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International Journal of Molecular Sciences, Volume 25, Issue 20

2024 October-2 - 465 articles

Cover Story: In the context of a circular economy, this study explores the valorization of blueberry pomace as a source of bioactive compounds through sustainable extraction methods. Microwave-assisted extraction (MAE) and subcritical water extraction (MASWE) were used sequentially to obtain two fractions: MAE 1°, rich in anthocyanins with potential as a natural pigment and anti-diabetic/anti-viral agent, and MASWE 2°, high in phenolics with possible applications in Alzheimer’s, melanogenesis, oxidative stress protection, and anthocyanin preservation. The extract characteristics were compared with a conventional method (MeOH-HCl in reflux), and the protocol’s sustainability was assessed using green metrics, highlighting its environmental impact and efficiency while showcasing an eco-friendly approach to converting agri-food waste into high-value products for multiple sectors. View this paper
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Articles (465)

  • Article
  • Open Access
2 Citations
5,485 Views
24 Pages

The Degradation of Absorbable Surgical Threads in Body Fluids: Insights from Infrared Spectroscopy Studies

  • Katarzyna Merkel,
  • Katarzyna Grzybowska,
  • Aleksandra Strach and
  • Marcin Gierek

21 October 2024

This study investigates the degradation of six different types of absorbable surgical threads commonly used in clinical practice, focusing on their response to exposure to physiological fluids. The threads were subjected to hydrolytic and enzymatic d...

  • Article
  • Open Access
4 Citations
4,264 Views
17 Pages

New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans

  • Zsofia Gal,
  • Dora Torok,
  • Xenia Gonda,
  • Nora Eszlari,
  • Ian Muir Anderson,
  • Bill Deakin,
  • Peter Petschner,
  • Gabriella Juhasz and
  • Gyorgy Bagdy

21 October 2024

Mounting evidence supports the key role of the disrupted integrity of the blood-brain barrier (BBB) in stress- and inflammation-associated depression. We assumed that variations in genes regulating the expression and coding proteins constructing and...

  • Article
  • Open Access
3 Citations
2,205 Views
16 Pages

21 October 2024

Ginsenoside Ro, as one of the few oleanane-type ginsenosides, is well known for its unique molecular structure and biological activities. Currently, research on the biosynthesis of ginsenoside Ro is still in its early stages. Therefore, the establish...

  • Article
  • Open Access
5 Citations
2,070 Views
16 Pages

Genome-Wide Identification of the Cyclic Nucleotide-Gated Ion Channel Gene Family and Expression Profiles Under Low-Temperature Stress in Luffa cylindrica L.

  • Jianting Liu,
  • Yuqian Wang,
  • Lijuan Peng,
  • Mindong Chen,
  • Xinru Ye,
  • Yongping Li,
  • Zuliang Li,
  • Qingfang Wen and
  • Haisheng Zhu

21 October 2024

Cyclic nucleotide-gated ion channels (CNGCs) are cell membrane channel proteins for calcium ions. They have been reported to play important roles in survival and in the responses to environmental factors in various plants. However, little is known ab...

  • Review
  • Open Access
8 Citations
4,420 Views
13 Pages

Regenerative Inflammation: The Mechanism Explained from the Perspective of Buffy-Coat Protagonism and Macrophage Polarization

  • Rubens Andrade Martins,
  • Fábio Ramos Costa,
  • Luyddy Pires,
  • Márcia Santos,
  • Gabriel Silva Santos,
  • João Vitor Lana,
  • Bruno Ramos Costa,
  • Napoliane Santos,
  • Alex Pontes de Macedo and
  • José Fábio Lana
  • + 1 author

21 October 2024

The buffy-coat, a layer of leukocytes and platelets obtained from peripheral blood centrifugation, plays a crucial role in tissue regeneration and the modulation of inflammatory responses. This article explores the mechanisms of regenerative inflamma...

  • Article
  • Open Access
3 Citations
1,976 Views
17 Pages

21 October 2024

Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 diabetes (T...

  • Article
  • Open Access
6 Citations
3,499 Views
12 Pages

21 October 2024

Tacrolimus (TAC) is a commonly used immunosuppressive drug in solid organ transplantation. Pharmacogenetics has been demonstrated before to be decisive in TAC pharmacotherapy. The CYP3A5*3 variant has been reported to be the main determinant of TAC d...

  • Review
  • Open Access
37 Citations
9,632 Views
47 Pages

Photodynamic Therapy: Past, Current, and Future

  • David Aebisher,
  • Sara Czech,
  • Klaudia Dynarowicz,
  • Maciej Misiołek,
  • Katarzyna Komosińska-Vassev,
  • Aleksandra Kawczyk-Krupka and
  • Dorota Bartusik-Aebisher

21 October 2024

The Greek roots of the word “photodynamic” are as follows: “phos” (φω~ς) means “light” and “dynamis” (δύναμις) means “force” or “pow...

  • Article
  • Open Access
5 Citations
2,524 Views
17 Pages

21 October 2024

Endothelial dysfunction, which is marked by a reduction in nitric oxide (NO) production or an imbalance in relaxing and contracting factor levels, exacerbates atherosclerosis by promoting the production of cell adhesion molecules and cytokines. This...

  • Article
  • Open Access
1,633 Views
27 Pages

Precision Oncology in Older Cancer Patients: A Single-Center Experience

  • Meret Petitat-Berli,
  • Marie Knufinke,
  • Michèle Voegeli,
  • Martina Sonderegger,
  • Bettina Seifert,
  • Elena Diana Chiru,
  • Pirmin Haeuptle,
  • Lisanne van’t Walderveen,
  • Robert Rosenberg and
  • Marcus Vetter
  • + 7 authors

21 October 2024

In the last two decades, next-generation sequencing (NGS) has facilitated enormous progress in cancer medicine, in both diagnosis and treatment. However, the usefulness of NGS in older cancer patients is unclear. To determine the role of NGS in older...

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Int. J. Mol. Sci. - ISSN 1422-0067