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Molecules, Volume 25, Issue 3

February-1 2020 - 334 articles

Cover Story: Oligonucleotides, such as peptide nucleic acid (PNA), designed to block the synthesis of essential bacterial proteins, could be used as antibacterials. The limitation precluding PNA use is that bacterial cells do not uptake PNA. Thus, both PNA carriers and new targets in bacteria have been extensively searched for. The cover presents carriers of PNA to bacteria and possible targets for sequence-specific inhibition by PNA. The delivery strategies comprise covalent conjugation of PNA with cell-penetrating peptides (CPP) and with vitamin B12, as well as complementary base pairing between PNA and DNA to form a tetrahedral DNA nanostructure (TDN). PNA targets tested in Gram-negative bacteria include mRNA, ribosome (small 30S and large 50S subunit), and toxin–antitoxin (TA) systems. View this paper.
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Articles (334)

  • Review
  • Open Access
89 Citations
10,993 Views
14 Pages

9 February 2020

Lonicera caerulea L., also known as haskap or honeysuckle berry, is a fruit commonly planted in eastern Europe, Canada and Asia. The fruit was registered as a traditional food from a third country under European Union regulations only on December 201...

  • Feature Paper
  • Article
  • Open Access
24 Citations
4,470 Views
28 Pages

9 February 2020

The purpose of this study was to evaluate the environmental quality of polluted areas near the Baia Mare Mining and Smelting Complex for future improvements the quality of the environment in polluted areas, such as the city of Baia Mare and its surro...

  • Review
  • Open Access
50 Citations
9,882 Views
21 Pages

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

  • Nicholas G. Economos,
  • Stanley Oyaghire,
  • Elias Quijano,
  • Adele S. Ricciardi,
  • W. Mark Saltzman and
  • Peter M. Glazer

8 February 2020

Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing. By forming high-affinity heterotriplex...

  • Article
  • Open Access
34 Citations
5,007 Views
18 Pages

8 February 2020

Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly applied in biomedicine. They ca...

  • Feature Paper
  • Review
  • Open Access
177 Citations
25,357 Views
20 Pages

Spider Silk for Tissue Engineering Applications

  • Sahar Salehi,
  • Kim Koeck and
  • Thomas Scheibel

8 February 2020

Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture mater...

  • Review
  • Open Access
67 Citations
8,998 Views
16 Pages

Current Approaches to and Future Perspectives on Methomyl Degradation in Contaminated Soil/Water Environments

  • Ziqiu Lin,
  • Wenping Zhang,
  • Shimei Pang,
  • Yaohua Huang,
  • Sandhya Mishra,
  • Pankaj Bhatt and
  • Shaohua Chen

8 February 2020

Methomyl is a broad-spectrum oxime carbamate commonly used to control arthropods, nematodes, flies, and crop pests. However, extensive use of this pesticide in agricultural practices has led to environmental toxicity and human health issues. Oxidatio...

  • Article
  • Open Access
10 Citations
6,367 Views
20 Pages

8 February 2020

Aromatase is an enzyme member of the cytochrome P450 superfamily coded by the CYP19A1 gene. Its main action is the conversion of androgens into estrogens, transforming androstenedione into estrone and testosterone into estradiol. This enzyme is prese...

  • Article
  • Open Access
7 Citations
4,921 Views
15 Pages

Ultrasound and Radiation-Induced Catalytic Oxidation of 1-Phenylethanol to Acetophenone with Iron-Containing Particulate Catalysts

  • Mohamed M. A. Soliman,
  • Maximilian N. Kopylovich,
  • Elisabete C. B. A. Alegria,
  • Ana P. C. Ribeiro,
  • Ana M. Ferraria,
  • Ana M. Botelho do Rego,
  • Luís M. M. Correia,
  • Marta S. Saraiva and
  • Armando J. L. Pombeiro

8 February 2020

Iron-containing particulate catalysts of 0.1–1 µm size were prepared by wet and ball-milling procedures from common salts and characterized by FTIR, TGA, UV-Vis, PXRD, FEG-SEM, and XPS analyses. It was found that when the wet method was u...

  • Article
  • Open Access
17 Citations
6,061 Views
20 Pages

8 February 2020

A series of water-soluble copper(II) complexes based on 2,9-dimethyl-1,10-phenanthroline (dmphen) and mixed-ligands, containing PTA=O (1,3,5-triaza-7-phosphaadamantane-7-oxide) have been synthesized and fully characterized. Two types of complexes hav...

  • Article
  • Open Access
42 Citations
5,985 Views
22 Pages

8 February 2020

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires the...

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Molecules - ISSN 1420-3049