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Molecules, Volume 26, Issue 12

June-2 2021 - 296 articles

Cover Story: In cancer cells, the EphA2 receptor promotes cell migration and increases metastases. These pro-oncogenic signaling events can be reversed by binding the receptor with its dimeric ligands that cause EphA2 degradation. We propose that novel synthetic EphA2 ligands can be engineered by preparing proper biotinylated agonistic peptides, which are then conjugated with streptavidin. We report that the resulting complex presented a markedly increased ability to induce EphA2 receptor degradation in cancer cells. Moreover, we demonstrated that a fluorescently labeled EphA2-targeting–streptavidin complex is localized at the respective tumor sites in orthotopic models of breast and pancreatic cancers, suggesting possible developments of the system for diagnostic or therapeutic applications. View this paper.
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Articles (296)

  • Article
  • Open Access
10 Citations
3,197 Views
17 Pages

The Reaction of Hydrogen Halides with Tetrahydroborate Anion and Hexahydro-closo-hexaborate Dianion

  • Igor E. Golub,
  • Oleg A. Filippov,
  • Natalia V. Belkova,
  • Lina M. Epstein and
  • Elena S. Shubina

20 June 2021

The mechanism of the consecutive halogenation of the tetrahydroborate anion [BH4]− by hydrogen halides (HX, X = F, Cl, Br) and hexahydro-closo-hexaborate dianion [B6H6]2− by HCl via electrophile-induced nucleophilic substitution (EINS) was establishe...

  • Review
  • Open Access
107 Citations
12,680 Views
20 Pages

Immunomodulatory Effects of Green Tea Polyphenols

  • Shuzhen Wang,
  • Zhiliang Li,
  • Yuting Ma,
  • Yan Liu,
  • Chi-Chen Lin,
  • Shiming Li,
  • Jianfeng Zhan and
  • Chi-Tang Ho

20 June 2021

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action....

  • Communication
  • Open Access
8 Citations
3,209 Views
7 Pages

20 June 2021

A biosensing membrane base on ferulic acid and glucose oxidase is synthesized onto a carbon paste electrode by electropolymerization via cyclic voltammetry in aqueous media at neutral pH at a single step. The developed biosensors exhibit a linear res...

  • Article
  • Open Access
2,765 Views
16 Pages

20 June 2021

The field of chemical and physical transformations induced by ultrasonic waves has shown steady progress during the past decades. There is a solid core of established results and some topics that are not thoroughly developed. The effect of varying ul...

  • Article
  • Open Access
11 Citations
3,726 Views
11 Pages

Imaging and SERS Study of the Au Nanoparticles Interaction with HPV and Carcinogenic Cervical Tissues

  • Andrea Ceja-Fdez,
  • Ramon Carriles,
  • Ana Lilia González-Yebra,
  • Juan Vivero-Escoto,
  • Elder de la Rosa and
  • Tzarara López-Luke

20 June 2021

In this work, gold NPs were prepared by the Turkevich method, and their interaction with HPV and cancerous cervical tissues were studied by scanning electron microscopy, energy-dispersive x-ray spectroscopy, confocal and multiphoton microscopy and SE...

  • Article
  • Open Access
29 Citations
5,837 Views
13 Pages

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

  • Simona S. Ghanem,
  • Hend S. Fayed,
  • Qi Zhu,
  • Jia-Hong Lu,
  • Nishant N. Vaikath,
  • Janarthanan Ponraj,
  • Said Mansour and
  • Omar M. A. El-Agnaf

19 June 2021

The accumulation and aggregation of α-synuclein (α-syn) is the main pathologic event in Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-Syn-seeded fibril formation and its induced toxicity occupy a major role in PD...

  • Review
  • Open Access
32 Citations
4,091 Views
24 Pages

Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness

  • Joana Moreira,
  • Joana Almeida,
  • Lucília Saraiva,
  • Honorina Cidade and
  • Madalena Pinto

19 June 2021

The p53 protein is one of the most important tumor suppressors that are frequently inactivated in cancer cells. This inactivation occurs either because the TP53 gene is mutated or deleted, or due to the p53 protein inhibition by endogenous negative r...

  • Article
  • Open Access
49 Citations
4,132 Views
18 Pages

Development and Characterization of Novel Composite Films Based on Soy Protein Isolate and Oilseed Flours

  • Magdalena Mikus,
  • Sabina Galus,
  • Agnieszka Ciurzyńska and
  • Monika Janowicz

19 June 2021

The possibility of using oilseed flours as a waste source for film-forming materials with a combination of soy protein isolate in preparation of edible films was evaluated. Physical, mechanical and barrier properties were determined as a function of...

  • Article
  • Open Access
10 Citations
3,508 Views
11 Pages

Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries

  • Sakkarapalayam M. Mahalingam,
  • Karson S. Putt,
  • Madduri Srinivasarao and
  • Philip S. Low

19 June 2021

The inadvertent severing of a ureter during surgery occurs in as many as 4.5% of colorectal surgeries. To help prevent this issue, several near-infrared (NIR) dyes have been developed to assist surgeons with identifying ureter location. However, the...

  • Article
  • Open Access
18 Citations
3,594 Views
20 Pages

Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach

  • Muddaser Shah,
  • Waheed Murad,
  • Najeeb Ur Rehman,
  • Sobia Ahsan Halim,
  • Manzoor Ahmed,
  • Hazir Rehman,
  • Muhammed Zahoor,
  • Sidra Mubin,
  • Ajmal Khan and
  • Mohamed A. Nassan
  • + 2 authors

19 June 2021

In the current study, in vitro antimicrobial and antioxidant activities and in vivo anti-inflammatory and analgesic activities of Scutellaria edelbergii Rech. f. (crude extract and subfractions, i.e., n-hexane, ethyl acetate (EtOAc), chloroform, n-bu...

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Molecules - ISSN 1420-3049