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Open AccessFeature PaperReview

Spider Silk for Tissue Engineering Applications

by Sahar Salehi 1, Kim Koeck 1 and Thomas Scheibel 1,2,3,4,5,*
1
Department for Biomaterials, University of Bayreuth, Prof.-Rüdiger-Bormann-Strasse 1, 95447 Bayreuth, Germany
2
The Bayreuth Center for Colloids and Interfaces (BZKG), University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
3
The Bayreuth Center for Molecular Biosciences (BZMB), University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
4
The Bayreuth Materials Center (BayMAT), University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
5
Bavarian Polymer Institute (BPI), University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(3), 737; https://doi.org/10.3390/molecules25030737
Received: 15 January 2020 / Revised: 2 February 2020 / Accepted: 6 February 2020 / Published: 8 February 2020
(This article belongs to the Special Issue Silk Fibroin Materials)
Due to its properties, such as biodegradability, low density, excellent biocompatibility and unique mechanics, spider silk has been used as a natural biomaterial for a myriad of applications. First clinical applications of spider silk as suture material go back to the 18th century. Nowadays, since natural production using spiders is limited due to problems with farming spiders, recombinant production of spider silk proteins seems to be the best way to produce material in sufficient quantities. The availability of recombinantly produced spider silk proteins, as well as their good processability has opened the path towards modern biomedical applications. Here, we highlight the research on spider silk-based materials in the field of tissue engineering and summarize various two-dimensional (2D) and three-dimensional (3D) scaffolds made of spider silk. Finally, different applications of spider silk-based materials are reviewed in the field of tissue engineering in vitro and in vivo. View Full-Text
Keywords: tissue engineering; biofabrication; hydrogels; coatings; fibers; recombinant spider silk proteins tissue engineering; biofabrication; hydrogels; coatings; fibers; recombinant spider silk proteins
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MDPI and ACS Style

Salehi, S.; Koeck, K.; Scheibel, T. Spider Silk for Tissue Engineering Applications. Molecules 2020, 25, 737.

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