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Molecules 2017, 22(2), 193;

Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers

School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Guangxi, China
Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530008, Guangxi, China
Author to whom correspondence should be addressed.
Academic Editor: Panayiotis A. Koutentis
Received: 24 December 2016 / Revised: 21 January 2017 / Accepted: 21 January 2017 / Published: 24 January 2017
(This article belongs to the Section Medicinal Chemistry)
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A series of novel myrtenal derivatives bearing 1,2,4-triazole moiety were designed and synthesized by multi-step reactions in an attempt to develop potent antifungal agents. Their structures were confirmed by using UV-vis, FTIR, NMR, and ESI-MS analysis. Antifungal activity of the target compounds was preliminarily evaluated by the in vitro method against Fusarium oxysporum f. sp. cucumerinum, Physalospora piricola, Alternaria solani, Cercospora arachidicola, and Gibberella zeae at 50 µg/mL. Compounds 6c (R = i-Pr), 6l (R = o-NO2 Bn), and 6a (R = Et) exhibited excellent antifungal activity against P. piricola with inhibition rates of 98.2%, 96.4%, and 90.7%, respectively, showing better or comparable antifungal activity than that of the commercial fungicide azoxystrobin with a 96.0% inhibition rate, which served as a positive control. View Full-Text
Keywords: α-pinene; myrtenal; 1,2,4-triazole-thioether; antifungal activity α-pinene; myrtenal; 1,2,4-triazole-thioether; antifungal activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lin, G.-S.; Duan, W.-G.; Yang, L.-X.; Huang, M.; Lei, F.-H. Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers. Molecules 2017, 22, 193.

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