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International Journal of Molecular Sciences, Volume 25, Issue 21

November-1 2024 - 521 articles

Cover Story: Tumor and immune cells are regulated via various molecular mechanisms involving intricate transcriptional and epigenetic networks. Epigenetic processes influence chromatin structure and accessibility, thus governing gene expression, replication, and DNA damage repair. However, aberrations within epigenetic signatures are frequently observed in cancer. One of the key epigenetic marks is the trimethylation of histone 3 at lysine 9 (H3K9me3). Dysregulated H3K9me3 deposition disrupts multiple pathways, including immune signaling, and consequently converts cold tumors to hot ones. Here, we review the existing literature to synthesize the available information on the influence of H3K9me3 writers, erasers, and readers on the response to immunotherapy. View this paper
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Articles (521)

  • Article
  • Open Access
1 Citations
1,667 Views
20 Pages

Evaluation of a Novel Mechanical Device for the Production of Microfragmented Adipose Tissue for Veterinary Regenerative Medicine: A Proof-of-Concept

  • Priscilla Berni,
  • Valentina Andreoli,
  • Virna Conti,
  • Roberto Ramoni,
  • Giuseppina Basini,
  • Gabriele Scattini,
  • Luisa Pascucci,
  • Martina Pellegrini,
  • Maurizio Del Bue and
  • Gian Paolo Squassino
  • + 6 authors

4 November 2024

Therapies based on mesenchymal stromal cells (MSCs) have become one of the most significant advancements in veterinary regenerative medicine. The isolation of MSCs is usually performed by enzymatic digestion and requires variable times for cell expan...

  • Article
  • Open Access
1 Citations
2,100 Views
27 Pages

Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2/tNOX) Is a Potential Prognostic Marker in Primary Malignant Melanoma and May Serve as a Therapeutic Target

  • Matti Böcker,
  • Eftychia Chatziioannou,
  • Heike Niessner,
  • Constanze Hirn,
  • Christian Busch,
  • Kristian Ikenberg,
  • Hubert Kalbacher,
  • Rupert Handgretinger and
  • Tobias Sinnberg

4 November 2024

With an increasing incidence of malignant melanoma, new prognostic biomarkers for clinical decision making have become more important. In this study, we evaluated the role of ecto-NOX disulfide-thiol exchanger 2 (ENOX2/tNOX), a cancer- and growth-ass...

  • Article
  • Open Access
2 Citations
1,777 Views
19 Pages

4 November 2024

Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissu...

  • Article
  • Open Access
2 Citations
1,485 Views
18 Pages

Potential Cryptic Diversity in the Genus Scoliodon (Carcharhiniformes: Carcharhinidae): Insights from Mitochondrial Genome Sequencing

  • Peiyuan Ye,
  • Yuanxiang Miao,
  • Chen Wang,
  • Pichai Sonchaeng,
  • Sarawut Siriwong,
  • Shaobo Chen,
  • Junjie Wang and
  • Xiao Chen

4 November 2024

Scoliodon is a genus of small placental sharks living in offshore waters. For a long time, the genus was considered a monotypic genus until a valid species, Scoliodon macrorhynchos, was confirmed in 2010. However, S. muelleri in the same study was no...

  • Review
  • Open Access
26 Citations
5,950 Views
28 Pages

Molecular and Cellular Mechanisms Involved in the Pathophysiology of Retinal Vascular Disease—Interplay Between Inflammation and Oxidative Stress

  • Jovana V. Srejovic,
  • Maja D. Muric,
  • Vladimir Lj. Jakovljevic,
  • Ivan M. Srejovic,
  • Suncica B. Sreckovic,
  • Nenad T. Petrovic,
  • Dusan Z. Todorovic,
  • Sergey B. Bolevich and
  • Tatjana S. Sarenac Vulovic

4 November 2024

Retinal vascular diseases encompass several retinal disorders, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and retinal vascular occlusion; these disorders are classified as similar groups of disorders...

  • Article
  • Open Access
1 Citations
1,616 Views
11 Pages

The Association of TP53, BCL2, BAX and NOXA SNPs and Laryngeal Squamous Cell Carcinoma Development

  • Tomas Jakstas,
  • Agne Bartnykaite,
  • Evaldas Padervinskis,
  • Aurelija Vegiene,
  • Elona Juozaityte,
  • Virgilijus Uloza and
  • Rasa Ugenskiene

4 November 2024

Head and neck cancer is the seventh leading cancer diagnosis worldwide. One of the most common cancers in the head and neck region is laryngeal cancer. In past years, the incidence of laryngeal squamous cell carcinoma has risen by 23%, and despite pr...

  • Communication
  • Open Access
1 Citations
1,925 Views
9 Pages

Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome

  • Patrícia Silva,
  • Inês Francisco,
  • Bruno Filipe,
  • Pedro Lage,
  • Isadora Rosa,
  • Sofia Fernandes,
  • Ricardo Fonseca,
  • Paula Rodrigues,
  • Joana Parreira and
  • Isabel Claro
  • + 1 author

4 November 2024

Serrated polyposis syndrome (SPS) is characterized by the development of multiple colorectal serrated polyps and increased predisposition to colorectal cancer (CRC). However, the molecular basis of SPS, especially in cases presenting family history o...

  • Article
  • Open Access
2 Citations
2,315 Views
29 Pages

AI-Assisted Identification of Primary and Secondary Metabolomic Markers for Postoperative Delirium

  • Vladimir A. Ivanisenko,
  • Artem D. Rogachev,
  • Aelita-Luiza A. Makarova,
  • Nikita V. Basov,
  • Evgeniy V. Gaisler,
  • Irina N. Kuzmicheva,
  • Pavel S. Demenkov,
  • Artur S. Venzel,
  • Timofey V. Ivanisenko and
  • Evgenia A. Antropova
  • + 5 authors

4 November 2024

Despite considerable investigative efforts, the molecular mechanisms of postoperative delirium (POD) remain unresolved. The present investigation employs innovative methodologies for identifying potential primary and secondary metabolic markers of PO...

  • Review
  • Open Access
9 Citations
13,203 Views
36 Pages

Advancements in Therapeutic Approaches for Degenerative Tendinopathy: Evaluating Efficacy and Challenges

  • Vivek Kumar Morya,
  • Hamzah Shahid,
  • Jun Lang,
  • Mi Kyung Kwak,
  • Sin-Hye Park and
  • Kyu-Cheol Noh

4 November 2024

Degenerative tendinopathy results from the accumulation of minor injuries following unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is prolonged and varies between individuals, making it susceptible to reinjury....

  • Article
  • Open Access
3 Citations
2,514 Views
22 Pages

Uncovering Metal-Decorated TiO2 Photocatalysts for Ciprofloxacin Degradation—A Combined Experimental and DFT Study

  • Marija Kovačević,
  • Marija Simić,
  • Sanja Živković,
  • Miloš Milović,
  • Ljiljana Tolić Stojadinović,
  • Dubravka Relić and
  • Dragana Vasić Anićijević

4 November 2024

Optimization of the efficiency of the photocatalytic degradation of organic and pharmaceutical pollutants represents a matter of fundamental and practical interest. The present experimental and DFT study deals with evaluation of OH radical binding en...

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Int. J. Mol. Sci. - ISSN 1422-0067