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Molecules, Volume 25, Issue 3

February-1 2020 - 334 articles

Cover Story: Oligonucleotides, such as peptide nucleic acid (PNA), designed to block the synthesis of essential bacterial proteins, could be used as antibacterials. The limitation precluding PNA use is that bacterial cells do not uptake PNA. Thus, both PNA carriers and new targets in bacteria have been extensively searched for. The cover presents carriers of PNA to bacteria and possible targets for sequence-specific inhibition by PNA. The delivery strategies comprise covalent conjugation of PNA with cell-penetrating peptides (CPP) and with vitamin B12, as well as complementary base pairing between PNA and DNA to form a tetrahedral DNA nanostructure (TDN). PNA targets tested in Gram-negative bacteria include mRNA, ribosome (small 30S and large 50S subunit), and toxin–antitoxin (TA) systems. View this paper.
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Articles (334)

  • Review
  • Open Access
264 Citations
24,049 Views
35 Pages

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

  • Camila R. Ferraz,
  • Thacyana T. Carvalho,
  • Marília F. Manchope,
  • Nayara A. Artero,
  • Fernanda S. Rasquel-Oliveira,
  • Victor Fattori,
  • Rubia Casagrande and
  • Waldiceu A. Verri

10 February 2020

Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic bu...

  • Article
  • Open Access
18 Citations
5,196 Views
19 Pages

Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p

  • Camila Hernandes,
  • Lucyene Miguita,
  • Romario Oliveira de Sales,
  • Elisangela de Paula Silva,
  • Pedro Omori Ribeiro de Mendonça,
  • Bruna Lorencini da Silva,
  • Maria de Fatima Guarizo Klingbeil,
  • Monica Beatriz Mathor,
  • Erika Bevilaqua Rangel and
  • Luciana Cavalheiro Marti
  • + 4 authors

10 February 2020

Natural triterpenes exhibit a wide range of biological activities. Since this group of secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions within biological systems. In this work, we investigated t...

  • Article
  • Open Access
24 Citations
5,738 Views
16 Pages

Discrimination of Cultivated Regions of Soybeans (Glycine max) Based on Multivariate Data Analysis of Volatile Metabolite Profiles

  • So-Yeon Kim,
  • So Young Kim,
  • Sang Mi Lee,
  • Do Yup Lee,
  • Byeung Kon Shin,
  • Dong Jin Kang,
  • Hyung-Kyoon Choi and
  • Young-Suk Kim

10 February 2020

Soybean (Glycine max) is a major crop cultivated in various regions and consumed globally. The formation of volatile compounds in soybeans is influenced by the cultivar as well as environmental factors, such as the climate and soil in the cultivation...

  • Article
  • Open Access
25 Citations
5,058 Views
8 Pages

Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance

  • Szilárd Tóth,
  • Áron Szepesi,
  • Viet-Khoa Tran-Nguyen,
  • Balázs Sarkadi,
  • Katalin Német,
  • Pierre Falson,
  • Attilio Di Pietro,
  • Gergely Szakács and
  • Ahcène Boumendjel

10 February 2020

The resistance of tumors against anticancer drugs is a major impediment for chemotherapy. Tumors often develop multidrug resistance as a result of the cellular efflux of chemotherapeutic agents by ABC transporters such as P-glycoprotein (ABCB1/P-gp),...

  • Article
  • Open Access
8 Citations
4,504 Views
13 Pages

9 February 2020

Density, viscosity and surface tension of Kolliphor® ELP, the nonionic surfactant aqueous solutions were measured at temperature T = 293–318 K and at 5K interval. Steady-state fluorescence measurements have been also made using pyrene as a...

  • Article
  • Open Access
40 Citations
4,991 Views
14 Pages

Identification and Characterization of Nematicidal Volatile Organic Compounds from Deep-Sea Virgibacillus dokdonensis MCCC 1A00493

  • Dian Huang,
  • Chen Yu,
  • Zongze Shao,
  • Minmin Cai,
  • Guangyu Li,
  • Longyu Zheng,
  • Ziniu Yu and
  • Jibin Zhang

9 February 2020

Root-knot nematode diseases cause severe yield and economic losses each year in global agricultural production. Virgibacillus dokdonensis MCCC 1A00493, a deep-sea bacterium, shows a significant nematicidal activity against Meloidogyne incognita in vi...

  • Feature Paper
  • Review
  • Open Access
144 Citations
15,734 Views
13 Pages

9 February 2020

During 2019, the US Food and Drug Administration (FDA) approved 48 new drugs (38 New Chemical Entities and 10 Biologics). Although this figure is slightly lower than that registered in 2018 (59 divided between 42 New Chemical Entities and 17 Biologic...

  • Article
  • Open Access
6 Citations
4,439 Views
20 Pages

A Novel Dimeric Exoglucanase (GH5_38): Biochemical and Structural Characterisation towards its Application in Alkyl Cellobioside Synthesis

  • Mpho S. Mafa,
  • Heinrich W. Dirr,
  • Samkelo Malgas,
  • Rui W. M. Krause,
  • Konanani Rashamuse and
  • Brett I. Pletschke

9 February 2020

An exoglucanase (Exg-D) from the glycoside hydrolase family 5 subfamily 38 (GH5_38) was heterologously expressed and structurally and biochemically characterised at a molecular level for its application in alkyl glycoside synthesis. The purified Exg-...

  • Article
  • Open Access
36 Citations
5,555 Views
13 Pages

9 February 2020

A selection of aptamers specific for di(2-ethylhexyl) phthalate (DEHP) and development of electrochemical impedance spectroscopy (EIS) aptasensor are described in this paper. The aptamers were selected from an immobilized ssDNA library using the syst...

  • Review
  • Open Access
65 Citations
9,903 Views
15 Pages

9 February 2020

The development of sustainable processes and products through innovative catalytic materials and procedures that allow a better use of resources is undoubtedly one of the most significant issues facing researchers nowadays. Environmental and economic...

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Molecules - ISSN 1420-3049