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International Journal of Molecular Sciences, Volume 25, Issue 22

2024 November-2 - 627 articles

Cover Story: Chronic spontaneous urticaria (CSU) is defined by itchy wheals and/or angioedema lasting at least 6 weeks, driven by prolonged mast cell activation. Platelet-Activating Factor (PAF), a potent lipid mediator, plays a key role in CSU pathogenesis, distinct from IgE-mediated mechanisms. This cover image shows PAF signaling through its receptor (PAFR), activating Gi and Gq proteins, leading to calcium mobilization, protein kinase C (PKC) activation, and β-arrestin-mediated receptor internalization. These pathways drive mast cell degranulation, increased vascular permeability, persistent inflammation, and sensory nerve activation, central to CSU. PAF sustains chronic itch and inflammation through mast cells, basophils, neutrophils, endothelial cells, and sensory neurons. Targeting PAF pathways provides promising strategies for antihistamine-resistant CSU. View this paper
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Articles (627)

  • Review
  • Open Access
3 Citations
2,689 Views
19 Pages

20 November 2024

Mycobacterium tuberculosis (M. tb) is a remarkably versatile pathogen that possesses a unique ability to counteract the host’s defence mechanisms to control the infection. Several mycobacterial protein kinases and phosphatases were found to pla...

  • Article
  • Open Access
2 Citations
2,090 Views
19 Pages

Effect of Pre-Sowing Seed Stimulation on Maize Seedling Vigour

  • Paulina Pipiak,
  • Katarzyna Sieczyńska,
  • Dorota Gendaszewska and
  • Monika Skwarek-Fadecka

20 November 2024

The aim of this study was to investigate the effects of treating maize (Zea mays L.) seeds with fish collagen hydrolysate (FC) and keratin (KE) derived from animal waste by-products of leather and meat production, as well as poly(hexamethylene biguan...

  • Review
  • Open Access
14 Citations
6,234 Views
17 Pages

The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review

  • Camilla Bertoni,
  • Cecilia Pini,
  • Alessandra Mazzocchi,
  • Carlo Agostoni and
  • Paolo Brambilla

20 November 2024

The present review investigates the relationship between polyunsaturated fatty acids (PUFAs) and mental health disorders, such as dementia, psychosis, schizophrenia, Alzheimer’s disease, anorexia nervosa, and impairment problems in animals and...

  • Article
  • Open Access
2 Citations
1,598 Views
21 Pages

20 November 2024

Dysregulation in the stress-response system as a result of genetical mutation can provoke the manifestation of affective disorders under stress conditions. Mutations in the human DISC1 gene is one of the main risk factors of affective disorders. It w...

  • Article
  • Open Access
2 Citations
1,176 Views
14 Pages

Effect of Constant Illumination on the Morphofunctional State and Rhythmostasis of Rat Livers at Experimental Toxic Injury

  • Sevil A. Grabeklis,
  • Maria A. Kozlova,
  • Lyudmila M. Mikhaleva,
  • Alexander M. Dygai,
  • Rositsa A. Vandysheva,
  • Anna I. Anurkina and
  • David A. Areshidze

20 November 2024

The effect of dark deprivation on the morphofunctional state and rhythmostasis of the liver under CCl4 toxic exposure has been studied. The relevance of this study is due to the fact that the hepatotoxic effect of carbon tetrachloride on the liver is...

  • Article
  • Open Access
3 Citations
1,684 Views
15 Pages

Long Noncoding RNA lncRNA-3 Recruits PRC2 for MyoD1 Silencing to Suppress Muscle Regeneration During Aging

  • Zong-Kang Zhang,
  • Daogang Guan,
  • Jintao Xu,
  • Xiaofang Li,
  • Ning Zhang,
  • Shanshan Yao,
  • Ge Zhang and
  • Bao-Ting Zhang

20 November 2024

Lowered muscle regenerative capacity in the elderly greatly contributes to the development of multiple diseases. The specific roles of long noncoding RNAs (lncRNAs) in muscle regenerative capacity during aging remain unknown. Here, we identify an ele...

  • Article
  • Open Access
2 Citations
2,305 Views
24 Pages

Novel Exosomal miRNA Expression in Irradiated Human Keratinocytes

  • Hebah Almujally,
  • Nizar Abuharfeil and
  • Aseel Sharaireh

20 November 2024

The epidermis, the outer layer of the skin, relies on a delicate balance of cell growth and keratinocyte differentiation for its function and renewal. Recent research has shed light on exosomes’ role in facilitating skin communication by transf...

  • Article
  • Open Access
3 Citations
2,164 Views
31 Pages

Multi-Spectroscopic and Molecular Modeling Studies of Interactions Between Anionic Porphyrin and Human Serum Albumin

  • Tadeusz Strózik,
  • Marian Wolszczak,
  • Maria Hilczer,
  • Magdalena Pawlak,
  • Tomasz Wasiak,
  • Piotr Wardęga,
  • Maksim Ionov and
  • Maria Bryszewska

20 November 2024

The subject of this study is the interaction between 5,10,15,20-tetrakis (4-sulfonatophenyl)–porphyrin (TSPP), a potential photosensitizer for photodynamic therapy (PDT) and radiotherapy, and human serum albumin (HSA), a crucial protein in the...

  • Article
  • Open Access
2 Citations
1,675 Views
11 Pages

Coronavirus Disease 2019-Associated Thrombotic Microangiopathy: A Single-Center Experience

  • Marija Malgaj Vrečko,
  • Andreja Aleš-Rigler,
  • Špela Borštnar and
  • Željka Večerić-Haler

20 November 2024

Coronavirus disease 2019 (COVID-19) can lead to various multisystem disorders, including thrombotic microangiopathy (TMA). We present here eight patients with COVID-19-associated TMA who were treated at our center. Our aim was to summarize the demogr...

  • Article
  • Open Access
1 Citations
2,257 Views
20 Pages

Male Wistar Rats Chronically Fed with a High-Fat Diet Develop Inflammatory and Ionic Transport Angiotensin-(3–4)-Sensitive Myocardial Lesions but Preserve Echocardiographic Parameters

  • Thuany Crisóstomo,
  • Rafael Luzes,
  • Matheus Leonardo Lima Gonçalves,
  • Marco Antônio Estrela Pardal,
  • Humberto Muzi-Filho,
  • Glória Costa-Sarmento,
  • Debora B. Mello and
  • Adalberto Vieyra

20 November 2024

The central aim of this study was to investigate whether male Wistar rats chronically fed a high-fat diet (HFD) over 106 days present high levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and Na+ and Ca2+ transport altera...

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Int. J. Mol. Sci. - ISSN 1422-0067