Special Issue "Gelatin: Chemistry, Characterization, Application"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 30 November 2018
Dr. Silvia Panzavolta
This Special Issue is related to the chemistry, characterization and application of gelatin. Gelatin, obtained by chemical-thermal degradation of collagen, is one of the most employed biopolymers, thanks to its biodegradability, excellent biocompatibility, plasticity, adhesiveness, abundance, and low cost. The main drawbacks of gelatin as a material are its poor mechanical performance and its high solubility in aqueous environments, which can be improved through crosslinking or by combining the biopolymer with an inorganic filler. Gelatin-based materials could be developed and applied in multidisciplinary fields, for example packaging, food, pharmaceutical industry, cosmetic industry, as well as for the production of materials addressed to biomedical field.
All researchers working in the field are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules, which focuses on gelatin new crosslinking methods, on the design and synthesis of gelatin-based biomaterials and scaffolds for osteochondral defect repair, on the performance of gelatin as tailored drug delivery systems, on the evaluation of novel gelatin-based materials for cosmetic and packaging applications, as well as on the characterization of chemical-physical properties with advanced analyses.
Dr. Silvia Panzavolta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Gelatin crosslinking
- Gelatin-based biomaterials
- Gelatin as delivery system of bioactive molecules
- Gelatin films and patches
- Gelatin characterization
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Methacrylic modified gelatin hydrogels as a new suitable material for astrocyte 3D culture scaffold
Authors: Federico Cantoni, Ana Maria Porras, Hannah Pohlit, Ayan Samanta, Jöns Hilborn and Maria Tenje
Affiliations: Dep. Engineering Sciences and Polymer Chemistry, Uppsala University, Uppsala, Sweden
Abstract: The implementation of polymeric hydrogels as biocompatible scaffolds for cell culture has resulted in great advances in tissue engineering in the last decades. Among the wide variety of hydrogel precursor polymers, methacrylic modified gelatin (GelMA) has been one of the most employed and studied for cell culture due to its tuneable physical properties, good biocompatibility and low cost. Among the significant amount of the publications reporting on GelMA as a cell culture scaffold, no study has yet reported on the culture of astrocytes on this polymer. For this reason, in view of the growing interest in the development of new in-vitro nervous system models, this work reports on the feasibility of the astrocyte 3D culture in GelMA. The research investigates the influence of the hydrogel mechanical properties, which can be tuned by varying the GelMA polymer concentration, over the cell adhesion, spreading and proliferation on the scaffold surface. Further, these results are combined with the live-dead assessment to identify hydrogel precursor concentration, which shows the optimal conditions for the cell growth. In conclusion, the study demonstrates the capability of GelMA to provide a valid option for the astrocyte culture and future biological investigations on this type of cells.