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Molecules, Volume 26, Issue 12

June-2 2021 - 296 articles

Cover Story: In cancer cells, the EphA2 receptor promotes cell migration and increases metastases. These pro-oncogenic signaling events can be reversed by binding the receptor with its dimeric ligands that cause EphA2 degradation. We propose that novel synthetic EphA2 ligands can be engineered by preparing proper biotinylated agonistic peptides, which are then conjugated with streptavidin. We report that the resulting complex presented a markedly increased ability to induce EphA2 receptor degradation in cancer cells. Moreover, we demonstrated that a fluorescently labeled EphA2-targeting–streptavidin complex is localized at the respective tumor sites in orthotopic models of breast and pancreatic cancers, suggesting possible developments of the system for diagnostic or therapeutic applications. View this paper.
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Articles (296)

  • Review
  • Open Access
40 Citations
6,493 Views
27 Pages

21 June 2021

Soap applications for cleaning and personal care have been used for more than 4000 years, dating back to the pharaonic period, and have widely proliferated with the appearance of synthetic surfactants a century ago. Synthetic surfactants used to make...

  • Article
  • Open Access
66 Citations
5,658 Views
27 Pages

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

  • Ayman Abo Elmaaty,
  • Mohammed I. A. Hamed,
  • Muhammad I. Ismail,
  • Eslam B. Elkaeed,
  • Hamada S. Abulkhair,
  • Muhammad Khattab and
  • Ahmed A. Al-Karmalawy

21 June 2021

The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, repurposing of FDA-approved drugs such as NSAIDs against COVID-19 can provide th...

  • Review
  • Open Access
24 Citations
8,424 Views
18 Pages

21 June 2021

In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products conta...

  • Article
  • Open Access
10 Citations
3,418 Views
10 Pages

The Additive Influence of Propane-1,2-Diol on SDS Micellar Structure and Properties

  • Martina Gudelj,
  • Paola Šurina,
  • Lucija Jurko,
  • Ante Prkić and
  • Perica Bošković

21 June 2021

Micellar systems are colloids with significant properties for pharmaceutical and food applications. They can be used to formulate thermodynamically stable mixtures to solubilize hydrophobic food-related substances. Furthermore, micellar formation is...

  • Article
  • Open Access
9 Citations
2,513 Views
14 Pages

21 June 2021

This work addressed the preservative behaviour of different icing media containing extracts from the alga Bifurcaria bifurcata. A comparative study of the antimicrobial and antioxidant effects of aqueous and ethanolic extracts of this macroalga was c...

  • Article
  • Open Access
8 Citations
3,892 Views
15 Pages

Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study

  • Nourhan Hisham Shady,
  • Alaa M. Hayallah,
  • Mamdouh F. A. Mohamed,
  • Mohammed M. Ghoneim,
  • Garri Chilingaryan,
  • Mohammad M. Al-Sanea,
  • Mostafa A. Fouad,
  • Mohamed Salah Kamel and
  • Usama Ramadan Abdelmohsen

21 June 2021

Since December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and serious health problems worldwide. In this study, we investigated 14 natural compounds isolated from Amphimedon sp. via a molecular dockin...

  • Article
  • Open Access
6 Citations
4,128 Views
22 Pages

21 June 2021

Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath samp...

  • Review
  • Open Access
17 Citations
5,835 Views
16 Pages

A Systematic Approach to Agastache mexicana Research: Biology, Agronomy, Phytochemistry, and Bioactivity

  • Mariana Palma-Tenango,
  • Rosa E. Sánchez-Fernández and
  • Marcos Soto-Hernández

20 June 2021

Mexico is the center of origin of the species popularly known as toronjil or lemon balm (Agastache mexicana Linton & Epling). Two subspecies have been identified and are commonly called purple or red (Agastache mexicana Linton & Epling subspe...

  • Article
  • Open Access
55 Citations
8,734 Views
14 Pages

Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones via a Three-Component Biginelli Reaction

  • Giovanna Bosica,
  • Fiona Cachia,
  • Riccardo De Nittis and
  • Nicole Mariotti

20 June 2021

Multicomponent reactions are considered to be of increasing importance as time progresses due to the economic and environmental advantages such strategies entail. The three-component Biginelli reaction involves the combination of an aldehyde, a β-ket...

  • Review
  • Open Access
47 Citations
11,462 Views
32 Pages

Crosslinking Strategies for the Microfluidic Production of Microgels

  • Minjun Chen,
  • Guido Bolognesi and
  • Goran T. Vladisavljević

20 June 2021

This article provides a systematic review of the crosslinking strategies used to produce microgel particles in microfluidic chips. Various ionic crosslinking methods for the gelation of charged polymers are discussed, including external gelation via...

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Molecules - ISSN 1420-3049