New Molecular Insights into Red Blood Cell Dynamics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 3750
Special Issue Editor
Interests: sickle-cell disease (SCD); thalassaemia; RBC enzymes deficiencies; hereditary membranopathies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This chapter will explore the latest molecular insights into the dynamics of red blood cells (RBCs), emphasizing the implications for understanding diseases and advancing medical treatments. We will delve into the biogenesis of RBCs, their lifecycle, and the molecular mechanisms governing their function and degradation. Recent advances in molecular biology and genetics will be highlighted, showcasing how these findings could revolutionize therapies for blood disorders.
Introduction to Red Blood Cells
Brief overview of RBCs’ function and importance
- Transport of oxygen and carbon dioxide;
- Role in homeostasis and immune system interactions.
Historical perspective
- Evolution of understanding from early microscopic observations to molecular insights.
Biogenesis and Development
Erythropoiesis
- Detailed molecular pathways involved in RBC maturation from hematopoietic stem cells;
- Role of erythropoietin and other growth factors.
Genetic regulation
- Key genes and their regulatory mechanisms;
- Impact of mutations on RBC development.
RBCs’ Lifespan and Degradation
Mechanisms of aging in RBCs
- Changes in membrane composition and flexibility;
- Role of oxidative stress and autophagy.
Clearance from circulation
- Interaction with macrophages in the spleen;
- Molecular signals that tag aged or damaged RBCs for removal.
Molecular Pathways in Disease
Common RBC disorders
- Anemias: Iron deficiency, sickle cell disease, thalassemias;
- Hereditary spherocytosis and other membrane defects.
Molecular targets for therapy
- Recent breakthroughs in targeted treatments;
- Potential for gene therapy and CRISPR/Cas9 applications.
Frontiers in RBC Research
Innovative diagnostic techniques
- High-throughput sequencing and proteomics;
- Advanced imaging techniques.
Emerging therapies
- Novel pharmacological approaches;
- Regenerative medicine and stem cell therapy.
Conclusions
Summary of key findings
- Recap of molecular insights and their implications for disease management;
- Future directions;
- Predictions for new research areas;
- Potential impacts of emerging technologies on RBC research.
This chapter aims to provide a comprehensive update on the molecular dynamics of red blood cells, bringing together recent research that sheds light on their development, function, and role in disease. By exploring both foundational concepts and cutting-edge advances, the chapter will serve as a valuable resource for students and researchers alike, paving the way for future discoveries and innovations in the field of hematology.
Prof. Dr. Joan-Lluis Vives-Corrons
Guest Editor
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Keywords
- erythropoiesis
- oxidative stress
- genetic regulation
- anemia
- molecular therapy
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