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Special Issue "Synthesis and Evaluation of Antioxidant and Antiproliferative Activity of Plant Natural Compounds"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2020).

Special Issue Editors

Prof. Dr. Stefano Manfredini
E-Mail Website
Guest Editor
Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy
Interests: synthesis; isolation; natural compounds; UV protection; cosmetics
Special Issues and Collections in MDPI journals
Dr. Rino Ragno
E-Mail Website
Guest Editor
Sapienza University Rome Ctr Mol Design, Ple Aldo Moro 5, I-00185 Rome, Italy

Special Issue Information

Dear Colleagues,

It is well known that the major source of inspiration in the design of small active compounds is still nature, with its biodiversity, which still creates successful solutions elaborated during millions of years of evolution. On the other side, antioxidants are the principal secondary metabolism products in plants, and it is only in view of their presence that some marine organisms escape by water, because they are protected against the toxic and mutagenic effects of environmental UV radiations. One of the principal effects of UV radiation is the generation of ROS and the consequently related tumor-promoting effects. Thus, antioxidant and antitumor effects are deeply connected not only through prevention but also through counteraction toward oxidative status generated by neoplastic tissues.

Both due to popular tradition and also due to the renewed interest toward the discovery of structurally novel bioactive compounds from natural sources, synthetic modification is often necessary to improve the biological profile and understand structure–activity relationships, to enlarge basic investigations to support novel candidates for the development of the pharmaceutical industry. This Special Issue is focused on both original research and review articles that cover the synthesis and evaluation of bioactive compounds from plants. Their structure–activity relationship and molecular mechanisms of action are also an important topic of this Special Issue.

Prof. Stefano Manfredini
Dr. Rino Ragno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis
  • evaluation
  • antiproliferative
  • natural compound
  • antioxidants

Published Papers (2 papers)

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Research

Article
Phytochemicals and Antioxidant Activity in Oat-Buckwheat Dough and Cookies with Added Spices or Herbs
Molecules 2021, 26(8), 2267; https://doi.org/10.3390/molecules26082267 - 14 Apr 2021
Viewed by 556
Abstract
The aim of this study was to determine the phytochemicals and antioxidant activity in oat-buckwheat doughs and cookies with the addition of ten selected spices or herbs (2 g/100 g flours weight basis). The used spices and herbs, as was expected, showed a [...] Read more.
The aim of this study was to determine the phytochemicals and antioxidant activity in oat-buckwheat doughs and cookies with the addition of ten selected spices or herbs (2 g/100 g flours weight basis). The used spices and herbs, as was expected, showed a wide range of bioactive molecules, namely phenolic acids and flavonoids, and they are a rich source of components with antioxidant potential. All analysed oat-buckwheat dough showed higher antioxidant activity potential and higher total phenolic content (TPC) compared to cookies. The highest TPC was found in clove, both dough and cookies, with its addition showing the highest ferric reducing antioxidant power. Generally, cookies with the addition of spice/herbs showed higher phytochemical contents and antioxidant activity compared to oat-buckwheat cookies without the condiment. The technology of obtaining confectionery products, like oat-buckwheat cookies, that will favor the protection of bioactive compounds should still be improved. Full article
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Article
Phenolic Acids-Rich Fractions from Agaricus bitorguis (Quél.) Sacc. Chaidam ZJU-CDMA-12 Mycelia Modulate Hypoxic Stress on Hypoxia-Damaged PC12 Cells
Molecules 2020, 25(20), 4845; https://doi.org/10.3390/molecules25204845 - 21 Oct 2020
Viewed by 585
Abstract
Hypoxia is a common pathological process in various clinical diseases. However, there is still a lack of effective anti-hypoxia active substances. Agaricus bitorguis (Quél.) Sacc Chaidam (ABSC) is a rare wild edible macrofungus that grows underground at high altitudes. Herein, intracellular phenolic acids-rich [...] Read more.
Hypoxia is a common pathological process in various clinical diseases. However, there is still a lack of effective anti-hypoxia active substances. Agaricus bitorguis (Quél.) Sacc Chaidam (ABSC) is a rare wild edible macrofungus that grows underground at high altitudes. Herein, intracellular phenolic acids-rich fractions (IPA) were extracted from ABSC ZJU-CDMA-12, and the structural characterization and anti-hypoxia activity of IPA on PC12 cells were elucidated as well. The results of HPLC-Q-TOF-MS illustrated that five kinds of IPA were isolated from ABSC, including (−)-epicatechin gallate, arabelline, yunnaneic acid D, 2′-O-p-hydroxybenzoyl-6′-O-trans-caffeoylgardoside,4′-O-methylgallocatechin-(4->8)-4′-O-methylepigallocatechin. IPA extracted from ABSC proved to show anti-hypoxia activity on hypoxia-damaged PC12 cells. Hypoxia enhanced reactive oxygen species (ROS) generation and reduced the mitochondrial membrane potential (ΔΨm) in PC12 cells, resulting in the inhibition of survival and induction of apoptosis in PC12 cells. Measurements of 100 μg/mL and 250 μg/mL IPA could significantly reduce hypoxia-induced damage in PC12 cells by decreasing overproduced intracellular ROS, improving ΔΨm, and reducing cell apoptosis rate. Our findings indicated that the IPA from ABSC potentially could be used as novel bioactive components applied to anti-hypoxia functional foods or medicines. Full article
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