Cardiac Diseases: Molecular Mechanisms and Therapeutic Strategies

Dear Colleagues,

Ion channels, membrane proteins that facilitate the passage of various ions across cell membranes, play a pivotal role in numerous physiological functions, notably neuronal signaling and the contraction of cardiac muscles. The activation kinetics of ion channels usually commence with a stimulus triggering a coordinated conformational change in the channel protein. In the context of cardiac diseases, this process holds significant relevance. The resulting conformational change leads to the opening of a channel pore, selectively allowing ions to traverse the cell membrane. Notably, the molecular behavior of ion channels can be influenced by various agents, including neurotransmitters, hormones, and drugs.

Within the realm of cardiac diseases, understanding the cellular and molecular aspects of these fundamental processes becomes paramount. Cardiac diseases involve intricate research in the field of cardiac cellular electrophysiology. State-of-the-art molecular and biophysical techniques are applied to cardiac myocytes obtained from diverse experimental models to unravel the complexities of heart function. We encourage contributions employing innovative approaches to elucidate molecular mechanisms, thereby enhancing our understanding of the molecular basis of cardiac diseases from a multiscale perspective.

Dr. Jader Santos Cruz
Guest Editor

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• electrophysiology
• cardiac diseases
• electrical signals
• electrical remodeling
• channels dysfunction