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Review

Antibacterial Peptide Nucleic Acids—Facts and Perspectives

1
Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
2
College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland
3
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Eylon Yavin
Molecules 2020, 25(3), 559; https://doi.org/10.3390/molecules25030559
Received: 28 December 2019 / Revised: 20 January 2020 / Accepted: 22 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Peptide Nucleic Acids: Applications in Biomedical Sciences)
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials. The common strategies for antibiotic discovery are based on either modifying existing antibiotics or screening compound libraries, but these strategies have not been successful in recent decades. An alternative approach could be to use gene-specific oligonucleotides, such as peptide nucleic acid (PNA) oligomers, that can specifically target any single pathogen. This approach broadens the range of potential targets to any gene with a known sequence in any bacterium, and could significantly reduce the time required to discover new antimicrobials or their redesign, if resistance arises. We review the potential of PNA as an antibacterial molecule. First, we describe the physicochemical properties of PNA and modifications of the PNA backbone and nucleobases. Second, we review the carriers used to transport PNA to bacterial cells. Furthermore, we discuss the PNA targets in antibacterial studies focusing on antisense PNA targeting bacterial mRNA and rRNA. View Full-Text
Keywords: oligonucleotides; peptide nucleic acid (PNA); antibacterials; RNA; PNA transporters; conjugates; bacterial resistance oligonucleotides; peptide nucleic acid (PNA); antibacterials; RNA; PNA transporters; conjugates; bacterial resistance
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MDPI and ACS Style

Wojciechowska, M.; Równicki, M.; Mieczkowski, A.; Miszkiewicz, J.; Trylska, J. Antibacterial Peptide Nucleic Acids—Facts and Perspectives. Molecules 2020, 25, 559. https://doi.org/10.3390/molecules25030559

AMA Style

Wojciechowska M, Równicki M, Mieczkowski A, Miszkiewicz J, Trylska J. Antibacterial Peptide Nucleic Acids—Facts and Perspectives. Molecules. 2020; 25(3):559. https://doi.org/10.3390/molecules25030559

Chicago/Turabian Style

Wojciechowska, Monika, Marcin Równicki, Adam Mieczkowski, Joanna Miszkiewicz, and Joanna Trylska. 2020. "Antibacterial Peptide Nucleic Acids—Facts and Perspectives" Molecules 25, no. 3: 559. https://doi.org/10.3390/molecules25030559

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