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Molecules, Volume 30, Issue 4

February-2 2025 - 218 articles

Cover Story: Many pathogenic bacteria can form biofilms, where cells become attached to a surface and are entrapped in a matrix of exopolysaccharides, extracellular DNA, and proteins. Such sessile bacteria are extremely resistant to antibiotics and to the immune system. About two-thirds of all human bacterial infections are now believed to be caused by biofilms, highlighting the need for novel agents that can prevent or reverse biofilm formation. In this work, a 96-well plate screening approach and different detection strategies were used to measure the antibiofilm activity and selectivity of a series of peptides based on the naturally occurring cationic Trp-rich WWW peptide tritrpticin. Structural changes in the peptide backbone and the introduction of a nonnatural amino acid were shown to improve the clinical potential of several peptide variants. View this paper
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Articles (218)

  • Article
  • Open Access
5 Citations
1,481 Views
14 Pages

Construction and Regulation of Polymer@Silica Microspheres with Double-Shell Hollow Structures

  • Mingxiu Jiang,
  • Yuanyuan Yang,
  • Jiawei Feng,
  • Zhaopan Wang and
  • Wei Deng

18 February 2025

Microspheres with well-defined hollow structures have been attracting interest due to their unique morphology and fascinating properties. Herein, a strategy for morphology and size control of hollow polymer@silica microspheres is proposed. Multilayer...

  • Article
  • Open Access
19 Citations
1,576 Views
13 Pages

Rational Design of Metal-Free Nitrogen-Doped Carbon for Controllable Reduction of CO2 to Syngas

  • Guangbin An,
  • Kang Wang,
  • Min Yang,
  • Jiye Zhang,
  • Haijian Zhong,
  • Liang Wang and
  • Huazhang Guo

18 February 2025

The electrocatalytic reduction of CO2 (ECO2RR) to syngas with tunable CO/H2 ratios offers a promising route for sustainable energy conversion and chemical production. Here, we report a series of N-doped carbon black (NCBx) catalysts with tailored nit...

  • Article
  • Open Access
1 Citations
1,371 Views
15 Pages

18 February 2025

Several polyphenol-rich Terminalia species (Combretaceae) are known to accelerate wound healing. Recently, the Omani medicinal plant Anogeissus dhofarica (now Terminalia dhofarica) was attributed to the genus Terminalia based on phylogenetic studies....

  • Article
  • Open Access
2 Citations
845 Views
18 Pages

18 February 2025

Two bis-ruthenium(II) complexes, namely N,N′-{5,17-diamino-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arene}-bis-[dichloro-(p-cymene)-ruthenium(II)] (1) and N,N′-{5,11-diamino-4(24),6(10),12(16), 18(22)-...

  • Article
  • Open Access
753 Views
12 Pages

The Production and Characterization of an Aminolyzed Polyhydroxyalkanoate Membrane and Its Cytocompatibility with Osteoblasts

  • Qiulan Luo,
  • Fuming Zou,
  • Dongjuan Yang,
  • Yongping Huang,
  • Dajie Xian,
  • Ying Nie,
  • Zhenxia Zhang,
  • Yuzhong Zheng,
  • Yaqun Liu and
  • Fei Zhou
  • + 4 authors

18 February 2025

Polyhydroxyalkanoates (PHAs), recognized as a medical biomaterial, have been proven to promote cell proliferation and tissue repair. PHA has a variety of forms: PHB, PHV, PHHx, and PHBHHx, etc. In this study, PHBHHx was selected as the precursor to f...

  • Article
  • Open Access
1,264 Views
15 Pages

Structural Identification of Physalis alkekengi L. Polysaccharides

  • Yun Zhang,
  • Xuan Wen,
  • Neng Xu,
  • Hongyan Fu,
  • Ge Lv,
  • Wenjie Yu,
  • Lina Wei and
  • Lin Zhao

18 February 2025

Physalis alkekengi L. fruit polysaccharides can reduce blood sugar, regulate blood lipids, and improve intestinal flora structure. However, the specific polysaccharide components exerting these effects are unclear. In this study, we extracted, separa...

  • Review
  • Open Access
6 Citations
5,999 Views
14 Pages

18 February 2025

Advancements in biological and medical science are intricately linked to the biological central dogma. In recent years, gene editing techniques, especially CRISPR/Cas systems, have emerged as powerful tools for modifying genetic information, suppleme...

  • Article
  • Open Access
1 Citations
1,770 Views
26 Pages

An Appealing, Robust Access to Furo-Fused Heteropolycycles

  • Alice Benzi,
  • Lara Bianchi,
  • Gianluca Giorgi,
  • Giovanni Lentini,
  • Massimo Maccagno,
  • Guglielmo Marcantoni Taddei,
  • Giovanni Petrillo and
  • Cinzia Tavani

18 February 2025

Recently, nitrostilbenes characterized by two different or differently substituted aryl moieties, obtainable from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines, have proved, by means of a stepwise double coupling with phenolic-type...

  • Article
  • Open Access
1 Citations
1,714 Views
23 Pages

Diplopterys pubipetala (Malpighiaceae): Insights into Antioxidant, Antibacterial, and Antifungal Activities with Chemical Composition Analysis via UHPLC-MS/MS and GC/MS

  • Veronica de Melo Sacramento,
  • Vanessa de Andrade Royo,
  • Pedro Henrique Fonseca Veloso,
  • Kamila Soares Freitas Souto,
  • Alisson Samuel Portes Caldeira,
  • Carlos Henrique Gomes Martins,
  • Sara Lemes de Souza,
  • Ezequias Pessoa de Siqueira,
  • Fernando Ribeiro Cassiano and
  • Afrânio Farias de Melo Júnior
  • + 3 authors

18 February 2025

Diplopterys pubipetala (Malpighiaceae) is a liana native to the Brazilian Cerrado biome, traditionally used in Ayahuasca preparations. Despite its cultural importance, research on its chemical composition and biological activities, which may have the...

  • Article
  • Open Access
1,775 Views
18 Pages

18 February 2025

Aquilaria spp. are a highly valuable plant species found in the Chinese herbal medicine and agarwood fragrance supplement industries for fumigation, combustion and perfume. The phytochemical composition of agarwood oils (extracts) was derived from Aq...

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Molecules - ISSN 1420-3049