Table of Contents
Molecules, Volume 25, Issue 20 (October-2 2020) – 277 articles
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Cover Story (view full-size image) Mitotic poisons have dominated anticancer therapy for decades. Suppressing cancer cell division is [...] Read more. Mitotic poisons have dominated anticancer therapy for decades. Suppressing cancer cell division is a time-tested approach, mainly targeting microtubules, kinases, and kinesins involved in mitosis. To date, hundreds of natural product inhibitors binding to such proteins have been identified, dozens of which have been approved clinically. Why are these compounds still so popular and will it remain like that? What are their major advantages or disadvantages? Which options do we have to improve their clinical potential and what are the major directions of the antimitotic research to date? Responses to these and many other questions concerning antimitotic drugs are offered within this up-to-date review article focused on mitotic poisons in research and medicine. View this paper.