- Article
Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin
- Shigeru Shimamoto,
- Mayu Fukutsuji,
- Toi Osumi,
- Masaya Goto,
- Hiroshi Toyoda and
- Yuji Hidaka
Heat-stable enterotoxin (STa) produced by enterotoxigenic E. coli causes acute diarrhea and also can be used as a specific probe for colorectal cancer cells. STa contains three intra-molecular disulfide bonds (C1–C4, C2–C5, and C3–C...

