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Molecules, Volume 26, Issue 9

May-1 2021 - 432 articles

Cover Story: Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Temozolomide is the only drug approved by the FDA. In the last decade, nearly fifty compounds with inhibitory activity on the proliferation of several glioma cells were isolated from anemone, seaweeds, invertebrates, sponges, corals, fungi, and crustaceous species. From these structurally diverse compounds, ten may be able to cross BBB, i.e., the pyrazolidene 5, isolated from an anemone, the most potent compound (IC50 = 0.5-3.0µM), followed by the plakortide 29 (IC50 = 4.0µM) and the polyketide 38 (IC50 = 4.1µM), both isolated from sponges, and by the polyketide 40 (IC50 = 5.1–6.9µM), isolated from corals. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment. View this paper.
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Articles (432)

  • Review
  • Open Access
16 Citations
4,630 Views
14 Pages

The Potential Role of Polyphenols in Modulating Mitochondrial Bioenergetics within the Skeletal Muscle: A Systematic Review of Preclinical Models

  • Sinenhlanhla X. H. Mthembu,
  • Phiwayinkosi V. Dludla,
  • Khanyisani Ziqubu,
  • Tawanda M. Nyambuya,
  • Abidemi P. Kappo,
  • Evelyn Madoroba,
  • Thembeka A. Nyawo,
  • Bongani B. Nkambule,
  • Sonia Silvestri and
  • Christo J. F. Muller
  • + 1 author

Polyphenols are naturally derived compounds that are increasingly being explored for their various health benefits. In fact, foods that are rich in polyphenols have become an attractive source of nutrition and a potential therapeutic strategy to alle...

  • Article
  • Open Access
8 Citations
2,845 Views
19 Pages

The synergism/inhibition level, solubilization sites and the total solubility (St) of co-solubilization systems of phenanthrene, anthracene and pyrene in Tween 80 and sodium dodecyl sulfate (SDS) are studied by 1H-NMR, 2D nuclear overhauser effect sp...

  • Feature Paper
  • Article
  • Open Access
9 Citations
3,012 Views
19 Pages

Ferro- and Antiferromagnetic Interactions in Oxalato-Centered Inverse Hexanuclear and Chain Copper(II) Complexes with Pyrazole Derivatives

  • Isabel Castro,
  • M. Luisa Calatayud,
  • Marta Orts-Arroyo,
  • Nicolás Moliner,
  • Nadia Marino,
  • Francesc Lloret,
  • Rafael Ruiz-García,
  • Giovanni De Munno and
  • Miguel Julve

Two novel copper(II) complexes of formulas {[Cu(4-Hmpz)4][Cu(4-Hmpz)2(µ3-ox-κ2O1,O2:κO2′:κO1′)(ClO4)2]}n (1) and {[Cu(3,4,5-Htmpz)4]2[Cu(3,4,5-Htmpz)2(µ3-ox-κ2O1,O2:κO2′:κO1′)(H2O)(ClO4)]2[Cu2(3,4,5-Htmpz)4(µ-ox-κ2O1,O2:κ2O2′,O1′)]}(ClO4)4·6H2O (2) h...

  • Review
  • Open Access
33 Citations
6,160 Views
26 Pages

Chemistry and Pharmacology of Cyperaceae Stilbenoids: A Review

  • Csilla Zsuzsanna Dávid,
  • Judit Hohmann and
  • Andrea Vasas

Cyperaceae is a cosmopolitan plant family with approx. 5000 species distributed worldwide. Several members of this family are used in traditional medicines for the treatment of different diseases. In the last few decades, constituents with great chem...

  • Article
  • Open Access
14 Citations
3,047 Views
9 Pages

In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae)

  • Jean Claude Didelot Tomani,
  • Olivier Bonnet,
  • Alain Nyirimigabo,
  • William Deschamps,
  • Alembert Tiabou Tchinda,
  • Olivia Jansen,
  • Allison Ledoux,
  • Marie Jeanne Mukazayire,
  • Luc Vanhamme and
  • Michel Frédérich
  • + 2 authors

Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in the top three infectious diseases in the world. Plants of the Eriosema genus have been reported to be used for the treatment of this disease, but scientific evidence...

  • Review
  • Open Access
50 Citations
6,025 Views
19 Pages

Graphene Oxide-Based Stimuli-Responsive Platforms for Biomedical Applications

  • Tejal V. Patil,
  • Dinesh K. Patel,
  • Sayan Deb Dutta,
  • Keya Ganguly and
  • Ki-Taek Lim

Graphene is a two-dimensional sp2 hybridized carbon material that has attracted tremendous attention for its stimuli-responsive applications, owing to its high surface area and excellent electrical, optical, thermal, and mechanical properties. The ph...

  • Communication
  • Open Access
3 Citations
2,758 Views
8 Pages

Semisynthesis of Selenoauraptene

  • Serena Fiorito,
  • Francesco Epifano,
  • Lorenzo Marchetti and
  • Salvatore Genovese

Selenium-containing compounds are gaining more and more interest due to their valuable and promising pharmacological properties, mainly as anticancer and antioxidant agents. Ebselen, the up to now only approved drugs, is well known to possess very go...

  • Review
  • Open Access
20 Citations
5,977 Views
16 Pages

The synthesis of organometallic compounds with potential pharmacological activity has attracted the attention of many research groups, aiming to take advantage of aspects that the presence of the metal-carbon bond can bring to the design of new pharm...

  • Review
  • Open Access
133 Citations
10,141 Views
16 Pages

Current Trends in the Application of Nanomaterials for the Removal of Pollutants from Industrial Wastewater Treatment—A Review

  • Geetha Palani,
  • A. Arputhalatha,
  • Karthik Kannan,
  • Sivarama Krishna Lakkaboyana,
  • Marlia M. Hanafiah,
  • Vinay Kumar and
  • Ravi Kumar Marella

In the recent decades, development of new and innovative technology resulted in a very high amount of effluents. Industrial wastewaters originating from various industries contribute as a major source of water pollution. The pollutants in the wastewa...

  • Article
  • Open Access
18 Citations
3,467 Views
14 Pages

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

  • Mariia M. Efremova,
  • Anastasia I. Govdi,
  • Valeria V. Frolova,
  • Andrey M. Rumyantsev and
  • Irina A. Balova

Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5-aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their opt...

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Molecules - ISSN 1420-3049