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Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases

by 1,2,3,*, 1,2, 1,2,3 and 1,2,3
1
Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy
2
Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Orbassano (TO), Italy
3
National Institute of Neuroscience (INN), 10125 Turin, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3719; https://doi.org/10.3390/ijms21103719
Received: 4 May 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 25 May 2020
(This article belongs to the Special Issue Targeting Mitochondria in Aging and Disease)
Mitochondria play a central role in a plethora of processes related to the maintenance of cellular homeostasis and genomic integrity. They contribute to preserving the optimal functioning of cells and protecting them from potential DNA damage which could result in mutations and disease. However, perturbations of the system due to senescence or environmental factors induce alterations of the physiological balance and lead to the impairment of mitochondrial functions. After the description of the crucial roles of mitochondria for cell survival and activity, the core of this review focuses on the “mitochondrial switch” which occurs at the onset of neuronal degeneration. We dissect the pathways related to mitochondrial dysfunctions which are shared among the most frequent or disabling neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, Amyotrophic Lateral Sclerosis, and Spinal Muscular Atrophy. Can mitochondrial dysfunctions (affecting their morphology and activities) represent the early event eliciting the shift towards pathological neurobiological processes? Can mitochondria represent a common target against neurodegeneration? We also review here the drugs that target mitochondria in neurodegenerative diseases. View Full-Text
Keywords: mitochondria; cellular homeostasis; neurodegenerative diseases; motor neuron diseases; neurodegeneration; oxidative stress; mitochondria biogenesis and dynamics; mitochondria targeting drugs mitochondria; cellular homeostasis; neurodegenerative diseases; motor neuron diseases; neurodegeneration; oxidative stress; mitochondria biogenesis and dynamics; mitochondria targeting drugs
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MDPI and ACS Style

Stanga, S.; Caretto, A.; Boido, M.; Vercelli, A. Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases. Int. J. Mol. Sci. 2020, 21, 3719.

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