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Molecules, Volume 26, Issue 12

2021 June-2 - 296 articles

Cover Story: In cancer cells, the EphA2 receptor promotes cell migration and increases metastases. These pro-oncogenic signaling events can be reversed by binding the receptor with its dimeric ligands that cause EphA2 degradation. We propose that novel synthetic EphA2 ligands can be engineered by preparing proper biotinylated agonistic peptides, which are then conjugated with streptavidin. We report that the resulting complex presented a markedly increased ability to induce EphA2 receptor degradation in cancer cells. Moreover, we demonstrated that a fluorescently labeled EphA2-targeting–streptavidin complex is localized at the respective tumor sites in orthotopic models of breast and pancreatic cancers, suggesting possible developments of the system for diagnostic or therapeutic applications. View this paper.
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Articles (296)

  • Article
  • Open Access
66 Citations
5,757 Views
27 Pages

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

  • Ayman Abo Elmaaty,
  • Mohammed I. A. Hamed,
  • Muhammad I. Ismail,
  • Eslam B. Elkaeed,
  • Hamada S. Abulkhair,
  • Muhammad Khattab and
  • Ahmed A. Al-Karmalawy

21 June 2021

The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, repurposing of FDA-approved drugs such as NSAIDs against COVID-19 can provide th...

  • Review
  • Open Access
26 Citations
8,709 Views
18 Pages

21 June 2021

In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products conta...

  • Article
  • Open Access
10 Citations
3,561 Views
10 Pages

The Additive Influence of Propane-1,2-Diol on SDS Micellar Structure and Properties

  • Martina Gudelj,
  • Paola Šurina,
  • Lucija Jurko,
  • Ante Prkić and
  • Perica Bošković

21 June 2021

Micellar systems are colloids with significant properties for pharmaceutical and food applications. They can be used to formulate thermodynamically stable mixtures to solubilize hydrophobic food-related substances. Furthermore, micellar formation is...

  • Article
  • Open Access
9 Citations
2,575 Views
14 Pages

21 June 2021

This work addressed the preservative behaviour of different icing media containing extracts from the alga Bifurcaria bifurcata. A comparative study of the antimicrobial and antioxidant effects of aqueous and ethanolic extracts of this macroalga was c...

  • Article
  • Open Access
8 Citations
4,007 Views
15 Pages

Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study

  • Nourhan Hisham Shady,
  • Alaa M. Hayallah,
  • Mamdouh F. A. Mohamed,
  • Mohammed M. Ghoneim,
  • Garri Chilingaryan,
  • Mohammad M. Al-Sanea,
  • Mostafa A. Fouad,
  • Mohamed Salah Kamel and
  • Usama Ramadan Abdelmohsen

21 June 2021

Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from Amphimedon sp. via a molecular dockin...

  • Article
  • Open Access
6 Citations
4,264 Views
22 Pages

21 June 2021

Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath samp...

  • Article
  • Open Access
6 Citations
2,559 Views
13 Pages

Hydration Kinetics for Alkaline Activation of Slag from Color Variation Data

  • Zhaoyang Ding,
  • Jinghai Zhou,
  • Qun Su,
  • Hong Sun,
  • Yichao Zhang,
  • Qing Wang,
  • Hongguang Bian and
  • Fengxin Dong

21 June 2021

In this study, we explore a new method based on color variation data to derive the kinetics of the entire process of the hydration of alkali-activated slag (AAS). Using this image analysis technique, we can monitor the induction period that cannot be...

  • Article
  • Open Access
58 Citations
9,216 Views
14 Pages

Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via a Three-Component Biginelli Reaction

  • Giovanna Bosica,
  • Fiona Cachia,
  • Riccardo De Nittis and
  • Nicole Mariotti

20 June 2021

Multicomponent reactions are considered to be of increasing importance as time progresses due to the economic and environmental advantages such strategies entail. The three-component Biginelli reaction involves the combination of an aldehyde, a β-ket...

  • Article
  • Open Access
10 Citations
3,370 Views
17 Pages

The Reaction of Hydrogen Halides with Tetrahydroborate Anion and Hexahydro-closo-hexaborate Dianion

  • Igor E. Golub,
  • Oleg A. Filippov,
  • Natalia V. Belkova,
  • Lina M. Epstein and
  • Elena S. Shubina

20 June 2021

The mechanism of the consecutive halogenation of the tetrahydroborate anion [BH4]− by hydrogen halides (HX, X = F, Cl, Br) and hexahydro-closo-hexaborate dianion [B6H6]2− by HCl via electrophile-induced nucleophilic substitution (EINS) was establishe...

  • Communication
  • Open Access
8 Citations
3,303 Views
7 Pages

20 June 2021

A biosensing membrane base on ferulic acid and glucose oxidase is synthesized onto a carbon paste electrode by electropolymerization via cyclic voltammetry in aqueous media at neutral pH at a single step. The developed biosensors exhibit a linear res...

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Molecules - ISSN 1420-3049