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Review

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

1
UCIBIO, REQUIMTE, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
2
Laboratory of Pharmaceutical Technology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
3
Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
4
Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões Avenida General Norton de Matos P, 4450-208 Matosinhos, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Changsheng Zhang
Molecules 2021, 26(9), 2707; https://doi.org/10.3390/molecules26092707
Received: 16 April 2021 / Revised: 3 May 2021 / Accepted: 3 May 2021 / Published: 5 May 2021
Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment. View Full-Text
Keywords: glioma; marine compound; drug discovery glioma; marine compound; drug discovery
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MDPI and ACS Style

Alves, A.; Costa, P.; Pinto, M.; Ferreira, D.; Correia-da-Silva, M. Small Molecules of Marine Origin as Potential Anti-Glioma Agents. Molecules 2021, 26, 2707. https://doi.org/10.3390/molecules26092707

AMA Style

Alves A, Costa P, Pinto M, Ferreira D, Correia-da-Silva M. Small Molecules of Marine Origin as Potential Anti-Glioma Agents. Molecules. 2021; 26(9):2707. https://doi.org/10.3390/molecules26092707

Chicago/Turabian Style

Alves, Ana, Paulo Costa, Madalena Pinto, Domingos Ferreira, and Marta Correia-da-Silva. 2021. "Small Molecules of Marine Origin as Potential Anti-Glioma Agents" Molecules 26, no. 9: 2707. https://doi.org/10.3390/molecules26092707

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