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Special Issue "Frontiers in RNA Structure"
Deadline for manuscript submissions: 15 February 2020.
Interests: biochemistry; cryo-electron microscopy; molecular biology; ribosome; RNA structure and folding; structure prediction; X-ray crystallography
Ribonucleic acids (RNA) can code for information, act as enzymes or change shape upon binding to an effector. Significantly, the dynamic nature of RNA means that RNA is able to adopt transient structures with diverse functions. In addition, the fraction of noncoding RNA in our genomes is much larger than that of messenger RNA. Hence, RNA has now emerged as one of the key molecules in the regulation of gene expression. However, our understanding of the functions and structures of these myriad RNAs pales in comparison to what we know about proteins.
The focus of this Special Issue is on the frontier of RNA structure discovery and the structure–function relationship. We welcome submissions about any type of RNA or ribonucleoprotein complex, and any structural biology methodology, including but not limited to: X-ray/electron crystallography, NMR, cryo-electron microscopy, small-angle X-ray scattering, FRET, structure mapping, and computational modeling.
Articles reporting original research as well as reviews will be considered for publication.
Authors are strongly encouraged to submit a brief abstract (200 words) to the guest editor by October 15, 2019. Abstracts will be reviewed in consultation with the editors at Molecules. Full manuscripts submitted by February 15, 2020 will be guaranteed full consideration.
Dr. Quentin Vicens
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- coding and noncoding RNA
- regulatory RNA
- RNA dynamics
- RNA–protein complex
- structured RNA element
- three-dimensional structure
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The multiple scales of ribosome heterogeneity: recent advances and computational challenges in cryoEM
Authors: Frederic Poitevin 1 and Khanh Dao Duc 2
Affiliations: 1 Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA;2 Departments of Mathematics, Computer Science, and Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Email: [email protected]
Abstract: The extent of ribosomal heterogeneity has caught increasing interest over the past few years, as recent studies have highlighted the presence of structural variations of the ribosome, yielding specialized gene expression at the cellular and sub-cellular scale. As a matter of fact, the heterogeneity of the ribosome extends well beyond these scales, including the dynamical aspects of ribosomal motion at the single particle level, or evolutionary differences across species. Investigating these other forms of ribosome heterogeneity has been enabled by the renement and wide use of cryo-electron microscopy (cryo-EM), giving access to the ribosome atomic structure at high resolution. In this review article, we present some recent advances in quantifying ribosome heterogeneity, with a specic focus on conformational and evolutionary variations of the ribosome, with their functional implications. Interestingly, these recent eorts also highlight the need for new computational methods and comparative tools, to comprehensively model the continuous conformational transition pathways of the ribosome, as well as its evolution. While developing these methods presents some important challenges, it also provides an opportunity to extend our interpretation and usage of cryo-EM data which, more generally, would benet to studying in detail the molecular dynamics and evolution of proteins and other complexes.