Table of Contents
Molecules, Volume 24, Issue 10 (May-2 2019)
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Cover Story (view full-size image) Harnessing the rapid-onset yet sustained antidepressant effects of ketamine metabolites requires [...] Read more. Harnessing the rapid-onset yet sustained antidepressant effects of ketamine metabolites requires chiral quantification methods. Enantioseparation of S-/R-ketamine, S-/R-norketamine, S-/R-dehydronorketamine, and (2R,6R)-/(2S,6S)-hydroxynorketamine is known to benefit from the use of supercritical fluids such as pressurized and heated CO2—but is higher really better in terms of temperature? Here, subcritical fluid chromatography (SubFC) at subambient temperatures demonstrated superior separation when compared to supercritical fluid (SFC), liquid (HPLC), and extended-fluidity liquid chromatography (EFLC) as applied to the same chiral polysaccharide-based stationary phases. Combined with online supercritical fluid extraction, the chiral quality of promising ketamine formulations can be assessed with minimal sample preparation. View this paper.