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Molecules, Volume 26, Issue 12

2021 June-2 - 296 articles

Cover Story: In cancer cells, the EphA2 receptor promotes cell migration and increases metastases. These pro-oncogenic signaling events can be reversed by binding the receptor with its dimeric ligands that cause EphA2 degradation. We propose that novel synthetic EphA2 ligands can be engineered by preparing proper biotinylated agonistic peptides, which are then conjugated with streptavidin. We report that the resulting complex presented a markedly increased ability to induce EphA2 receptor degradation in cancer cells. Moreover, we demonstrated that a fluorescently labeled EphA2-targeting–streptavidin complex is localized at the respective tumor sites in orthotopic models of breast and pancreatic cancers, suggesting possible developments of the system for diagnostic or therapeutic applications. View this paper.
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Articles (296)

  • Article
  • Open Access
7 Citations
3,770 Views
15 Pages

21 June 2021

Studies have reported that cholesterol, a molecule found mainly in animals, is also present in some plants and algae. This study aimed to determine whether cholesterol exists in three dehydrated algae species, namely, Pyropia tenera, Saccharina japon...

  • Article
  • Open Access
10 Citations
4,371 Views
15 Pages

Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq.

  • Andrés Oliveros-Díaz,
  • Jesús Olivero-Verbel,
  • Yina Pájaro-González and
  • Fredyc Díaz-Castillo

21 June 2021

Alkaloids are a group of secondary metabolites that have been widely studied for the discovery of new drugs due to their properties on the central nervous system and their anti-inflammatory, antioxidant and anti-cancer activities. Molecular docking w...

  • Article
  • Open Access
18 Citations
4,843 Views
12 Pages

High Pressure Processing Impact on Alternariol and Aflatoxins of Grape Juice and Fruit Juice-Milk Based Beverages

  • Noelia Pallarés,
  • Albert Sebastià,
  • Vicente Martínez-Lucas,
  • Mario González-Angulo,
  • Francisco J. Barba,
  • Houda Berrada and
  • Emilia Ferrer

21 June 2021

High-pressure processing (HPP) has emerged over the last 2 decades as a good alternative to traditional thermal treatment for food safety and shelf-life extension, supplying foods with similar characteristics to those of fresh products. Currently, HP...

  • Review
  • Open Access
41 Citations
6,848 Views
27 Pages

21 June 2021

Soap applications for cleaning and personal care have been used for more than 4000 years, dating back to the pharaonic period, and have widely proliferated with the appearance of synthetic surfactants a century ago. Synthetic surfactants used to make...

  • Article
  • Open Access
67 Citations
5,769 Views
27 Pages

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

  • Ayman Abo Elmaaty,
  • Mohammed I. A. Hamed,
  • Muhammad I. Ismail,
  • Eslam B. Elkaeed,
  • Hamada S. Abulkhair,
  • Muhammad Khattab and
  • Ahmed A. Al-Karmalawy

21 June 2021

The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, repurposing of FDA-approved drugs such as NSAIDs against COVID-19 can provide th...

  • Review
  • Open Access
26 Citations
8,741 Views
18 Pages

21 June 2021

In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products conta...

  • Article
  • Open Access
10 Citations
3,574 Views
10 Pages

The Additive Influence of Propane-1,2-Diol on SDS Micellar Structure and Properties

  • Martina Gudelj,
  • Paola Šurina,
  • Lucija Jurko,
  • Ante Prkić and
  • Perica Bošković

21 June 2021

Micellar systems are colloids with significant properties for pharmaceutical and food applications. They can be used to formulate thermodynamically stable mixtures to solubilize hydrophobic food-related substances. Furthermore, micellar formation is...

  • Article
  • Open Access
9 Citations
2,589 Views
14 Pages

21 June 2021

This work addressed the preservative behaviour of different icing media containing extracts from the alga Bifurcaria bifurcata. A comparative study of the antimicrobial and antioxidant effects of aqueous and ethanolic extracts of this macroalga was c...

  • Article
  • Open Access
8 Citations
4,018 Views
15 Pages

Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study

  • Nourhan Hisham Shady,
  • Alaa M. Hayallah,
  • Mamdouh F. A. Mohamed,
  • Mohammed M. Ghoneim,
  • Garri Chilingaryan,
  • Mohammad M. Al-Sanea,
  • Mostafa A. Fouad,
  • Mohamed Salah Kamel and
  • Usama Ramadan Abdelmohsen

21 June 2021

Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from Amphimedon sp. via a molecular dockin...

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Molecules - ISSN 1420-3049