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Special Issue "Synthesis and Evaluation of Antioxidant and Antiproliferative Activity of Plant Natural Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editors

Prof. Dr. Stefano Manfredini
Guest Editor
Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy
Interests: synthesis; isolation; natural compounds; UV protection; cosmetics
Special Issues and Collections in MDPI journals
Dr. Rino Ragno
Guest Editor
Sapienza University Rome Ctr Mol Design, Ple Aldo Moro 5, I-00185 Rome, Italy

Special Issue Information

Dear Colleagues,

It is well known that the major source of inspiration in the design of small active compounds is still nature, with its biodiversity, which still creates successful solutions elaborated during millions of years of evolution. On the other side, antioxidants are the principal secondary metabolism products in plants, and it is only in view of their presence that some marine organisms escape by water, because they are protected against the toxic and mutagenic effects of environmental UV radiations. One of the principal effects of UV radiation is the generation of ROS and the consequently related tumor-promoting effects. Thus, antioxidant and antitumor effects are deeply connected not only through prevention but also through counteraction toward oxidative status generated by neoplastic tissues.

Both due to popular tradition and also due to the renewed interest toward the discovery of structurally novel bioactive compounds from natural sources, synthetic modification is often necessary to improve the biological profile and understand structure–activity relationships, to enlarge basic investigations to support novel candidates for the development of the pharmaceutical industry. This Special Issue is focused on both original research and review articles that cover the synthesis and evaluation of bioactive compounds from plants. Their structure–activity relationship and molecular mechanisms of action are also an important topic of this Special Issue.

Prof. Stefano Manfredini
Dr. Rino Ragno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • synthesis
  • evaluation
  • antiproliferative
  • natural compound
  • antioxidants

Published Papers

This special issue is now open for submission.
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