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Molecules, Volume 27, Issue 17

2022 September-1 - 386 articles

Cover Story: Two new azobenzene heptamethine cyanine conjugates exist as dispersed monomeric molecules in methanol and exhibit near-infrared (NIR) cyanine absorption and fluorescence. Both conjugates form non-emissive cyanine H-aggregates in water, but the addition of cucurbit[7]uril (CB7) induces dye deaggregation and a large increase in cyanine NIR fluorescence emission intensity. CB7 encapsulates the protonated azonium tautomer of the 4-(N,N-dimethylamino)azobenzene component of each azobenzene–cyanine conjugate and produces a distinctive new absorption band at 534 nm. These complexes are quite hydrophilic, which suggests that CB7 can be used as a supramolecular additive to solubilize this new family of NIR azobenzene–cyanine conjugates for future biomedical applications. CB7 encapsulation can finetune their solubility and pharmaceutical profile. View this paper
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Articles (386)

  • Article
  • Open Access
17 Citations
6,023 Views
12 Pages

5 September 2022

The aim of this study was to develop a method for the determination of glyphosate, its metabolite aminomethylphosphonic acid (AMPA), and glufosinate ammonium residues in beebread samples, which could then be used to assess bees’ exposure to the...

(This article belongs to the Special Issue Analysis of Residues in Environmental Samples)
  • Article
  • Open Access
14 Citations
3,963 Views
22 Pages

Determination and Removal of Selected Pharmaceuticals and Total Organic Carbon from Surface Water by Aluminum Chlorohydrate Coagulant

  • Joanna Kuc,
  • Maciej Thomas,
  • Iwona Grochowalska,
  • Rafał Kulczyk,
  • Gabriela Mikosz,
  • Fabian Mrózek,
  • Dagmara Janik,
  • Justyna Korta and
  • Karolina Cwynar

5 September 2022

In the present research, the removal of Total Organic Carbon (TOC) and erythromycin (ERY), fluoxetine (FLX), amoxicillin (AMO), colistin (COL), ethynylestradiol (EE), and diclofenac (DIC) from surface water by coagulation is studied. The concentratio...

(This article belongs to the Section Green Chemistry)
  • Article
  • Open Access
7 Citations
3,408 Views
26 Pages

5 September 2022

The pathogenic form of thermophilic Naegleria sp. i.e., Naegleria fowleri, also known as brain eating amoeba, causes primary amoebic encephalitis (PAM) with a >97% fatality rate. To date, there are no specific drugs identified to treat this diseas...

(This article belongs to the Section Chemical Biology)
  • Feature Paper
  • Review
  • Open Access
11 Citations
3,562 Views
19 Pages

Electrospun Polymer Materials with Fungicidal Activity: A Review

  • Nasko Nachev,
  • Mariya Spasova,
  • Nevena Manolova,
  • Iliya Rashkov and
  • Mladen Naydenov

5 September 2022

In recent years, there has been special interest in innovative technologies such as polymer melt or solution electrospinning, electrospraying, centrifugal electrospinning, coaxial electrospinning, and others. Applying these electrokinetic methods, mi...

(This article belongs to the Special Issue Exclusive Review Papers in Green Chemistry)
  • Article
  • Open Access
5 Citations
13,400 Views
10 Pages

Sequential Processing Enables 17% All-Polymer Solar Cells via Non-Halogen Organic Solvent

  • Chaoyue Zhao,
  • Lihong Wang,
  • Guoping Zhang,
  • Yajie Wang,
  • Ruiyu Hu,
  • Hui Huang,
  • Mingxia Qiu,
  • Shunpu Li and
  • Guangye Zhang

5 September 2022

All-polymer solar cells (All-PSCs), whose electron donor and acceptors are both polymeric materials, have attracted great research attention in the past few years. However, most all-PSC devices with top-of-the-line efficiencies are processed from chl...

(This article belongs to the Special Issue Molecular Semiconductors for Organic and Perovskite Solar Cells)
  • Article
  • Open Access
18 Citations
3,941 Views
11 Pages

5 September 2022

This study established a QuEChERS high-performance liquid chromatography/tandem triple-quadrupole mass spectrometry method for determining azoxystrobin, pyraclostrobin, picoxystrobin, difenoconazole, chlorantraniliprole, imidacloprid, and cyantranili...

(This article belongs to the Special Issue Food Analysis in the 21st Century: Challenges and Possibilities)
  • Article
  • Open Access
7 Citations
3,374 Views
16 Pages

Synthesis of Cyano-Benzylidene Xanthene Synthons Using a Diprotic Brønsted Acid Catalyst, and Their Application as Efficient Inhibitors of Aluminum Corrosion in Alkaline Solutions

  • Mohammed A. Amin,
  • Gaber A. M. Mersal,
  • Morad M. El-Hendawy,
  • Abdallah A. Shaltout,
  • Ali Badawi,
  • Johan Boman,
  • Adil A. Gobouri,
  • Murat Saracoglu,
  • Fatma Kandemirli and
  • Mohamed E. Khalifa
  • + 2 authors

5 September 2022

Novel cyano-benzylidene xanthene derivatives were synthesized using one-pot and condensation reactions. A diprotic Brønsted acid (i.e., oxalic acid) was used as an effective catalyst for the promotion of the synthesis process of the new starti...

(This article belongs to the Special Issue Chemistry of Corrosion Inhibitors)
  • Article
  • Open Access
13 Citations
3,866 Views
10 Pages

Design of Pd–Zn Bimetal MOF Nanosheets and MOF-Derived Pd3.9Zn6.1/CNS Catalyst for Selective Hydrogenation of Acetylene under Simulated Front-End Conditions

  • Xinxiang Cao,
  • Ruijian Tong,
  • Siye Tang,
  • Ben W. -L. Jang,
  • Arash Mirjalili,
  • Jiayi Li,
  • Xining Guo,
  • Jingyi Zhang,
  • Jiaxue Hu and
  • Xin Meng

5 September 2022

Novel zinc–palladium–porphyrin bimetal metal–organic framework (MOF) nanosheets were directly synthesized by coordination chelation between Zn(II) and Pd(II) tetra(4-carboxyphenyl)porphin (TCPP(Pd)) using a solvothermal method. Furt...

(This article belongs to the Special Issue Emerging Catalytic, Energetic, and Inorganic Nonmetallic Materials)
  • Article
  • Open Access
11 Citations
3,802 Views
22 Pages

New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture

  • Alexey Sulimov,
  • Ivan Ilin,
  • Danil Kutov,
  • Khidmet Shikhaliev,
  • Dmitriy Shcherbakov,
  • Oleg Pyankov,
  • Nadezhda Stolpovskaya,
  • Svetlana Medvedeva and
  • Vladimir Sulimov

5 September 2022

Candidates to being inhibitors of the main protease (Mpro) of SARS-CoV-2 were selected from the database of Voronezh State University using molecular modeling. The database contained approximately 19,000 compounds represented by more than 41,000 liga...

(This article belongs to the Special Issue Recent Trends on Enzymes Inhibitors and Activators in Drug Research 3.0)
  • Article
  • Open Access
24 Citations
4,885 Views
16 Pages

Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential

  • Fatima Rashid,
  • Anam Javaid,
  • Mahmood-ur-Rahman,
  • Usman Ali Ashfaq,
  • Muhammad Sufyan,
  • Abdulrahman Alshammari,
  • Metab Alharbi,
  • Muhammad Atif Nisar and
  • Mohsin Khurshid

5 September 2022

Diabetes mellitus (DM) is a metabolic disease caused by improper insulin secretion leading to hyperglycemia. Syzygium cumini has excellent therapeutic properties due to its high levels of phytochemicals. The current research aimed to evaluate the ant...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
2 Citations
3,104 Views
14 Pages

5 September 2022

Aqueous root extract from Acanthopanax senticosus (ASRE) has a wide range of medicinal effects. The present work was aimed at studying the influence of sulfide, cysteine and glutathione on the antioxidant properties of ASRE and some of its selected p...

(This article belongs to the Special Issue Bioactive Compounds and Antioxidant Activity of Extracts from Different Natural Plants)
  • Article
  • Open Access
2 Citations
2,754 Views
13 Pages

A Supramolecular Approach to Antimicrobial Surfaces

  • Valentina Gazzola,
  • Pietro Grisoli,
  • Valeria Amendola,
  • Giacomo Dacarro,
  • Carlo Mangano,
  • Piersandro Pallavicini,
  • Antonio Poggi,
  • Silvia Rossi,
  • Barbara Vigani and
  • Angelo Taglietti

5 September 2022

In this paper, we report on the preparation of Imidazole-functionalized glass surfaces, demonstrating the ability of a dinuclear Cu(II) complex of a macrocyclic ligand to give a “cascade” interaction with the deprotonated forms of grafted...

(This article belongs to the Special Issue Metal Ions in Supramolecular Chemistry: A Themed Issue in Honor of Professor Luigi Fabbrizzi)
  • Article
  • Open Access
13 Citations
5,838 Views
18 Pages

Modified Protein-Water Interactions in CHARMM36m for Thermodynamics and Kinetics of Proteins in Dilute and Crowded Solutions

  • Daiki Matsubara,
  • Kento Kasahara,
  • Hisham M. Dokainish,
  • Hiraku Oshima and
  • Yuji Sugita

5 September 2022

Proper balance between protein-protein and protein-water interactions is vital for atomistic molecular dynamics (MD) simulations of globular proteins as well as intrinsically disordered proteins (IDPs). The overestimation of protein-protein interacti...

(This article belongs to the Special Issue Frontiers in Protein Folding and Related Areas – in Memory of Professor Sir Christopher M. Dobson (1949–2019))
  • Feature Paper
  • Review
  • Open Access
840 Citations
75,791 Views
33 Pages

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

  • Mamello Sekhoacha,
  • Keamogetswe Riet,
  • Paballo Motloung,
  • Lemohang Gumenku,
  • Ayodeji Adegoke and
  • Samson Mashele

5 September 2022

Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in men globally. Patients affected with prostate cancer present with either a localized or advanced disease. In this review, we aim...

(This article belongs to the Special Issue Novel Design and Synthesis of Anticancer Agents)
  • Article
  • Open Access
27 Citations
4,876 Views
16 Pages

Nano-Size Characterization and Antifungal Evaluation of Essential Oil Molecules-Loaded Nanoliposomes

  • Katya M. Aguilar-Pérez,
  • Dora I. Medina,
  • Roberto Parra-Saldívar and
  • Hafiz M. N. Iqbal

5 September 2022

Nanoliposomes, bilayer vesicles at the nanoscale, are becoming popular because of their safety, patient compliance, high entrapment efficiency, and prompt action. Several notable biological activities of natural essential oils (EOs), including fungal...

(This article belongs to the Special Issue Essential Oils II)
  • Article
  • Open Access
9 Citations
3,347 Views
14 Pages

Wistin Exerts an Anti-Inflammatory Effect via Nuclear Factor-κB and p38 Signaling Pathways in Lipopolysaccharide-Stimulated RAW264.7 Cells

  • Jangeun An,
  • Gyoungah Ryu,
  • Seong-Ah Shin,
  • Huiji Kim,
  • Mi-Jeong Ahn,
  • Jun Hyuck Lee and
  • Chang Sup Lee

5 September 2022

Inflammation is an immune response to cellular damage caused by various stimuli (internal or external) and is essential to human health. However, excessive inflammatory responses may be detrimental to the host. Considering that the existing drugs for...

(This article belongs to the Special Issue Natural Polyphenols in Human Health)
  • Article
  • Open Access
15 Citations
4,220 Views
10 Pages

5 September 2022

The Systematic Evolution of Ligands by EXponential enrichment (SELEX) is conventionally an effective method to identify aptamers, which are oligonucleotide sequences with desired properties to recognize targets specifically and sensitively. However,...

(This article belongs to the Special Issue Aptamer Generation and Bioapplication)
  • Article
  • Open Access
6 Citations
3,914 Views
10 Pages

Robust Laminated Anode with an Ultrathin Titanium Nitride Layer for High-Efficiency Top-Emitting Organic Light-Emitting Diodes

  • Jia-Heng Cai,
  • Qi-Sheng Tian,
  • Xiao-Zhao Zhu,
  • Zhi-Hao Qu,
  • Wei He,
  • Dong-Ying Zhou and
  • Liang-Sheng Liao

5 September 2022

The effective reflective anode remains a highly desirable component for the fabrication of reliable top-emitting organic light-emitting diodes (TE-OLEDs) which have the potential to be integrated with complementary metal-oxide-semiconductor (CMOS) ci...

(This article belongs to the Section Materials Chemistry)
  • Article
  • Open Access
14 Citations
3,573 Views
10 Pages

Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase

  • Mengjie Xiao,
  • Fei Cao,
  • Tao Huang,
  • Yun-Sang Tang,
  • Xin Zhao and
  • Pang-Chui Shaw

5 September 2022

Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus. To find and characterize anti-influenza virus phytochem...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
21 Citations
3,530 Views
15 Pages

Unravelling the Polytoxicology of Chlorfenapyr on Non-Target HepG2 Cells: The Involvement of Mitochondria-Mediated Programmed Cell Death and DNA Damage

  • Yuanhang Ren,
  • Xuan He,
  • Xiyue Yan,
  • Yanting Yang,
  • Qiang Li,
  • Tian Yao,
  • Lidan Lu,
  • Lianxin Peng and
  • Liang Zou

5 September 2022

Chlorfenapyr (CHL) is a type of insecticide with a wide range of insecticidal activities and unique targets. The extensive use of pesticides has caused an increase in potential risks to the environment and human health. However, the potential toxicit...

(This article belongs to the Section Chemical Biology)
  • Article
  • Open Access
47 Citations
5,372 Views
14 Pages

Chemical Markers and Pharmacological Characters of Pelargonium graveolens Essential Oil from Palestine

  • Nidal Jaradat,
  • Mohammed Hawash,
  • Mohammad Qadi,
  • Murad Abualhasan,
  • Aseel Odetallah,
  • Ghfran Qasim,
  • Reem Awayssa,
  • Amna Akkawi,
  • Ibtesam Abdullah and
  • Nawaf Al-Maharik

5 September 2022

Pelargonium graveolens leaves are widely used in traditional medicine for relieving some cardiovascular, dental, gastrointestinal, and respiratory disorders. They are also used as food and tea additives in Palestine and many other countries. Conseque...

(This article belongs to the Special Issue Essential Oils II)
  • Article
  • Open Access
9 Citations
3,567 Views
21 Pages

5 September 2022

Over the years, great attention has been paid to coumarin derivatives, a set of versatile molecules that exhibit a wide variety of biological activities and have few toxic side effects. In this study, we investigated the antidiabetic potential of 6-f...

(This article belongs to the Section Medicinal Chemistry)
  • Review
  • Open Access
42 Citations
13,540 Views
24 Pages

5 September 2022

Fatty acids (FAs) play pleiotropic roles in living organisms, acting as signaling molecules and gene regulators. They are present in plants and foods and may affect human health by food ingestion. As a consequence, analytical methods for their determ...

(This article belongs to the Special Issue Lipids–Lipolytic Enzymes–Lipid Analysis: A Themed Issue Dedicated to Prof. Edward A. Dennis for His 80th Birthday)
  • Article
  • Open Access
27 Citations
3,963 Views
13 Pages

Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition

  • Supawan Jampasri,
  • Somrudee Reabroi,
  • Duangjai Tungmunnithum,
  • Warisara Parichatikanond and
  • Darawan Pinthong

5 September 2022

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional regulator that plays a crucial role in the hypoxic response of rapidly growing tumors. Overexpression of HIF-1α has been associated with breast cancer metastasis and po...

(This article belongs to the Special Issue Flavonoids’ and Other Polyphenols’ Pharmacological Activities for Phytopharmaceutical and Medicinal Applications)
  • Article
  • Open Access
15 Citations
3,567 Views
16 Pages

5 September 2022

In this study, the ultrasonic-assisted extraction of total coumarins from Peucedanum decursivum (Miq.) Maxim (P. decursivum) via the combination of deep eutectic solvents (DESs) with cellulase pretreatment was carried out. Among the 15 kinds of DESs...

(This article belongs to the Special Issue Deep Eutectic Solvents: Properties and Applications as Green Solvents)
  • Article
  • Open Access
11 Citations
3,911 Views
20 Pages

5 September 2022

The subject of research is forty dimers formed by imidazol-2-ylidene (I) or its derivative (IR2) obtained by replacing the hydrogen atoms in both N-H bonds with larger important and popular substituents of increasing complexity (methyl = Me, iso-prop...

(This article belongs to the Collection Hydrogen Bonds)
  • Article
  • Open Access
5 Citations
5,009 Views
18 Pages

A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease

  • Alba L. Montoya,
  • Elisa G. Carvajal,
  • Uriel Ortega-Rodriguez,
  • Igor L. Estevao,
  • Roger A. Ashmus,
  • Sohan R. Jankuru,
  • Susana Portillo,
  • Cameron C. Ellis,
  • Colin D. Knight and
  • Katja Michael
  • + 11 authors

5 September 2022

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi and affects 6–7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI and Tcbat) with diverse ecoep...

(This article belongs to the Collection Advances in Glycosciences)
  • Article
  • Open Access
4 Citations
3,013 Views
9 Pages

Controlling the Treatment Time for Ideal Morphology towards Efficient Organic Solar Cells

  • Yiwen Hou,
  • Qiuning Wang,
  • Ciyuan Huang,
  • Tao Yang,
  • Shasha Shi,
  • Shangfei Yao,
  • Donglou Ren,
  • Tao Liu,
  • Guangye Zhang and
  • Bingsuo Zou

5 September 2022

In this work, we performed a systematic comparison of different duration of solvent vapor annealing (SVA) treatment upon state-of-the-art PM6:SY1 blend film, which is to say for the first time, the insufficient, appropriate, and over-treatment’s effe...

(This article belongs to the Section Materials Chemistry)
  • Article
  • Open Access
5 Citations
3,407 Views
17 Pages

Spin-Dependent First-Principles Study on Optoelectronic Properties of Neodymium Zirconates Pyrochlores Nd2Zr2O7 in Fd-3m and Pmma Phases

  • Azhar Qayyum,
  • Sikander Azam,
  • Ali H. Reshak,
  • Jehan Akbar,
  • Zeesham Abbas,
  • Haseen Ullah and
  • Muhammad M. Ramli

5 September 2022

Rare-earth zirconate pyrochlores (RE2Zr2O7) are of much fundamental and technological interest as optoelectronic, scintillator and thermal barrier coating materials. For the first time, we report the detailed optoelectronic properties of rare-earth z...

  • Review
  • Open Access
24 Citations
6,423 Views
23 Pages

Computer-Aided Drug Design Boosts RAS Inhibitor Discovery

  • Ge Wang,
  • Yuhao Bai,
  • Jiarui Cui,
  • Zirui Zong,
  • Yuan Gao and
  • Zhen Zheng

5 September 2022

The Rat Sarcoma (RAS) family (NRAS, HRAS, and KRAS) is endowed with GTPase activity to regulate various signaling pathways in ubiquitous animal cells. As proto-oncogenes, RAS mutations can maintain activation, leading to the growth and proliferation...

(This article belongs to the Special Issue Computational Strategy for Drug Design)
  • Review
  • Open Access
85 Citations
11,544 Views
41 Pages

A Review of Stimuli-Responsive Smart Materials for Wearable Technology in Healthcare: Retrospective, Perspective, and Prospective

  • Valentina Trovato,
  • Silvia Sfameni,
  • Giulia Rando,
  • Giuseppe Rosace,
  • Sebania Libertino,
  • Ada Ferri and
  • Maria Rosaria Plutino

5 September 2022

In recent years thanks to the Internet of Things (IoT), the demand for the development of miniaturized and wearable sensors has skyrocketed. Among them, novel sensors for wearable medical devices are mostly needed. The aim of this review is to summar...

(This article belongs to the Special Issue Materials for Healthcare)
  • Article
  • Open Access
1 Citations
2,838 Views
15 Pages

5 September 2022

The photosystem II (PSII) reaction centre is the critical supramolecular pigment–protein complex in the chloroplast which catalyses the light-induced transfer of electrons from water to plastoquinone. Structural studies have demonstrated the ex...

(This article belongs to the Special Issue Photosystem II Photochemistry in Biotic and Abiotic Stress)
  • Communication
  • Open Access
5 Citations
5,160 Views
11 Pages

Ortho-Phosphinoarenesulfonamide-Mediated Staudinger Reduction of Aryl and Alkyl Azides

  • Xingzhuo Li,
  • Zhenguo Wang,
  • Wenjun Luo,
  • Zixu Wang,
  • Keshu Yin and
  • Le Li

5 September 2022

Conventional Staudinger reductions of organic azides are sluggish with aryl or bulky aliphatic azides. In addition, Staudinger reduction usually requires a large excess of water to promote the decomposition of the aza-ylide intermediate into phosphin...

(This article belongs to the Special Issue Modern Organophosphorus Chemistry)
  • Article
  • Open Access
11 Citations
4,883 Views
15 Pages

Fast and Sensitive HPLC-ESI-MS/MS Method for Etoricoxib Quantification in Human Plasma and Application to Bioequivalence Study

  • Gabriel Onn Kit Loh,
  • Emily Yii Ling Wong,
  • Yvonne Tze Fung Tan,
  • Siew Chyee Heng,
  • Mardiana Saaid,
  • Kit Yee Cheah,
  • Nurul Diyana Mohd Sali,
  • Nair Damenthi,
  • Sharon Shi Min Ng and
  • Kok Khiang Peh
  • + 1 author

4 September 2022

Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. The objective of the current study was to develop a sensitive, fast and high-throughput HPLC-ESI-MS/MS method to measure etoricoxib levels in human plas...

  • Article
  • Open Access
8 Citations
3,536 Views
16 Pages

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

  • Houda Zentar,
  • Fatin Jannus,
  • Marta Medina-O’Donnell,
  • José A. Lupiáñez,
  • José Justicia,
  • Ramón Alvarez-Manzaneda,
  • Fernando J. Reyes-Zurita,
  • Enrique Alvarez-Manzaneda and
  • Rachid Chahboun

4 September 2022

A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopol...

(This article belongs to the Special Issue Natural and Synthetic Anti-cancer Drug Discovery)
  • Article
  • Open Access
6 Citations
3,118 Views
14 Pages

Optimization of 5-CQA Extraction Conditions from Green Coffee By-Product (Coffea arabica) Using a Response-Surface Design and the Study of Its Extraction Kinetics

  • Miriam Granados-Vallejo,
  • Enrique Arriola-Guevara,
  • Rosa Isela Corona-González,
  • David Antonio Flores-Méndez,
  • José Daniel Padilla-de la Rosa,
  • Hugo Esquivel-Solis,
  • Carlos Pelayo-Ortiz and
  • Guadalupe María Guatemala-Morales

4 September 2022

To take advantage of the residues generated in the production of products from green coffee and due to the special interest in the compounds contained in the bean, a by-product obtained after the extraction of the oil was studied. The physical charac...

(This article belongs to the Special Issue Antioxidants from Natural Sources: Separation and Characterization Ⅱ)
  • Review
  • Open Access
12 Citations
4,349 Views
17 Pages

4 September 2022

Besides their extremely useful properties as solvent, ionic liquids (ILs) are now considered to be highly instructive tools for enhancing the rates of chemical reactions. The ionic nature of the IL anion and cation seems to be the origin of this fasc...

(This article belongs to the Special Issue Feature Papers in Applied Chemistry)
  • Article
  • Open Access
14 Citations
3,564 Views
7 Pages

The Luteolinidin and Petunidin 3-O-Glucoside: A Competitive Inhibitor of Tyrosinase

  • Seo Young Yang,
  • Jang Hoon Kim,
  • Xiangdong Su and
  • Jeong Ah Kim

4 September 2022

The enzyme tyrosinase plays a key role in the early stages of melanin biosynthesis. This study evaluated the inhibitory activity of anthocyanidin (1) and anthocyanins (26) on the catalytic reaction. Of the six derivatives examined, 13 s...

(This article belongs to the Special Issue Key Role of Natural Bioactive Compounds in Health and Diseases)
  • Article
  • Open Access
2 Citations
2,577 Views
9 Pages

Daphnane-Type Diterpenes from Stelleropsis tianschanica and Their Antitumor Activity

  • Xiaoyan He,
  • Xiatiguli Abulizi,
  • Xiaowan Li,
  • Guoxu Ma,
  • Zhaocui Sun,
  • Hongyan Wei,
  • Xudong Xu,
  • Leiling Shi and
  • Jing Zhang

4 September 2022

Four new daphnane-type diterpenes named tianchaterpenes C-F (14) and six known ones were isolated from Stelleropsis tianschanica. Their structures were elucidated based on chemical and spectral analyses. The comparisons of calculated and exper...

(This article belongs to the Special Issue Trends in Biologically Active Compounds for Biomedicines and Natural Products)
  • Article
  • Open Access
25 Citations
6,251 Views
17 Pages

4 September 2022

When peanuts germinate, bioactive compounds such as resveratrol (RES), γ-aminobutyric acid (GABA), isoflavones, and polyphenol compounds are generated. Peanut kernels were germinated in the dark for two days, and stimuli including soaking liqui...

(This article belongs to the Special Issue Bioactive Compounds and Antioxidant Activity of Extracts from Different Natural Plants)
  • Article
  • Open Access
25 Citations
3,600 Views
13 Pages

Environmentally Safe Photodynamic Control of Aedes aegypti Using Sunlight-Activated Synthetic Curcumin: Photodegradation, Aquatic Ecotoxicity, and Field Trial

  • Alessandra R. Lima,
  • Cicera M. Silva,
  • Lucas M. da Silva,
  • Amilcar Machulek,
  • Antônio P. de Souza,
  • Kleber T. de Oliveira,
  • Larissa M. Souza,
  • Natalia M. Inada,
  • Vanderlei S. Bagnato and
  • Anderson R. L. Caires
  • + 1 author

4 September 2022

This study reports curcumin as an efficient photolarvicide against Aedes aegypti larvae under natural light illumination. Larval mortality and pupal formation were monitored daily for 21 days under simulated field conditions. In a sucrose-containing...

(This article belongs to the Section Applied Chemistry)
  • Article
  • Open Access
10 Citations
2,887 Views
13 Pages

4 September 2022

Sceptridium ternatum is a herbaceous plant with significant potential for pharmaceutical and cosmetic applications. In this study, we established a spectrum-effect relationship-based strategy to investigate the bioactive basis and tissue distribution...

(This article belongs to the Special Issue Bioactive Flavonoids and Xanthones: From Bench to Industry. Pharmaceutical, Cosmetic and Industrial Applications)
  • Article
  • Open Access
13 Citations
3,420 Views
15 Pages

4 September 2022

An ultrasound-assisted, one-pot cloud point extraction was developed for the determination of iron in vegetable samples by UV-Visible spectrophotometry. This method was based on the complexation of iron with an environmentally-friendly natural chelat...

(This article belongs to the Section Analytical Chemistry)
  • Article
  • Open Access
4 Citations
3,647 Views
25 Pages

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces

  • Roman Major,
  • Grażyna Wilczek,
  • Justyna Więcek,
  • Maciej Gawlikowski,
  • Hanna Plutecka,
  • Katarzyna Kasperkiewicz,
  • Marcin Kot,
  • Małgorzata Pomorska,
  • Roman Ostrowski and
  • Magdalena Kopernik

4 September 2022

The aim of this study was to minimize the risk of life-threatening thromboembolism in the ventricle through the use of a new biomimetic heart valve based on metal–polymer composites. Finite volume element simulations of blood adhesion to the ma...

  • Article
  • Open Access
17 Citations
3,806 Views
13 Pages

Optimization of Flavonoid Extraction from Salix babylonica L. Buds, and the Antioxidant and Antibacterial Activities of the Extract

  • Peng Zhang,
  • Yuwen Song,
  • Hongling Wang,
  • Yujie Fu,
  • Yingying Zhang and
  • Korotkova Irina Pavlovna

3 September 2022

The present study was designed to evaluate the chemical extraction, chemical composition, and antioxidant and antibacterial properties of the total flavonoids in Willow Buds (TFW). We investigated the optimal extraction of TFW using response surface...

(This article belongs to the Special Issue Advances in Natural Products and Their Biological Activities)
  • Article
  • Open Access
3 Citations
2,883 Views
15 Pages

Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules

  • Vladislav V. Nikol’skiy,
  • Mikhail E. Minyaev,
  • Maxim A. Bastrakov and
  • Alexey M. Starosotnikov

3 September 2022

A number of new 2-methyl- and 2-arylvinyl-3-nitropyridines were synthesized and their reactions with thiols were studied. It was found that 3-NO2 tends to be selectively substituted under the action of sulfur nucleophiles in the presence of another n...

(This article belongs to the Special Issue Recent Developments in the Synthesis and Functionalization of Nitrogen Heterocycles)
  • Article
  • Open Access
3 Citations
3,475 Views
13 Pages

Metal-Free Phosphination and Continued Functionalization of Pyridine: A Theoretical Study

  • Pan Du,
  • Yuhao Yin,
  • Dai Shi,
  • Kexin Mao,
  • Qianyuan Yu and
  • Jiyang Zhao

3 September 2022

This study investigates the mechanism of metal-free pyridine phosphination with P(OEt)3, PPh3, and PAr2CF3 using density functional theory calculations. The results show that the reaction mechanism and rate-determining step vary depending on the phos...

(This article belongs to the Special Issue Theoretical Investigations of Reaction Mechanisms II)
  • Communication
  • Open Access
20 Citations
3,476 Views
12 Pages

A Polyclonal Selex Aptamer Library Directly Allows Specific Labelling of the Human Gut Bacterium Blautia producta without Isolating Individual Aptamers

  • Hu Xing,
  • Yiting Zhang,
  • Markus Krämer,
  • Ann-Kathrin Kissmann,
  • Marius Henkel,
  • Tanja Weil,
  • Uwe Knippschild and
  • Frank Rosenau

3 September 2022

Recent studies have demonstrated that changes in the abundance of the intestinal bacterium Blautia producta, a potential probiotic, are closely associated with the development of various diseases such as obesity, diabetes, some neurodegenerative dise...

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Molecules - ISSN 1420-3049