expression are seen in strains of Glaesserella parasuis with high and low pathogenicity. As a potential virulence factor for G. parasuis, the pathogenic mechanism of EspP2 in infection of host cells is not clear. To begin to...

  • Article
  • Open Access
4 Citations
2,810 Views
17 Pages

Transcription Factor McHB7 Improves Ice Plant Drought Tolerance through ABA Signaling Pathway

  • Xuemei Zhang,
  • Zihan Cheng,
  • Gaofeng Fan,
  • Dan Zhu,
  • Bowen Tan,
  • Tingbo Jiang and
  • Sixue Chen

As global climate change continues, drought episodes have become increasingly frequent. Studying plant stress tolerance is urgently needed to ensure food security. The common ice plant is one of the model halophyte plants for plant stress biology res...

  • Article
  • Open Access
1 Citations
2,211 Views
20 Pages

The Long-Acting Serine Protease Inhibitor mPEG-SPA-MDSPI16 Alleviates LPS-Induced Acute Lung Injury

  • Jingrui Chen,
  • Xinjun Zhou,
  • Nan Dai,
  • Xiaoyu Liu,
  • Shihan Liu,
  • Haipeng Zhang,
  • Lingcong Kong and
  • Hongxia Ma

Anti-inflammatory drugs have become the second-largest class of common drugs after anti-infective drugs in animal clinical care worldwide and are often combined with other drugs to treat fever and viral diseases caused by various factors. In our prev...

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Int. J. Mol. Sci. - ISSN 1422-0067