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Molecules, Volume 25, Issue 20

October-2 2020 - 277 articles

Cover Story: Mitotic poisons have dominated anticancer therapy for decades. Suppressing cancer cell division is a time-tested approach, mainly targeting microtubules, kinases, and kinesins involved in mitosis. To date, hundreds of natural product inhibitors binding to such proteins have been identified, dozens of which have been approved clinically. Why are these compounds still so popular and will it remain like that? What are their major advantages or disadvantages? Which options do we have to improve their clinical potential and what are the major directions of the antimitotic research to date? Responses to these and many other questions concerning antimitotic drugs are offered within this up-to-date review article focused on mitotic poisons in research and medicine. View this paper.
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Articles (277)

  • Article
  • Open Access
10 Citations
3,278 Views
11 Pages

Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin

  • Shigeru Shimamoto,
  • Mayu Fukutsuji,
  • Toi Osumi,
  • Masaya Goto,
  • Hiroshi Toyoda and
  • Yuji Hidaka

21 October 2020

Heat-stable enterotoxin (STa) produced by enterotoxigenic E. coli causes acute diarrhea and also can be used as a specific probe for colorectal cancer cells. STa contains three intra-molecular disulfide bonds (C1–C4, C2–C5, and C3–C...

  • Review
  • Open Access
31 Citations
5,963 Views
16 Pages

The Circular Life of Human CD38: From Basic Science to Clinics and Back

  • Alberto L. Horenstein,
  • Angelo C. Faini,
  • Fabio Morandi,
  • Cristiano Bracci,
  • Francesco Lanza,
  • Nicola Giuliani,
  • Aneel Paulus and
  • Fabio Malavasi

21 October 2020

Monoclonal antibodies (mAbs) were initially considered as a possible “magic bullet” for in vivo elimination of tumor cells. mAbs represented the first step: however, as they were murine in nature (the earliest experience on the field), th...

  • Article
  • Open Access
9 Citations
3,096 Views
14 Pages

21 October 2020

Hypoxia is a common pathological process in various clinical diseases. However, there is still a lack of effective anti-hypoxia active substances. Agaricus bitorguis (Quél.) Sacc Chaidam (ABSC) is a rare wild edible macrofungus that grows unde...

  • Article
  • Open Access
20 Citations
3,487 Views
17 Pages

Micro-Fibrillated Cellulose in Adhesive Systems for the Production of Wood-Based Panels

  • Emmanouil Karagiannidis,
  • Charles Markessini and
  • Eleftheria Athanassiadou

21 October 2020

Micro-Fibrillated Cellulose (MFC) is a new type of bio-based additive, coming from wood cellulose. It can compete and substitute oil derived chemicals in several application fields. In the present work, the use of micro-fibrillated cellulose, in wate...

  • Article
  • Open Access
4 Citations
3,151 Views
18 Pages

Structural Evolution and Magnetic Properties of Gd2Hf2O7 Nanocrystals: Computational and Experimental Investigations

  • Madhab Pokhrel,
  • Nicholas Dimakis,
  • Chamath Dannangoda,
  • Santosh K. Gupta,
  • Karen S. Martirosyan and
  • Yuanbing Mao

21 October 2020

Structural evolution in functional materials is a physicochemical phenomenon, which is important from a fundamental study point of view and for its applications in magnetism, catalysis, and nuclear waste immobilization. In this study, we used x-ray d...

  • Article
  • Open Access
5 Citations
4,092 Views
10 Pages

Total Synthesis of Phorbazole B

  • Yngve Guttormsen,
  • Magnus E. Fairhurst,
  • Sunil K. Pandey,
  • Johan Isaksson,
  • Bengt Erik Haug and
  • Annette Bayer

21 October 2020

Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B u...

  • Article
  • Open Access
11 Citations
6,582 Views
18 Pages

Tri-Herbal Medicine Divya Sarva-Kalp-Kwath (Livogrit) Regulates Fatty Acid-Induced Steatosis in Human HepG2 Cells through Inhibition of Intracellular Triglycerides and Extracellular Glycerol Levels

  • Acharya Balkrishna,
  • Vivek Gohel,
  • Rani Singh,
  • Monali Joshi,
  • Yash Varshney,
  • Jyotish Srivastava,
  • Kunal Bhattacharya and
  • Anurag Varshney

21 October 2020

Steatosis is characterized by excessive triglycerides accumulation in liver cells. Recently, application of herbal formulations has gained importance in treating complex diseases. Therefore, this study explores the efficacy of tri-herbal medicine Div...

  • Article
  • Open Access
11 Citations
3,556 Views
18 Pages

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

  • Tal Tilayov,
  • Tal Hingaly,
  • Yariv Greenshpan,
  • Shira Cohen,
  • Barak Akabayov,
  • Roi Gazit and
  • Niv Papo

21 October 2020

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cell...

  • Article
  • Open Access
3 Citations
3,707 Views
18 Pages

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation

  • Laurita Boff,
  • André Schreiber,
  • Aline da Rocha Matos,
  • Juliana Del Sarto,
  • Linda Brunotte,
  • Jennifer Munkert,
  • Flaviano Melo Ottoni,
  • Gabriela Silva Ramos,
  • Wolfgang Kreis and
  • Fernão Castro Braga
  • + 4 authors

21 October 2020

Influenza virus infections represent a major public health issue by causing annual epidemics and occasional pandemics that affect thousands of people worldwide. Vaccination is the main prophylaxis to prevent these epidemics/pandemics, although the ef...

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Molecules - ISSN 1420-3049Creative Common CC BY license