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Molecules, Volume 26, Issue 12

2021 June-2 - 296 articles

Cover Story: In cancer cells, the EphA2 receptor promotes cell migration and increases metastases. These pro-oncogenic signaling events can be reversed by binding the receptor with its dimeric ligands that cause EphA2 degradation. We propose that novel synthetic EphA2 ligands can be engineered by preparing proper biotinylated agonistic peptides, which are then conjugated with streptavidin. We report that the resulting complex presented a markedly increased ability to induce EphA2 receptor degradation in cancer cells. Moreover, we demonstrated that a fluorescently labeled EphA2-targeting–streptavidin complex is localized at the respective tumor sites in orthotopic models of breast and pancreatic cancers, suggesting possible developments of the system for diagnostic or therapeutic applications. View this paper.
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Articles (296)

  • Article
  • Open Access
13 Citations
3,408 Views
11 Pages

The Fumarprotocetraric Acid Inhibits Tau Covalently, Avoiding Cytotoxicity of Aggregates in Cells

  • Camila González,
  • Constanza Cartagena,
  • Leonardo Caballero,
  • Francisco Melo,
  • Carlos Areche and
  • Alberto Cornejo

21 June 2021

Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory response. Moreover, tau inhibitors...

  • Article
  • Open Access
12 Citations
5,512 Views
13 Pages

21 June 2021

Polyscias fruticosa (L.) leaves contain significant bioactive compounds with high antioxidant activity such as chlorophylls, total polyphenols, etc. but these have still been underutilized. In this study, the kinetics of chlorophyll and antioxidant a...

  • Review
  • Open Access
14 Citations
6,180 Views
21 Pages

Nutraceuticals and Enteric Glial Cells

  • Laura López-Gómez,
  • Agata Szymaszkiewicz,
  • Marta Zielińska and
  • Raquel Abalo

21 June 2021

Until recently, glia were considered to be a structural support for neurons, however further investigations showed that glial cells are equally as important as neurons. Among many different types of glia, enteric glial cells (EGCs) found in the gastr...

  • Article
  • Open Access
20 Citations
4,863 Views
12 Pages

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

  • Ning Liang,
  • Yuk-Man Li,
  • Zouyan He,
  • Wangjun Hao,
  • Yimin Zhao,
  • Jianhui Liu,
  • Hanyue Zhu,
  • Erika Kwek,
  • Ka-Ying Ma and
  • Zhen-Yu Chen
  • + 1 author

21 June 2021

Rutin (R) and quercetin (Q) are two widespread dietary flavonoids. Previous studies regarding the plasma cholesterol-lowering activity of R and Q generated inconsistent results. The present study was therefore carried out to investigate the effects o...

  • Article
  • Open Access
7 Citations
3,753 Views
15 Pages

21 June 2021

Studies have reported that cholesterol, a molecule found mainly in animals, is also present in some plants and algae. This study aimed to determine whether cholesterol exists in three dehydrated algae species, namely, Pyropia tenera, Saccharina japon...

  • Article
  • Open Access
10 Citations
4,357 Views
15 Pages

Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq.

  • Andrés Oliveros-Díaz,
  • Jesús Olivero-Verbel,
  • Yina Pájaro-González and
  • Fredyc Díaz-Castillo

21 June 2021

Alkaloids are a group of secondary metabolites that have been widely studied for the discovery of new drugs due to their properties on the central nervous system and their anti-inflammatory, antioxidant and anti-cancer activities. Molecular docking w...

  • Article
  • Open Access
17 Citations
4,815 Views
12 Pages

High Pressure Processing Impact on Alternariol and Aflatoxins of Grape Juice and Fruit Juice-Milk Based Beverages

  • Noelia Pallarés,
  • Albert Sebastià,
  • Vicente Martínez-Lucas,
  • Mario González-Angulo,
  • Francisco J. Barba,
  • Houda Berrada and
  • Emilia Ferrer

21 June 2021

High-pressure processing (HPP) has emerged over the last 2 decades as a good alternative to traditional thermal treatment for food safety and shelf-life extension, supplying foods with similar characteristics to those of fresh products. Currently, HP...

  • Review
  • Open Access
41 Citations
6,807 Views
27 Pages

21 June 2021

Soap applications for cleaning and personal care have been used for more than 4000 years, dating back to the pharaonic period, and have widely proliferated with the appearance of synthetic surfactants a century ago. Synthetic surfactants used to make...

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Molecules - ISSN 1420-3049