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Open AccessArticle

Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model

1
Department of Pediatrics, Hallym University and Kangdong Sacred Heart Hospital, Seoul 05355, Korea
2
Department of Medical Science, Chungnam National University, Daejeon 35015, Korea
3
Department of Anatomy and Cell Biology, Chungnam National University, Daejeon 35015, Korea
4
Brain Research Institute, Chungnam National University, Daejeon 35015, Korea
5
Department of Pediatrics, Chungnam National University Hospital, Daejeon 35015, Korea
6
Department of Neurology, Chungnam National University and Sejong Hospital, Sejong 30099, Korea
7
Department of Pediatrics, Hallym University and Dongtan Sacred Heart Hospital, Hwasung Gyunggi-do 18450, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(10), 3703; https://doi.org/10.3390/ijms21103703
Received: 29 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 24 May 2020
(This article belongs to the Section Molecular Neurobiology)
Neonatal ischemic stroke has a higher incidence than childhood stroke. Seizures are the first sign for the need for clinical assessment in neonates, but many questions remain regarding treatments and follow-up modalities. In the absence of a known pathophysiological mechanism, only supportive care is currently provided. Stroke-induced microglia activation and neuroinflammation are believed to play a central role in the pathological progression of neonatal ischemic stroke. We induced a photothrombotic infarction with Rose Bengal in neonatal rats to investigate the effects of pre- and post-treatment with Aspirin (ASA), Clopidogrel (Clop), and Coenzyme Q10 (CoQ10), which are known for their neuroprotective effects in adult stroke. Pre-stroke medication ameliorates cerebral ischemic injury and reduces infarct volume by reducing microglia activation, cellular reactive oxygen species (ROS) production, and cytokine release. Post-stroke administration of ASA, Clop, and CoQ10 increased motor function and reduced the volume of infarction, and the statistical evidence was stronger than that seen in the pre-stroke treatment. In this study, we demonstrated that ASA, Clop, and CoQ10 treatment before and after the stroke reduced the scope of stroke lesions and increased behavioral activity. It suggests that ASA, Clop, and CoQ10 medication could significantly have neuroprotective effects in the neonates who have suffered strokes. View Full-Text
Keywords: photothrombotic stroke; neonatal period; Aspirin; clopidogrel; Coenzyme Q10; neuroprotection photothrombotic stroke; neonatal period; Aspirin; clopidogrel; Coenzyme Q10; neuroprotection
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MDPI and ACS Style

Yi, Y.Y.; Shin, H.J.; Choi, S.G.; Kang, J.W.; Song, H.-J.; Kim, S.K.; Kim, D.W. Preventive Effects of Neuroprotective Agents in a Neonatal Rat of Photothrombotic Stroke Model. Int. J. Mol. Sci. 2020, 21, 3703.

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